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. 1971 Jan;7(1):8–14. doi: 10.1128/jvi.7.1.8-14.1971

Inhibition of T4 Bacteriophage Multiplication by Superinfecting Ghosts and the Development of Tolerance After Bacteriophage Infection

Donna Hardy Duckworth 1
PMCID: PMC356071  PMID: 5543436

Abstract

Simultaneous addition of T4 phage and ghosts to host cells prevents infective center formation. Cells which have been infected with phage for less than 2 min are also inhibited by superinfecting ghosts. After this time, a chloramphenicol-inhibitable reaction occurs which causes the phage-infected cells to become increasingly tolerant of added ghosts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BONIFAS V., KELLENBERGER E. Etude de l'action des membranes du bactériophage T2 sur Escherichia coli. Biochim Biophys Acta. 1955 Mar;16(3):330–338. doi: 10.1016/0006-3002(55)90234-1. [DOI] [PubMed] [Google Scholar]
  2. DULBECCO R. Mutual exclusion between related phages. J Bacteriol. 1952 Feb;63(2):209–217. doi: 10.1128/jb.63.2.209-217.1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Doermann A. H. Lysis and Lysis Inhibition with Escherichia coli Bacteriophage. J Bacteriol. 1948 Feb;55(2):257–276. doi: 10.1128/jb.55.2.257-276.1948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Duckworth D. H., Bessman M. J. Assay for the Killing Properties of T2 Bacteriophage and Their "Ghosts". J Bacteriol. 1965 Sep;90(3):724–728. doi: 10.1128/jb.90.3.724-728.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Duckworth D. H. Biological activity of bacteriophage ghosts and "take-over" of host functions by bacteriophage. Bacteriol Rev. 1970 Sep;34(3):344–363. doi: 10.1128/br.34.3.344-363.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Duckworth D. H. The metabolism of T4 phage ghost-infected cells. I. Macromolecular synthesis and ransport of nucleic acid and protein precursors. Virology. 1970 Mar;40(3):673–684. doi: 10.1016/0042-6822(70)90212-6. [DOI] [PubMed] [Google Scholar]
  7. FRENCH R. C., SIMINOVITCH L. The action of T2 bacteriophage ghosts on Escherichia coli B. Can J Microbiol. 1955 Dec;1(9):757–774. doi: 10.1139/m55-090. [DOI] [PubMed] [Google Scholar]
  8. FUKASAWA T. THE COURSE OF INFECTION WITH ABNORMAL BACTERIOPHAGE T4 CONTAINING NON-GLUCOSYLATED DNA ON ESCHERICHIA COLI STRAINS. J Mol Biol. 1964 Aug;9:525–536. doi: 10.1016/s0022-2836(64)80224-2. [DOI] [PubMed] [Google Scholar]
  9. Furrow M. H., Pizer L. I. Phospholipid synthesis in Escherichia coli infected with T4 bacteriophages. J Virol. 1968 Jun;2(6):594–605. doi: 10.1128/jvi.2.6.594-605.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GORINI L., KAUFMAN H. Selecting bacterial mutants by the penicillin method. Science. 1960 Feb 26;131(3400):604–605. doi: 10.1126/science.131.3400.604. [DOI] [PubMed] [Google Scholar]
  11. HERRIOTT R. M., BARLOW J. L. The protein coats or ghosts of coli phage T2. II. The biological functions. J Gen Physiol. 1957 Nov 20;41(2):307–331. doi: 10.1085/jgp.41.2.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HERZENBERG L. A. Studies on the induction of beta-galactosidase in a cryptic strain of Escherichia coli. Biochim Biophys Acta. 1959 Feb;31(2):525–538. doi: 10.1016/0006-3002(59)90029-0. [DOI] [PubMed] [Google Scholar]
  13. Israeli M., Artman M. Leakage of beta-galactosidase from phage-infected Escherichia coli: a re-evaluation. J Gen Virol. 1970;7(2):137–142. doi: 10.1099/0022-1317-7-2-137. [DOI] [PubMed] [Google Scholar]
  14. KOCH A. L. THE ROLE OF PERMEASE IN TRANSPORT. Biochim Biophys Acta. 1964 Jan 27;79:177–200. doi: 10.1016/0926-6577(64)90050-6. [DOI] [PubMed] [Google Scholar]
  15. Krylov V. N. Possible function of rII genes of bacteriophage T4. Virology. 1970 Aug;41(4):711–717. doi: 10.1016/0042-6822(70)90435-6. [DOI] [PubMed] [Google Scholar]
  16. Lembach K. J., Buchanan J. M. The relationship of protein synthesis to early transcriptive events in bacteriophage T4-infected Escherichia coli B. J Biol Chem. 1970 Apr 10;245(7):1575–1587. [PubMed] [Google Scholar]
  17. Mukai F., Streisinger G., Miller B. The mechanism of lysis in phage T4-infected cells. Virology. 1967 Nov;33(3):398–404. doi: 10.1016/0042-6822(67)90115-8. [DOI] [PubMed] [Google Scholar]
  18. Nagel de Zwaig R., Luria S. E. Genetics and physiology of colicin-tolerant mutants of Escherichia coli. J Bacteriol. 1967 Oct;94(4):1112–1123. doi: 10.1128/jb.94.4.1112-1123.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Nomura M., Witten C. Interaction of colicins with bacterial cells. 3. Colicin-tolerant mutations in Escherichia coli. J Bacteriol. 1967 Oct;94(4):1093–1111. doi: 10.1128/jb.94.4.1093-1111.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Nomura M., Witten C., Mantei N., Echols H. Inhibition of host nucleic acid synthesis by bacteriophage T4: effect of chloramphenicol at various multiplicities of infection. J Mol Biol. 1966 May;17(1):273–278. doi: 10.1016/s0022-2836(66)80107-9. [DOI] [PubMed] [Google Scholar]
  21. PUCK T. T., LEE H. H. Mechanism of cell wall penetration by viruses. I. An increase in host cell permeability induced by bacteriophage infection. J Exp Med. 1954 May 1;99(5):481–494. doi: 10.1084/jem.99.5.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. PUCK T. T., LEE H. H. Mechanism of cell wall penetration by viruses. II. Demonstration of cyclic permeability change accompanying virus infection of Escherichia coli B cells. J Exp Med. 1955 Feb 1;101(2):151–175. doi: 10.1084/jem.101.2.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Silver S. Acridine sensitivity of bacteriophage T2: a virus gene affecting cell permeability. J Mol Biol. 1967 Oct 14;29(1):191–202. doi: 10.1016/0022-2836(67)90190-8. [DOI] [PubMed] [Google Scholar]
  24. Silver S., Levine E., Spielman P. M. Cation fluxes and permeability changes accompanying bacteriophage infection of Escherichia coli. J Virol. 1968 Aug;2(8):763–771. doi: 10.1128/jvi.2.8.763-771.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Winkler H. H., Wilson T. H. The role of energy coupling in the transport of beta-galactosides by Escherichia coli. J Biol Chem. 1966 May 25;241(10):2200–2211. [PubMed] [Google Scholar]

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