Abstract
The effect of nalidixic acid on the growth of various deoxyribonucleic acid (DNA) bacteriophages has been investigated by one-step growth experiments. The Escherichia coli bacteriophages T5, λ, T7 and φR are strongly inhibited by nalidixic acid, whereas T4 and T2 are only partially inhibited. The Bacillus subtilis bacteriophages SP82, SP50, and φ29 are relatively unaffected by nalidixic acid. There is no correlation between those bacteriophages which can grow in the presence of nalidixic acid and the presence of an unusual base in the phage DNA.
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Selected References
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- Behki R. M., Lesley S. M. Effect of myxin on deoxyribonucleic acid synthesis in Escherichia coli infected with T4 bacteriophage. J Virol. 1971 Mar;7(3):372–378. doi: 10.1128/jvi.7.3.372-378.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown N. C. 6-(p-hydroxyphenylazo)-uracil: a selective inhibitor of host DNA replication in phage-infected Bacillus subtilis. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1454–1461. doi: 10.1073/pnas.67.3.1454. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cook T. M., Brown K. G., Boyle J. V., Goss W. A. Bactericidal action of nalidixic acid on Bacillus subtilis. J Bacteriol. 1966 Nov;92(5):1510–1514. doi: 10.1128/jb.92.5.1510-1514.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cowlishaw J., Ginoza W. Induction of lambda prophage by nalidixic acid. Virology. 1970 Jun;41(2):244–255. doi: 10.1016/0042-6822(70)90076-0. [DOI] [PubMed] [Google Scholar]
- GOSS W. A., DEITZ W. H., COOK T. M. MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS. J Bacteriol. 1965 Apr;89:1068–1074. doi: 10.1128/jb.89.4.1068-1074.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gage L. P., Fujita D. J. Effect of nalidixic acid on deoxyribonucleic acid synthesis in bacteriophage SPO1-infected Bacillus subtilis. J Bacteriol. 1969 Apr;98(1):96–103. doi: 10.1128/jb.98.1.96-103.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LESHER G. Y., FROELICH E. J., GRUETT M. D., BAILEY J. H., BRUNDAGE R. P. 1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS. J Med Pharm Chem. 1962 Sep;91:1063–1065. doi: 10.1021/jm01240a021. [DOI] [PubMed] [Google Scholar]
- SEKIGUCHI M., TAKAGI Y. Effect of mitomycin C on the synthesis of bacterial and viral deoxyribonucleic acid. Biochim Biophys Acta. 1960 Jul 15;41:434–443. doi: 10.1016/0006-3002(60)90040-8. [DOI] [PubMed] [Google Scholar]
- Studier F. W. The genetics and physiology of bacteriophage T7. Virology. 1969 Nov;39(3):562–574. doi: 10.1016/0042-6822(69)90104-4. [DOI] [PubMed] [Google Scholar]
- Taketo A., Watanabe H. Effect of nalidixic acid on the growth of bacterial viruses. J Biochem. 1967 Apr;61(4):520–522. doi: 10.1093/oxfordjournals.jbchem.a128579. [DOI] [PubMed] [Google Scholar]