Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1971 Jun;7(6):821–829. doi: 10.1128/jvi.7.6.821-829.1971

Inhibition of Poxvirus Maturation by Rifamycin Derivatives and Related Compounds

T H Pennington 1, E A C Follett 1
PMCID: PMC356202  PMID: 4105118

Abstract

The effect of a number of rifamycin derivatives and related compounds on the reversibility of the rifampin-induced virus maturation block was studied by using BHK-21 cells infected with vaccinia virus. All of the derivatives of 3-formyl rifamycin SV maintained this block, the required concentration varying from 100 to 1,000 μg/ml. These compounds vary only in the nature of the side-chain attached to the 3C atom on the naphthohydroquinone moiety; no obvious correlation between the nature of this side-chain and antiviral activity was found. Streptovaricin complex and tolypomycin R also maintained the maturation block; tolypomycin also produced marked alterations in the appearance of the viroplasm contained in rifampin-induced inclusions and immature virus particles.

Full text

PDF
821

Images in this article

823Image
on p.823
824Image
on p.824
825Image
on p.825
826Image
on p.826
827Image
on p.827
828Image
on p.828

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ben-Ishai Z., Heller E., Goldblum N., Becker Y. Rifampicin and poxvirus replication. Nature. 1969 Oct 4;224(5214):29–32. doi: 10.1038/224029a0. [DOI] [PubMed] [Google Scholar]
  2. Costanzo F., Fiume L., La Placa M., Mannini-Palenzona A., Novello F., Stirpe F. Ribonucleic acid polymerase induced by vaccinia virus: lack of inhibition by rifampicin and alpha-amanitin. J Virol. 1970 Feb;5(2):266–269. doi: 10.1128/jvi.5.2.266-269.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gamble J. G., McCluer R. H. In vitro studies with rifampicin on the stability of heart mitochondrial RNA. J Mol Biol. 1970 Nov 14;53(3):557–560. doi: 10.1016/0022-2836(70)90083-5. [DOI] [PubMed] [Google Scholar]
  4. Grimley P. M., Rosenblum E. N., Mims S. J., Moss B. Interruption by Rifampin of an early stage in vaccinia virus morphogenesis: accumulation of membranes which are precursors of virus envelopes. J Virol. 1970 Oct;6(4):519–533. doi: 10.1128/jvi.6.4.519-533.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Heller E., Argaman M., Levy H., Goldblum N. Selective inhibition of vaccinia virus by the antibiotic rifampicin. Nature. 1969 Apr 19;222(5190):273–274. doi: 10.1038/222273a0. [DOI] [PubMed] [Google Scholar]
  6. Maggi N., Pallanza R., Sensi P. New derivatives of rifamycin SV. Antimicrob Agents Chemother (Bethesda) 1965;5:765–769. [PubMed] [Google Scholar]
  7. Mcauslan B. R. Rifampicin inhibition of vaccinia replication. Biochem Biophys Res Commun. 1969 Oct 8;37(2):289–295. doi: 10.1016/0006-291x(69)90733-5. [DOI] [PubMed] [Google Scholar]
  8. Moss B., Katz E., Rosenblum E. N. Vaccinia virus directed RNA and protein synthesis in the presence of rifampicin. Biochem Biophys Res Commun. 1969 Aug 22;36(5):858–865. doi: 10.1016/0006-291x(69)90688-3. [DOI] [PubMed] [Google Scholar]
  9. Moss B., Rosenblum E. N., Katz E., Grimley P. M. Rifampicin: a specific inhibitor of vaccinia virus assembly. Nature. 1969 Dec 27;224(5226):1280–1284. doi: 10.1038/2241280a0. [DOI] [PubMed] [Google Scholar]
  10. Nagaya A., Pogo B. G., Dales S. Biogenesis of vaccinia: separation of early stages from maturation by means of rifampicin. Virology. 1970 Apr;40(4):1039–1051. doi: 10.1016/0042-6822(70)90150-9. [DOI] [PubMed] [Google Scholar]
  11. Pennington T. H., Follett E. A., Szilágyi J. F. Events in vaccinia virus-infected cells following the reversal of the antiviral action of rifampicin. J Gen Virol. 1970 Dec;9(3):225–237. doi: 10.1099/0022-1317-9-3-225. [DOI] [PubMed] [Google Scholar]
  12. Quintrell N. A., McAuslan B. R. Inhibition of Poxvirus replication by streptovaricin. J Virol. 1970 Oct;6(4):485–491. doi: 10.1128/jvi.6.4.485-491.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sensi P., Maggi N., Füresz S., Maffii G. Chemical modifications and biological properties of rifamycins. Antimicrob Agents Chemother (Bethesda) 1966;6:699–714. [PubMed] [Google Scholar]
  14. Shmerling Z. G. The effect of rifamycin on RNA synthesis in the rat liver mitochondria. Biochem Biophys Res Commun. 1969 Dec 4;37(6):965–969. doi: 10.1016/0006-291x(69)90225-3. [DOI] [PubMed] [Google Scholar]
  15. Sippel A., Hartmann G. Mode of action of rafamycin on the RNA polymerase reaction. Biochim Biophys Acta. 1968 Mar 18;157(1):218–219. doi: 10.1016/0005-2787(68)90286-4. [DOI] [PubMed] [Google Scholar]
  16. Subak-Sharpe J. H., Timbury M. C., Williams J. F. Rifampicin inhibits the growth of some mammalian viruses. Nature. 1969 Apr 26;222(5191):341–345. doi: 10.1038/222341a0. [DOI] [PubMed] [Google Scholar]
  17. Thiry L., Lancini G. Inhibition of vaccinia virus growth by 1-methyl-4-aminopiperazine. Nature. 1970 Sep 5;227(5262):1048–1050. doi: 10.1038/2271048a0. [DOI] [PubMed] [Google Scholar]
  18. Wehrli W., Knüsel F., Schmid K., Staehelin M. Interaction of rifamycin with bacterial RNA polymerase. Proc Natl Acad Sci U S A. 1968 Oct;61(2):667–673. doi: 10.1073/pnas.61.2.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. di Mauro E., Synder L., Marino P., Lamberti A., Coppo A., Tocchini-Valentini G. P. Rifampicin sensitivity of the components of DNA-dependent RNA polymerase. Nature. 1969 May 10;222(5193):533–537. doi: 10.1038/222533a0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES