Abstract
Purpose Much research has been performed on physical exposures during work (e.g. lifting, trunk flexion or body vibrations) as risk factors for low back pain (LBP), however results are inconsistent. Information on the effect of doses (e.g. spinal force or low back moments) on LBP may be more reliable but is lacking yet. The aim of the present study was to investigate the prospective relationship of cumulative low back loads (CLBL) with LBP and to compare the association of this mechanical load measure to exposure measures used previously. Methods The current study was part of the Study on Musculoskeletal disorders, Absenteeism and Health (SMASH) study in which 1,745 workers completed questionnaires. Physical load at the workplace was assessed by video-observations and force measurements. These measures were used to calculate CLBL. Furthermore, a 3-year follow-up was conducted to assess the occurrence of LBP. Logistic regressions were performed to assess associations of CLBL and physical risk factors established earlier (i.e. lifting and working in a flexed posture) with LBP. Furthermore, CLBL and the risk factors combined were assessed as predictors in logistic regression analyses to assess the association with LBP. Results Results showed that CLBL is a significant risk factor for LBP (OR: 2.06 (1.32–3.20)). Furthermore, CLBL had a more consistent association with LBP than two of the three risk factors reported earlier. Conclusions From these results it can be concluded that CLBL is a risk factor for the occurrence of LBP, having a more consistent association with LBP compared to most risk factors reported earlier.
Keywords: Low back loading, Ergonomics, Workers, Longitudinal studies, Observational studies
Introduction
In the past decades, epidemiological studies have contributed to our understanding of the aetiology of low back pain (LBP). Risk factors for the occurrence of LBP, can roughly be divided into: personal factors (e.g. age, smoking habits, physical capacity and body weight [1–4]), psychosocial factors (e.g. stress, social support and job satisfaction [5–8]), and physical factors [9–12]. Of these physical factors, twisting, bending, lifting and whole body vibrations are the most frequently reported ones associated with LBP [13–15]. Nevertheless, some recent reviews suggest that the evidence for a relationship between physical risk factors and LBP is not convincing [2, 11], and generally, data on exposure-response relationships are scarce and incomplete. It can be argued that the relationships of these physical exposures with LBP might be less reliable than the relationship of low back load dose (i.e. the effect that physical exposure has in the human body) with LBP, since different exposures (e.g. lifting and bending) affect the same dose [16]. While parameters of low back load, like low back moments or spine compression forces, could be used as such dose measures, information on the dose–response relationship of LBP is limited. Marras et al. investigated the predictive value of a variety of parameters of low back loading with the risk of LBP [17, 18]. Moreover, some other studies suggest that cumulative loads acting on the spine may contribute to LBP [19–21], however, these results are based on retrospective studies. Dose–response relationships obtained from prospective cohort studies have never been reported. The aim of the present study therefore was to investigate the association of cumulative low back load (CLBL) with LBP, in a large prospective cohort study. Furthermore, the association with LBP of this dose estimate will be compared to associations for exposures reported earlier to be related to LBP. We hypothesized that CLBL, quantified in terms of low back moments, is associated with LBP and that the association of this dose measure with LBP is more consistent than that of exposure measures that were previously established as risk factors for LBP.
Study Population and Methods
Population
Data used in this study are part of the Study on Musculoskeletal disorders, Absenteeism and Health (SMASH), a prospective cohort study among Dutch workers on risk factors of musculoskeletal disorders. The study was approved by the medical ethical committee of the Netherlands organization for applied scientific research (TNO). The SMASH study, in which workers from 34 companies with both blue-collar and white-collar jobs from different parts of the Netherlands participated, has been described in more detail previously [15, 22].
At baseline 1990 of the 2,048 workers who were invited for the study participated. 1,802 (91 %) of these workers completed all questionnaires at baseline. Forty-six workers were excluded because they had been employed in their current job <1 year or had been working <20 h a week. Eleven workers were excluded because they had another paid job for a substantial amount of time at another company than at which they were recruited. As a result, 1,745 workers were eligible to participate in the current study. Descriptive statistics of these workers are provided in Table 1.
Table 1.
