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Journal of Virology logoLink to Journal of Virology
. 1971 Mar;7(3):389–394. doi: 10.1128/jvi.7.3.389-394.1971

Ribonucleic Acud Polymerase in Virions of Newcastle Disease Virus: Comparison with the Vesicular Stomatitis Virus Polymerase

Alice S Huang 1,2,1, David Baltimore 1,2, Michael A Bratt 1,2
PMCID: PMC356129  PMID: 4323712

Abstract

The virions of Newcastle disease virus (NDV) contained an enzyme that catalyzed the incorporation of ribonucleotides into ribonucleic acid (RNA). Optimal conditions for this polymerase activity were identical to the conditions for the vesicular stomatitis virus (VSV) polymerase, and both enzymes were active for longer times at 32 C than at 37 C. However, the specific activity of the NDV polymerase was less than 3% that of the VSV polymerase. Product RNA species from the NDV and VSV polymerase reactions annealed specifically to the homologous virion RNA species. Transcriptive intermediates containing product RNA attached to the respective virion RNA could be identified in both systems.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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