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. 1971 Aug;8(2):154–160. doi: 10.1128/jvi.8.2.154-160.1971

Defective Particles in BHK Cells Infected with Temperature-Sensitive Mutants of Vesicular Stomatitis Virus

M E Reichmann a,1, C R Pringle a, E A C Follett a
PMCID: PMC356226  PMID: 4107244

Abstract

Defective particles were the major product after undiluted passage of certain temperature-sensitive (ts) mutants of the Indiana C strain of vesicular stomatitis virus in BHK-21 cells at the permissive temperature (31 C). Essentially homogeneous preparations of defective particles were obtained with the wild-type and individual ts mutants. The defective particles associated with some of the ts mutants, however, were morphologically and physically distinguishable from wild type and from each other. All varieties of defective particle interfered with the multiplication of mutant and wild-type virus at the permissive temperature at early times of infection but failed to complement virions of different complementation groups at the restrictive temperature (39 C) at any time during infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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