Table 3.
Locus | SNP (Minor Allele) | Case-Control Study | Case-Only Study | ||||||
MAFcase/control | OR (95% CI)* | P* | MAFagg/nonagg | OR (95% CI)* | P* | ||||
REDUCE (N = 410/1234) | CAPS (N = 2899/1722) | REDUCE (N = 124/281) | CAPS (N = 1231/1619) | ||||||
ATF7IP | rs3213764 (G) | 0.445/0.465 | 0.519/0.499 | 1.05 (0.97–1.13) | 0.214 | 0.456/0.441 | 0.524/0.517 | 1.02 (0.92.1.13) | 0.737 |
KLK2 | rs1354774 (G) | 0.345/0.341 | 0.340/0.335 | 1.01 (0.94–1.10) | 0.722 | 0.367/0.336 | 0.332/0.344 | 0.98 (0.88.1.09) | 0.716 |
Odds ratios (ORs), 95% confidence intervals (CIs), and P values were estimated using inverse variance-weighted meta-analyses according to regression coefficients and corresponding SEs across REDUCE and CAPS studies.