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. 1971 Mar;7(3):409–411. doi: 10.1128/jvi.7.3.409-411.1971

Absence of Interference During High-Multiplicity Infection by Clonally Purified Vesicular Stomatitis Virus

Martha Stampfer a, David Baltimore a, Alice S Huang a,1
PMCID: PMC356132  PMID: 4323713

Abstract

Stocks of vesicular stomatitis virus free of defective interfering particles were produced by serial clonal isolation. High-multiplicity infections with these stocks led to no interference or formation of defective interfering particles. Defective interfering particles were generated by three successive passages at high multiplicity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BELLETT A. J., COOPER P. D. Some properties of the transmissible interfering component of vesicular stomatitis virus preparations. J Gen Microbiol. 1959 Dec;21:498–509. doi: 10.1099/00221287-21-3-498. [DOI] [PubMed] [Google Scholar]
  2. Choppin P. W. Replication of influenza virus in a continuous cell line: high yield of infective virus from cells inoculated at high multiplicity. Virology. 1969 Sep;39(1):130–134. doi: 10.1016/0042-6822(69)90354-7. [DOI] [PubMed] [Google Scholar]
  3. Crick J., Cartwright B., Brown F. A study of the interference phenomenon in vesicular stomatitis virus replication. Arch Gesamte Virusforsch. 1969;27(2):221–235. doi: 10.1007/BF01249645. [DOI] [PubMed] [Google Scholar]
  4. Hackett A. J., Schaffer F. L., Madin S. H. The separation of infectious and autointerfering particles in vesicular stomatitis virus preparations. Virology. 1967 Jan;31(1):114–119. doi: 10.1016/0042-6822(67)90014-1. [DOI] [PubMed] [Google Scholar]
  5. Huang A. S., Baltimore D. Defective viral particles and viral disease processes. Nature. 1970 Apr 25;226(5243):325–327. doi: 10.1038/226325a0. [DOI] [PubMed] [Google Scholar]
  6. Huang A. S., Baltimore D., Stampfer M. Ribonucleic acid synthesis of vesicular stomatitis virus. 3. Multiple complementary messenger RNA molecules. Virology. 1970 Dec;42(4):946–957. doi: 10.1016/0042-6822(70)90343-0. [DOI] [PubMed] [Google Scholar]
  7. Huang A. S., Greenawalt J. W., Wagner R. R. Defective T particles of vesicular stomatitis virus. I. Preparation, morphology, and some biologic properties. Virology. 1966 Oct;30(2):161–172. doi: 10.1016/0042-6822(66)90092-4. [DOI] [PubMed] [Google Scholar]
  8. Kingsbury D. W., Portner A. On the genesis of incomplete Sendai virions. Virology. 1970 Dec;42(4):872–879. doi: 10.1016/0042-6822(70)90336-3. [DOI] [PubMed] [Google Scholar]
  9. Nonoyama M., Watanabe Y., Graham A. F. Defective virions of reovirus. J Virol. 1970 Aug;6(2):226–236. doi: 10.1128/jvi.6.2.226-236.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Petric M., Prevec L. Vesicular stomatitis virus--a new interfering particle, intracellular structures, and virus-specific RNA. Virology. 1970 Aug;41(4):615–630. doi: 10.1016/0042-6822(70)90427-7. [DOI] [PubMed] [Google Scholar]
  11. Stampfer M., Baltimore D., Huang A. S. Ribonucleic acid synthesis of vesicular stomatitis virus. I. Species of ribonucleic acid found in Chinese hamster ovary cells infected with plaque-forming and defective particles. J Virol. 1969 Aug;4(2):154–161. doi: 10.1128/jvi.4.2.154-161.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]

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