Descriptive statistics (number of workers, gender, age, working hours per week and years of employment in the current job) of group of the workers who were eligible to participate in the current study (left column), workers of whom data were included in the statistical analysis (middle column) and workers of whom data were excluded from the statistical analysis (right column)
| Baseline workers | Workers in analysis | Workers not in analysis | |
|---|---|---|---|
| N | 1,745 | 1,086 | 659 |
| Gender | m = 1,222 (71 %)/f = 510 | m = 759 (70 %)/f = 327 | m = 463 (72 %)/f = 183 |
| Age (years) | 35.9 ± 8.4 | 35.6 ± 8.7 | 35.4 ± 8.9 |
| Hours per week | 38.3 ± 4.5 | 38.2 ± 4.7 | 38.2 ± 4.7 |
| Years in current job | 9.9 ± 7.7 | 9.6 ± 7.6 | 9.5 ± 8.0 |
Data Collection
At baseline, a number of potential risk factors were measured; questionnaire data were collected and assessment of physical load at the workplace was performed. Furthermore, a 3-year follow-up was conducted in which the prevalence of LBP was assessed annually.
Physical work load was assessed by video-observations and force measurements at the workplace. External force exertion at the hands was measured using force transducers or a weighting scale. Furthermore, workers were video-recorded at their workplace during 4 randomly selected moments of a workday. Each video-recording lasted 5–14 min, depending of the variability in working tasks. Thirty-five observers were recruited from a group of university students of the Faculty of Human Movement Sciences from the VU University Amsterdam. These observers had considerable knowledge on human kinematics and were trained using a standardized protocol to perform structured postural observations. These well-trained observers allocated all workers in task groups based on similar tasks and loads according to the International Standard Classification of Occupations. A continuous systematic observation of the video-recordings was used to assess trunk sagittal flexion, arm sagittal elevation, trunk rotation (in the transverse plane) and the presence of an external force in one-fourth of the workers of each task group. Furthermore, the time spend in a sitting position was observed. All data were extrapolated to an 8 h work day. A detailed description of these procedures was given by Hoogendoorn et al. [15].
Personal factors such as age and gender were assessed using self-administered questionnaires. A Dutch version of the Karasek’s Job Content Questionnaire for psychosocial work characteristics was used to assess job demands, decision authority, co-worker support and supervisor support [23]. The psychometric properties and the construction of these scales have been described by de Jonge et al. [24]. Exercise behaviour during leisure time was assessed with the Leisure Time Exercise Questionnaire [25]. Furthermore, driving a vehicle during work and during leisure time, flexion and rotation of the trunk and moving heavy loads during leisure time were assessed with the Loquest questionnaire [26]. A detailed description of all questionnaires has been given earlier [15, 22].
At baseline and at each year of the follow-up, the occurrence of LBP was assessed using a self-administered, adapted version of the Nordic Questionnaire [27]. LBP at baseline was defined when subjects reported regular or prolonged LBP in the previous 12 months before the start of the study. LBP during follow-up was defined as regular or prolonged LBP in the previous 12 months in at least one of the three annually follow-up questionnaires. The baseline population consisted of workers with and without LBP.
Assessment of Low Back Load
For the assessment of CLBL during work, a manikin consisting of a trunk/head, upper arm and a lower arm/hand segment was constructed based on segment orientations obtained from the continuous video-observations (Table 2) and segment anthropometrics. As observed postures were supposed to be representative for the task group, average body weight and length within each task group were used for the estimation of segment anthropometrics (segment mass, length and centre of mass [28, 29]) and an estimation of the L5-S1 position [30] using regression equations.
Table 2.
Observational categories
| Variable | Observation | CLBL calculation | |
|---|---|---|---|
| Description | Category | Values | |
| Trunk flexion (sagittal plane) | Neutral | <30° | 0° |
| Mild flexion | 30°–60° | 45° | |
| Extreme flexion | 60°–90° | 75° | |
| Very extreme flexion | >90° | 90° | |
| Trunk rotation (transverse plane) | Neutral | <30° | 0° |
| Twisting | >30° | 30° | |
| Arm elevation (sagittal plane) | Neutral | <30° | 15° |
| Mild elevation | 30°–60° | 45° | |
| Extreme elevation | 60°–90° | 75° | |
| Very extreme elevation | >90° | 90° | |
The table shows a description and corresponding values for the observed variables. The last column shows body orientation values that were used for the calculation of CLBL
CLBL Cumulative low back load
For the complete observed period, a top–down calculation of net moments at the L5-S1 joint was performed using a general equation of motion [31]. In this calculation, segment gravitational forces of the constructed manikin combined with the measured external forces were taken into account. The calculated moments in the lower back were squared to accommodate for the fact that the moment levels have larger effect on injury risk than the number of repetitions [32]. Subsequently, CLBL was assessed by calculating the area under the moment curve. Mean task group values of the CLBL during the observed period were assigned to all workers in the same task group and were extrapolated to an entire work week based on the number of working hours of each individual in that task group during a week. All calculations were performed using custom developed Matlab software (version 7.7.0) [33].
