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. 1971 Feb;7(2):221–226. doi: 10.1128/jvi.7.2.221-226.1971

Deoxyribonucleic Acid Polymerase Activity Associated with a Plasma Particulate Fraction from Patients with Chronic Lymphocytic Leukemia 1

A A Kiessling a, G H Weber a, A O Deeney a, E A Possehl a, G S Beaudreau a
PMCID: PMC356102  PMID: 4999944

Abstract

Plasma from two cases of chronic lymphocytic leukemia have been examined for deoxyribonucleic acid (DNA) polymerase activity. In both cases, detectable enzyme activity was present. In the plasma from a patient known to have chronic lymphocytic leukemia for 10 years, the enzyme activity was sufficiently high to study product formation, buoyant density of the enzyme activity, deoxyribonucleoside triphosphate requirements, and kinetics of DNA synthesis. These studies are presented in this report.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bader J. P., Brown N. R., Bader A. V. Characteristics of cores of avian leuko-sarcoma viruses. Virology. 1970 Aug;41(4):718–728. doi: 10.1016/0042-6822(70)90436-8. [DOI] [PubMed] [Google Scholar]
  2. Baltimore D. RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature. 1970 Jun 27;226(5252):1209–1211. doi: 10.1038/2261209a0. [DOI] [PubMed] [Google Scholar]
  3. Gerwin B. I., Todaro G. J., Zeve V., Scolnick E. M., Aaronson S. A. Separation of RNA-dependent DNA polymerase activity from the murine leukaemia virion. Nature. 1970 Oct 31;228(5270):435–438. doi: 10.1038/228435a0. [DOI] [PubMed] [Google Scholar]
  4. Green M., Rokutanda M., Fujinaga K., Ray R. K., Rokutanda H., Gurgo C. Mechanism of carcinogenesis by RNA tumor viruses. I. An RNA-dependent DNA polymerase in murine sarcoma viruses. Proc Natl Acad Sci U S A. 1970 Sep;67(1):385–393. doi: 10.1073/pnas.67.1.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hatanaka M., Huebner R. J., Gilden R. V. DNA polymerase activity associated with RNA tumor viruses. Proc Natl Acad Sci U S A. 1970 Sep;67(1):143–147. doi: 10.1073/pnas.67.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. McDonnell J. P., Garapin A. C., Levinson W. E., Quintrell N., Fanshier L., Bishop J. M. DNA polymerases of Rous sarcoma virus: delineation of two reactions with actinomycin. Nature. 1970 Oct 31;228(5270):433–435. doi: 10.1038/228433a0. [DOI] [PubMed] [Google Scholar]
  7. Ríman J., Beaudreau G. S. Viral DNA-dependent DNA polymerase and the properties of thymidine labelled material in virions of an oncogenic RNA virus. Nature. 1970 Oct 31;228(5270):427–430. doi: 10.1038/228427a0. [DOI] [PubMed] [Google Scholar]
  8. Scolnick E. M., Aaronson S. A., Todaro G. J. DNA synthesis by RNA-containing tumor viruses. Proc Natl Acad Sci U S A. 1970 Oct;67(2):1034–1041. doi: 10.1073/pnas.67.2.1034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Spiegelman S., Burny A., Das M. R., Keydar J., Schlom J., Travnicek M., Watson K. Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses. Nature. 1970 Aug 8;227(5258):563–567. doi: 10.1038/227563a0. [DOI] [PubMed] [Google Scholar]
  10. Temin H. M., Mizutani S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature. 1970 Jun 27;226(5252):1211–1213. doi: 10.1038/2261211a0. [DOI] [PubMed] [Google Scholar]
  11. Weber G. H., Kiessling A. A., Beaudreau G. S. Deoxyribonucleic acid polymerase activity associated with strain MC29 tumor virus. J Virol. 1971 Feb;7(2):214–220. doi: 10.1128/jvi.7.2.214-220.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

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