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. 1971 Sep;8(3):286–292. doi: 10.1128/jvi.8.3.286-292.1971

Effect of Rifampin on the Development of Ribonucleic Acid Bacteriophage Qβ

Jadwiga Passent a,1, Paul Kaesberg a
PMCID: PMC356241  PMID: 4940929

Abstract

The drug rifampin, when added at the time of infection, inhibits synthesis of the phage Qβ. Both viral ribonucleic acids and viral proteins are made in nearly the same amount as in the absence of rifampin, but the rate of assembly into phage particles is low.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Friesen J. D. Dependence of f2 bacteriophage RNA replication on amino acids. J Mol Biol. 1969 Dec 14;46(2):349–353. doi: 10.1016/0022-2836(69)90427-6. [DOI] [PubMed] [Google Scholar]
  2. Fromageot H. P., Zinder N. D. Growth of bacteriophage f2 in E. coli treated with rifampicin. Proc Natl Acad Sci U S A. 1968 Sep;61(1):184–191. doi: 10.1073/pnas.61.1.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Godson G. N., Sinsheimer R. L. The replication of bacteriophage MS2. VI. Interaction between bacteriophage RNA and cellular components in MS2-infected Escherichia coli. J Mol Biol. 1967 Feb 14;23(3):495–521. doi: 10.1016/s0022-2836(67)80121-9. [DOI] [PubMed] [Google Scholar]
  4. Hartmann G., Honikel K. O., Knüsel F., Nüesch J. The specific inhibition of the DNA-directed RNA synthesis by rifamycin. Biochim Biophys Acta. 1967;145(3):843–844. doi: 10.1016/0005-2787(67)90147-5. [DOI] [PubMed] [Google Scholar]
  5. Heller E., Argaman M., Levy H., Goldblum N. Selective inhibition of vaccinia virus by the antibiotic rifampicin. Nature. 1969 Apr 19;222(5190):273–274. doi: 10.1038/222273a0. [DOI] [PubMed] [Google Scholar]
  6. Hung P. P., Hale E. M., Overby L. R. Comparative antigenicities of Q beta phage, its structural components and reconstituted particles. Virology. 1969 Aug;38(4):703–706. doi: 10.1016/0042-6822(69)90191-3. [DOI] [PubMed] [Google Scholar]
  7. Jockusch H., Ball L. A., Kaesberg P. Synthesis of polypeptides directed by the RNA of phage Q beta. Virology. 1970 Oct;42(2):401–414. doi: 10.1016/0042-6822(70)90283-7. [DOI] [PubMed] [Google Scholar]
  8. Kamen R. Characterization of the subunits of Q-beta replicase. Nature. 1970 Nov 7;228(5271):527–533. doi: 10.1038/228527a0. [DOI] [PubMed] [Google Scholar]
  9. Katz E., Moss B. Formation of a vaccinia virus structural polypeptide from a higher molecular weight precursor: inhibition by rifampicin. Proc Natl Acad Sci U S A. 1970 Jul;66(3):677–684. doi: 10.1073/pnas.66.3.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kondo M., Gallerani R., Weissmann C. Subunit structure of Q-beta replicase. Nature. 1970 Nov 7;228(5271):525–527. doi: 10.1038/228525a0. [DOI] [PubMed] [Google Scholar]
  11. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  12. Lane L. C., Kaesberg P. Multiple genetic components in bromegrass mosaic virus. Nat New Biol. 1971 Jul 14;232(28):40–43. doi: 10.1038/newbio232040a0. [DOI] [PubMed] [Google Scholar]
  13. Maggi N., Pasqualucci C. R., Ballotta R., Sensi P. Rifampicin: a new orally active rifamycin. Chemotherapy. 1966;11(5):285–292. doi: 10.1159/000220462. [DOI] [PubMed] [Google Scholar]
  14. Skogerson L., Roufa D., Leder P. Characterization of the initial peptide of Q-beta RNA polymerase and control of its synthesis. Proc Natl Acad Sci U S A. 1971 Feb;68(2):276–279. doi: 10.1073/pnas.68.2.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Strauss E. G., Kaesberg P. Acrylamide gel electrophoresis of bacteriophage Q beta: electrophoresis of the intact virions and of the viral proteins. Virology. 1970 Oct;42(2):437–452. doi: 10.1016/0042-6822(70)90287-4. [DOI] [PubMed] [Google Scholar]
  16. Subak-Sharpe J. H., Timbury M. C., Williams J. F. Rifampicin inhibits the growth of some mammalian viruses. Nature. 1969 Apr 26;222(5191):341–345. doi: 10.1038/222341a0. [DOI] [PubMed] [Google Scholar]
  17. Sugiyama T. Translational control of MS2 RNA cistrons. Cold Spring Harb Symp Quant Biol. 1969;34:687–694. doi: 10.1101/sqb.1969.034.01.078. [DOI] [PubMed] [Google Scholar]
  18. Wehrli W., Knüsel F., Schmid K., Staehelin M. Interaction of rifamycin with bacterial RNA polymerase. Proc Natl Acad Sci U S A. 1968 Oct;61(2):667–673. doi: 10.1073/pnas.61.2.667. [DOI] [PMC free article] [PubMed] [Google Scholar]

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