Statistical Analyses
The crude effect of CLBL (categorized into five categories, based on 20th percentiles –quintiles-) on LBP was assessed using a logistic regression with LBP during the follow-up (independent of LBP at baseline) as dependent variable, calculating ORs and corresponding 95 % CI. The choice for the number of categories is a balance between the power requirements (a sufficient number of workers in each category should remain) and optimizing contrast between the categories. The relationship of CLBL and LBP was checked on linearity by comparing regression coefficients between quintiles. In case of a linear relationship, logistic regression analyses were performed using CLBL as a continuous variable rather than categorised into five categories. In line with earlier reports on the present population [15], the variables age, gender, exercise behaviour during leisure time, quantitative job demands, decision authority, skill discretion, supervisor support, co-worker support, driving a vehicle during work and leisure time, flexion/rotation of the trunk during leisure time and moving heavy loads during leisure time were considered confounders. A second logistic regression analysis was performed to calculate ORs and corresponding 95 % CI for CLBL (independent variable) on LBP during the follow-up (dependent variable), adjusted for these confounders.
To compare the association of the dose measure CLBL with LBP during the follow-up to exposure measures reported earlier, six additional logistic regression analyses were performed. The earlier found risk factors percentage of the working time in a flexed position, number of lifts in an 8 h working day, and number of lifts ≥25 kg in an 8 h working day were used for comparison since they were reported to be significant risk factors for LBP in the same study population earlier [15]. In the first three analyses, the three exposures reported earlier were separately used as independent variables consecutively, without and with correction for CLBL. In the other three analyses CLBL was used as independent variable corrected for one of the three above mentioned physical risk factors, consecutively. Associations of all risk factors with LBP separately and corrected as indicated above were compared to assess the risk factor with the most consistent association with LBP. All statistical analyses were performed using SPSS (version 17.0.1).
Results
Population
Of the 1,745 workers eligible for participation in the current study, data on the physical load at workplace were available for 1,463 workers, while data on the occurrence of LBP in at least one follow-up measurement were available for 1,196 workers. For 1,192 workers, data on both physical load at workplace and on the occurrence of LBP were available. Of 1,086 workers, data on physical load at work, the occurrence of LBP and all confounders were available. 416 of these workers (38 %) reported LBP at baseline and 537 workers (49 %) reported LBP during at least one of the 3 years of follow-up. Data of these workers were used for further analysis (Table 1). In contrast to earlier work on the same population [15], workers with LBP at baseline were included in the present study.
LBP Risk Model
The regression coefficients of the five CLBL categories, obtained from the logistic regression analyses, revealed a non-linear relationship of CLBL and LBP (Table 3). Therefore, categorised CLBL into quintiles (Table 4) was used as independent variable in the logistic regression models. A significant crude relation of CLBL and LBP in the group with the highest CLBL compared to the group with the lowest CLBL was shown (OR of 1.60, 95 % CI: 1.10–2.35). Also, CLBL adjusted for confounders yielded a significant relationship with the occurrence of LBP in the group with the highest CLBL compared to the group with the lowest CLBL (OR: 2.06, 95 % CI: 1.32–3.20; Table 3).
Table 3.
Association of CLBL with LBP based on logistic regressions
| Risk factor | LBP | No LBP | B | OR (95 % CI), n = 1,086† |
|---|---|---|---|---|
| Regression model | ||||
| CLBL | ||||
| 1st quintile | 109 | 107 | Reference | |
| 2nd quintile | 106 | 122 | −0.15 | 0.86 (0.59–1.25) |
| 3th quintile | 93 | 129 | −0.34 | 0.71 (0.49–1.04) |
| 4th quintile | 93 | 107 | −0.15 | 0.86 (0.59–1.26) |
| 5th quintile | 136 | 84 | 0.47 | 1.60 (1.10–2.35)* |
| CLBL | ||||
| 1st quintile | Reference# | |||
| 2nd quintile | 0.05 | 1.05 (0.70–1.58) | ||
| 3th quintile | −0.13 | 0.87 (0.57–1.33) | ||
| 4th quintile | 0.03 | 1.03 (0.68–1.57) | ||
| 5th quintile | 0.72 | 2.06 (1.32–3.20)* | ||
B regression coefficient, OR odds ratio, CI confidence interval
* Significant risk factor for LBP
†Of 1,086 workers data on the occurrence of LBP during follow-up, physical exposure at work and all confounders were available
#Logistic regression adjusted for the confounders: age, gender, exercise behaviour during leisure time, quantitative job demands, decision authority, skill discretion, supervisor support, co-worker support, driving a vehicle during work and leisure time, flexion/rotation of the trunk during leisure time and moving heavy loads during leisure time
CLBL Cumulative low back load
LBP Low back pain
Table 4.
