Abstract
Seven strains of Shope fibroma virus were compared for their effect on rabbit cells in vitro. All but one of the naturally occurring strains examined in this study produced a similar response in the infected cultures. This consisted of continued cell multiplication together with changes in cell morphology and growth pattern. In contrast, a recently isolated strain of fibroma virus, the M1 strain, was found to produce a gradual cell destruction under the same cultural conditions. A comparison of the cytocidal M1 strain with a representative noncytocidal strain in vitro showed no differences in the rate of multiplication, plaque type, antigenic composition, or heat lability. Only minor differences were found in the tumors produced in rabbits by these strains.
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Selected References
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- BLACK P. H., ROWE W. P. Transformation in hamster kidney monolayers by vacuolating virus, SV-40. Virology. 1963 Jan;19:107–109. doi: 10.1016/0042-6822(63)90031-x. [DOI] [PubMed] [Google Scholar]
- HINZE H. C., WALKER D. L. RESPONSE OF CULTURED RABBIT CELLS TO INFECTION WITH THE SHOPE FIBROMA VIRUS. I. PROLIFERATION AND MORPHOLOGICAL ALTERATION OF THE INFECTED CELLS. J Bacteriol. 1964 Oct;88:1185–1194. doi: 10.1128/jb.88.4.1185-1194.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KILHAM L., FISHER E. R. Pathogenesis of fibromas in cottontail rabbits. Am J Hyg. 1954 Jan;59(1):104–112. doi: 10.1093/oxfordjournals.aje.a119615. [DOI] [PubMed] [Google Scholar]
- KILHAM L., WOKE P. A. Laboratory transmission of fibromas (Shope) in cottontail rabbits by means of fleas and mosquitoes. Proc Soc Exp Biol Med. 1953 Jun;83(2):296–301. doi: 10.3181/00379727-83-20339. [DOI] [PubMed] [Google Scholar]
- PADGETT B. L., WALKER D. L. Use of centrifugal force to promote adsorption of myxoma virus to cell monolayers. Proc Soc Exp Biol Med. 1962 Nov;111:364–367. doi: 10.3181/00379727-111-27793. [DOI] [PubMed] [Google Scholar]
- Padgett B. L., Walker D. L. Effect of persistent fibroma virus infection on susceptibility of cells to other viruses. J Virol. 1970 Feb;5(2):199–204. doi: 10.1128/jvi.5.2.199-204.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHEIN H. M., ENDERS J. F., LEVINTHAL J. D., BURKET A. E. Transformation induced by simian virus 40 in newborn Syrian hamster renal cell cultures. Proc Natl Acad Sci U S A. 1963 Jan 15;49:28–34. doi: 10.1073/pnas.49.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tompkins W. A., Walker D. L., Hinze H. C. Cellular deoxyribonucleic acid synthesis and loss of contact inhibition in irradiated and contact-inhibited cell cultures infected with fibroma virus. J Virol. 1969 Nov;4(5):603–609. doi: 10.1128/jvi.4.5.603-609.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VOGT M., DULBECCO R. Properties of cells transformed by polyma virus. Cold Spring Harb Symp Quant Biol. 1962;27:367–374. doi: 10.1101/sqb.1962.027.001.034. [DOI] [PubMed] [Google Scholar]
- WOODROOFE G. M., FENNER F. VIRUSES OF THE MYXOMA-FIBROMA SUBGROUP OF THE POXVIRUSES. I. PLAQUE PRODUCTION IN CULTURED CELLS, PLAQUE-REDUCTION TESTS, AND CROSS-PROTECTION TESTS IN RABBITS. Aust J Exp Biol Med Sci. 1965 Apr;43:123–142. [PubMed] [Google Scholar]
- YUILL T. M., HANSON R. P. INFECTION OF SUCKLING COTTONTAIL RABBITS WITH SHOPE'S FIBROMA VIRUS. Proc Soc Exp Biol Med. 1964 Nov;117:376–380. doi: 10.3181/00379727-117-29585. [DOI] [PubMed] [Google Scholar]