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. 1971 Jul;8(1):1–6. doi: 10.1128/jvi.8.1.1-6.1971

Effect of Inactivation by Hydroxylamine on Early Functions of Poliovirus

Karin Borgert 1, Klaus Koschel 1, Helmut Täuber 1, Eberhard Wecker 1
PMCID: PMC356207  PMID: 4328412

Abstract

Evidence is presented that poliovirus particles with a single lethal hit by hydroxylamine do not induce in host cells either inhibition of cellular protein synthesis or viral ribonucleic acid (RNA) replication. The RNA of these viruses is not replicated even if the cells are simultaneously infected with both active and inactivated viruses. The damaged viral RNA seems to have lost both its template function and its function in the translation of normal viral proteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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