Category values of the five different categories (based on quintiles)
| n | Minimum | Maximum | Mean | SD | |
|---|---|---|---|---|---|
| Category values | |||||
| 1th quintiles | 216 | 0.09 | 0.49 | 0.29 | 0.11 |
| 2nd quintiles | 228 | 0.52 | 0.71 | 0.62 | 0.05 |
| 3th quintiles | 222 | 0.74 | 1.13 | 1.03 | 0.13 |
| 4th quintiles | 200 | 1.14 | 1.96 | 1.52 | 0.29 |
| 5th quintiles | 220 | 1.99 | 10.83 | 3.65 | 2.38 |
| Total | 1,086 | 0.09 | 10.83 | 1.43 | 1.16 |
Number of subjects (n), minimum and maximum, mean and standard deviation of CLBL (all in MNm) in all five quintiles are listed
CLBL Cumulative low back load
LBP Low back pain
SD Standard deviation
To assess the predictive value of CLBL for LBP in comparison to exposures reported earlier, additional logistic regression analyses were performed in which these three risk factors were used as independent variables. Logistic regression analyses adjusted for confounders showed that all three risk factors significantly predicted LBP with ORs of 2.35 (1.46–3.79), 2.22 (1.33–3.36) and 2.38 (1.48–3.82) respectively in the most exposed groups (Table 5). However, when corrected for confounders and CLBL, only lifting >15 times ≥25 kg in an 8 h working day compared to no lifts of ≥25 kg was a significant risk factor for LBP (OR: 2.03 (1.23–3.36)), while percentage of the working time in a flexed position and number of lifts in a 8 h working day did not significantly predict LBP. Moreover, when separately corrected for each of these three risk factors, the CLBL remained a significant predictor for LBP in the group with the highest CLBL compared to the group with the lowest CLBL, showing ORs of 1.89 (1.04–3.45), 1.96 (1.15–3.36) and 1.85 (1.17–2.92) respectively (Table 5).
Table 5.
Associations of the three earlier found risk factors (percentage of the working time in a flexed position, number of lifts in a 8 h working day, number of lifts ≥25 kg in a 8 h working day) with LBP based on logistic regression, adjusted for confounders (left columns) and adjusted for confounders and CLBL (right columns). Besides, association of CLBL with LBP adjusted for all earlier found risk factors separately are shown
| Risk factor | LBP | No LBP | OR (95 % CI), n = 1,086† | OR (95 % CI), n = 1,086† |
|---|---|---|---|---|
| Time in trunk flexion | ||||
| ≤5 % time ≥30° | 256 | 287 | Referencea | Referenceb |
| 5–10 % time ≥30° | 96 | 110 | 1.01 (0.73–1.47) | 1.15 (0.74–1.78) |
| >10 % time ≥30° & ≤5 % time ≥60° | 120 | 120 | 1.15 (0.83–1.58) | 0.91 (0.57–1.46) |
| >5 % time ≥60° | 65 | 32 | 2.35 (1.46–3.79)* | 1.45 (0.77–2.73) |
| Number of lifts | ||||
| Never | 151 | 161 | Referencea | Referenceb |
| Never ≥10 kg/working day | 81 | 94 | 0.74 (0.50–1.09) | 0.69 (0.45–1.06) |
| Never ≥25 kg/working day | 146 | 156 | 0.96 (0.68–1.36) | 0.77 (0.51–1.17) |
| 1–15 times ≥25 kg/working day | 96 | 107 | 0.86 (0.59–1.27) | 0.73 (0.44–1.19) |
| >15 times ≥25 kg/working day | 63 | 31 | 2.22 (1.33–3.72)* | 1.60 (0.88–2.92) |
| Number of lifts ≥25 kg | ||||
| Never | 378 | 411 | Referencea | Referenceb |
| 1–15 time/working day | 96 | 107 | 0.93 (0.67–1.29) | 0.92 (0.63–1.34) |
| >15 times/working day | 63 | 31 | 2.38 (1.48–3.82)* | 2.03 (1.23–3.36)* |
| CLBL | ||||
| 1st quintile | Reference1 | |||
| 2nd quintile | 1.06 (0.70–1.59) | |||
| 3th quintile | 0.83 (0.51–1.33) | |||
| 4th quintile | 1.03 (0.60–1.78) | |||
| 5th quintile | 1.89 (1.04–3.45)* | |||
| CLBL | ||||
| 1st quintile | Reference2 | |||
| 2nd quintile | 0.97 (0.62–1.51) | |||
| 3th quintile | 0.88 (0.55–1.41) | |||
| 4th quintile | 1.05 (0.62–1.76) | |||
| 5th quintile | 1.96 (1.15–3.36)* | |||
| CLBL | ||||
| 1st quintile | Reference3 | |||
| 2nd quintile | 1.06 (0.71–1.60) | |||
| 3th quintile | 0.85 (0.56–1.31) | |||
| 4th quintile | 0.99 (0.62–1.57) | |||
| 5th quintile | 1.85 (1.17–2.92)* | |||
