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. 1971 Aug;8(2):215–224. doi: 10.1128/jvi.8.2.215-224.1971

Studies of Nondefective Adenovirus 2-Simian Virus 40 Hybrid Viruses IV. Characterization of the Simian Virus 40 Ribonucleic Acid Species Induced by Wild-Type Simian Virus 40 and by the Nondefective Hybrid Virus, Ad2+ND1

Michael N Oxman 1,2,3, Arthur S Levine 1,2,3, Clyde S Crumpacker 1,2,3, Myron J Levin 1,2,3, Patrick H Henry 1,2,3, Andrew M Lewis Jr 1,2,3
PMCID: PMC356233  PMID: 4329969

Abstract

Ad2+ND1, a nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, has been previously shown to contain a small segment of the SV40 genome covalently linked to Ad2 deoxyribonucleic acid (DNA). The SV40 portion of this hybrid virus has been characterized by relating the SV40-specific ribonucleic acid (RNA) sequences transcribed from the Ad2+ND1 DNA to those transcribed from the DNA of SV40 itself. RNA-DNA hybridization-competition studies indicate that the SV40 component of Ad2+ND1 consists of some, but not all, of that part of the SV40 genome which is transcribed early, i.e., prior to viral DNA replication, in SV40 lytic infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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