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. 1971 Feb;7(2):227–232. doi: 10.1128/jvi.7.2.227-232.1971

Deoxyribonucleic Acid Polymerases of Rous Sarcoma Virus: Kinetics of Deoxyribonucleic Acid Synthesis and Specificity of the Products

Axel-Claude Garapin a,1, Lois Fanshier a, Jo-Ann Leong a, Jean Jackson a, Warren Levinson a, J Michael Bishop a
PMCID: PMC356103  PMID: 4329398

Abstract

The deoxyribonucleic acid (DNA) polymerase(s) of Rous sarcoma virus synthesizes two principal products—single-stranded DNA in the form of a DNA:ribonucleic acid (RNA) hybrid and double-stranded DNA. All of the single-stranded product and 50% of the double-stranded product can be hybridized to 70S viral RNA. These results, in combination with data obtained by analysis of the kinetics of double-stranded DNA synthesis, indicate that the synthesis of double-stranded DNA is a sequel to the synthesis of single-stranded DNA and is dependent upon the latter for the provision of initial template.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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