B regression coefficient, OR odds ratio, CI confidence interval
* Significant risk factor for LBP
†Of 1,086 workers data on the occurrence of LBP during follow-up, physical exposure at work and all confounders were available
aAdjusted for the confounders: age, gender, exercise behaviour during leisure time, quantitative job demands, decision authority, skill discretion, supervisor support, co-worker support, driving a vehicle during work and leisure time, flexion/rotation of the trunk during leisure time and moving heavy loads during leisure time
bAdjusted for both above mentioned confounders and CLBL
1Adjusted for both above mentioned confounders and ‘Percentage of the working time in a flexed position’
2Adjusted for both above mentioned confounders and ‘Number of lifts in an 8 h working day’
3Adjusted for both above mentioned confounders and ‘Number of lifts ≥25 kg in an 8 h working day’
CLBL Cumulative low back load
LBP Low back pain
Discussion
The first aim of the present study was to investigate whether a low back load dose, in this study expressed in CLBL is a predictor for LBP among workers. In the results, CLBL showed a significant association with the occurrence of LBP in the group with the largest CLBL. From these findings we can conclude that CLBL is a significant predictor of LBP. However, a significantly higher risk of LBP is only shown in the group with the highest levels of CLBL, which are levels of 2.00 MNm and more. As an example, for a moderate lifting task that would lead to a low back load of 200 Nm, this level of CLBL will be reached when 2.000.000/2002 = 50 of these lifts are performed during a work week. Ergonomic interventions should therefore be targeted mainly to workers who encounter these levels of CLBL which can emerge from combinations of awkward postures and/or high exposure tasks at work.
The second aim, to compare the association with LBP of CLBL to risk factors reported earlier, was attained using additional logistic regression analyses. These results show that CLBL remains a significant risk factor of LBP when corrected for the earlier found risk factors. Moreover, while the risk factors reported earlier are significant risk factors for LBP when corrected for confounders, only one risk factor remains significant when corrected for both confounders and CLBL. From these results we can conclude that CLBL has a more consistent association with LBP than the risk factors time in a flexed position and number of lifts in a working day. This finding supports our hypothesis that a low back load dose measure provides a stronger relationship with LBP than exposure measures of low back load since several exposures (e.g. lifting and bending) are incorporated in the dose. The fact that the risk factor number of lifts ≥25 kg in an 8 h working day had a comparable association with LBP may indicate that this exposure metric reflects incidental peak loads which may constitute an independent risk for LBP. Again, this underscores the importance of focussing on peak loads.
Methodological Considerations
The strength of the present study is that the results are based on a large prospective cohort study. This design, in which the prevalence of LBP was measured during a 3-year follow-up allows insight into potential causes of LBP [34]. Of the 1,745 workers who were eligible to participate in this study, data on physical load at the workplace, on the occurrence of LBP and on confounders were available for 1,086 workers. Selection or attribution bias may be possible due to this substantial loss to follow-up. However, the group of workers analyzed and the group of workers who were excluded from the statistical analysis due to incomplete data show comparable descriptive characteristics with respect to age, gender, working hours per weeks and years of employment (Table 1), thereby reducing the likeliness of these kinds of biases.
In contrast to earlier studies on this study population [15], workers suffering from LBP at baseline were included in our analyses. It has been shown that a history of LBP is a good predictor of future LBP since LBP often comes in several episodes [35, 36]. Excluding workers with pain at baseline thus seems unreasonable since it cannot be excluded that workers without complaints at baseline, have not had any complaints 2 or 3 years before the baseline measurements. Therefore, we can assume that when excluding these workers, the healthy worker effect will be reinforced. Besides, including workers with a history of LBP makes the present results applicable to a larger part of the working population since excluding these workers would reduces the external validity of the current results. Including workers with pain at baseline seems therefore reasonable. Furthermore, an extra analysis in which only the workers without baseline complaints were analyzed (i.e. the workers who did not report LBP at baseline) showed changes in ORs <0.1 in the associations of CLBL with LBP. These findings, showing that associations of CLBL and LBP do not change considerably, support the consistency of the current results.
A limitation of the present study is the subjective assessment of LBP. It has been shown that diagnosing LBP is complicated. However, subjectively assessed LBP has been shown to have a strong relation with clinically examined LBP [37] and sickness absence due to LBP [38]. Furthermore, the CLBL assessment method contains some limitations. First, observations based on videos may suffer from errors and potential bias [39]. Furthermore, movements which are not in the sagittal plane are difficult to assess [40] and the outcome of the measurement is dependent on the selected time at the measurement-day, the number of subjects per task group and the number of measurements per subject [41]. The latter problems were addressed by measuring workers at four random chosen moments of the day and measuring several workers in each task group, to obtain more precise estimates of the exposure within groups [42]. Structured postural observations have been performed by multiple observers. Although, it has been shown that postural video observations are reliable among observers in work-site situations [43, 44], inter-observer reliability was not evaluated in the group of observers we recruited. Therefore, because several trained observers classified the body postures, inter- and intra-observer variation cannot be ruled out.
Another source of error in our study might have emerged from the fact that workers were observed at four randomly chosen occasions of the work day for a finite amount of time rather than a complete observation of the whole work day. This choice was made based on a pilot study, in which it has been shown that the largest amount of variation in physical work exposure, is variation in exposure within workers rather than variation in exposure between workers [45]. The appropriateness of our measurement strategy was furthermore supported by showing small within group variability and large between group variability in data on the same cohort [22]. Measuring on multiple occasions on a single work day is therefore considered a feasible and justifiable approach to reduce the amount of observation time. Furthermore, it has been shown that measuring work load at four occasions during a day is sufficient to obtain a reliable estimate of the work exposure [41].
A final source of error of the CLBL assessment results from the biomechanical calculation, which contains assumptions concerning the workers’ anthropometrics and segment orientations. Furthermore, segment dynamics were not taken into account in this calculation, which may have led to an underestimation of the calculated low back load. The above mentioned sources of errors in the calculation of CLBL suggest that associations of dose measures with LBP might become even higher when more reliable dose estimates are available. Besides, as an indicator of back load, low back moments were used, although it may be argued that injury risk and thus potentially LBP is more accurately predicted by spinal forces, either in compression [46] or shear direction [18, 19]. However, a strong correlation of low back moments with shear forces and compression forces has been reported [47] reducing the risk of large errors due to the use of moments instead of spine forces.
Comparison with Previous Findings
The relationship between awkward body postures during work (e.g. trunk flexion, trunk rotation and lifting) and LBP has been reported in several prospective studies in the last decades [13, 15]. However, several reviews [9, 11, 12, 48] showed that results are inconsistent. The association of low back load dose measures and the risk of LBP can give more insight in the aetiology of LBP. An association of cumulative and peak low back load with LBP has been has been described before [19–21]. However, these associations are based on retrospective studies. The present results are comparable to the earlier findings and thus confirm these findings in a prospective study, thereby providing strong support for a causal relationship between CLBL and LBP.
Conclusions
From the current study it can be concluded that CLBL is a significant risk factor for LBP with more consistent associations with LBP than risk factors reported earlier. Moreover, CLBL appeared to reflect both the effects of working in a trunk flexed position and number of lifts during work on LBP risk. The risk factor number of lifts ≥25 kg had additional value in predicting the risk of LBP besides CLBL. The results of the present study may have implications for prevention programs for LBP. Interventions aimed at changes in posture and lifting forces, but also reduction of duration of exposure to adverse postures should, according to these findings be considered.
Acknowledgments
The authors would like to thank Marjolein Douwes and Swenneke van den Heuvel for their assistance in data collection and analyses.
Open Access
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
References
- 1.Hamberg-van Reenen HH, Ariens GA, Blatter BM, van Mechelen W, Bongers PM. A systematic review of the relation between physical capacity and future low back and neck/shoulder pain. Pain. 2007;130(1–2):93–107. doi: 10.1016/j.pain.2006.11.004. [DOI] [PubMed] [Google Scholar]
- 2.Wai EK, Rodriguez S, Dagenais S, Hall H. Evidence-informed management of chronic low back pain with physical activity, smoking cessation, and weight loss. Spine J. 2008;8(1):195–202. doi: 10.1016/j.spinee.2007.10.024. [DOI] [PubMed] [Google Scholar]
- 3.Leboeuf-Yde C. Back pain–individual and genetic factors. J Electromyogr Kinesiol. 2004;14(1):129–133. doi: 10.1016/j.jelekin.2003.09.019. [DOI] [PubMed] [Google Scholar]
- 4.Manek NJ, MacGregor AJ. Epidemiology of back disorders: prevalence, risk factors, and prognosis. Curr Opin Rheumatol. 2005;17(2):134–140. doi: 10.1097/01.bor.0000154215.08986.06. [DOI] [PubMed] [Google Scholar]
- 5.Hoogendoorn WE, van Poppel MN, Bongers PM, Koes BW, Bouter LM. Systematic review of psychosocial factors at work and private life as risk factors for back pain. Spine. 2000;25(16):2114–2125. doi: 10.1097/00007632-200008150-00017. [DOI] [PubMed] [Google Scholar]
- 6.Hartvigsen J, Lings S, Leboeuf-Yde C, Bakketeig L. Psychosocial factors at work in relation to low back pain and consequences of low back pain: a systematic, critical review of prospective cohort studies. Occup Environ Med. 2004;61(1):e2. [PMC free article] [PubMed] [Google Scholar]
- 7.Macfarlane GJ, Pallewatte N, Paudyal P, Blyth FM, Coggon D, Crombez G, Linton S, Leino-Arjas P, Silman AJ, Smeets RJ, van der Windt D. Evaluation of work-related psychosocial factors and regional musculoskeletal pain: results from a EULAR Task Force. Ann Rheum Dis. 2009;68(6):885–891. doi: 10.1136/ard.2008.090829. [DOI] [PubMed] [Google Scholar]
- 8.Linton SJ. Occupational psychological factors increase the risk for back pain: a systematic review. J Occup Rehabil. 2001;11(1):53–66. doi: 10.1023/A:1016656225318. [DOI] [PubMed] [Google Scholar]
- 9.Kuiper JI, Burdorf A, Verbeek JHAM, Frings-Dresen MHW, van der Beek AJ, Viikari-Juntura ERA. Epidemiologic evidence on manual material handling as a risk factor for back disorders: a systematic review. Int J Ind Ergonomics. 1999;24(4):389–404. doi: 10.1016/S0169-8141(99)00006-2. [DOI] [Google Scholar]
- 10.Hoogendoorn WE, van Poppel MN, Bongers PM, Koes BW, Bouter LM. Physical load during work and leisure time as risk factors for back pain. Scand J Work Environ Health. 1999;25(5):387–403. doi: 10.5271/sjweh.451. [DOI] [PubMed] [Google Scholar]
- 11.Bakker EW, Verhagen AP, van Trijffel E, Lucas C, Koes BW. Spinal mechanical load as a risk factor for low back pain: a systematic review of prospective cohort studies. Spine. 2009;34(8):E281–E293. doi: 10.1097/BRS.0b013e318195b257. [DOI] [PubMed] [Google Scholar]
- 12.Griffith LE, Shanon HS, Wells RP, Walter SD, Cole DC, Côté P, Frank J, Hogg-Johnson S, Langlois L. Individual participant data meta-analysis of mechanical workplace risk factors and low back pain. Am J Public Health. 2012;102(2):309–318. doi: 10.2105/AJPH.2011.300343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.van Nieuwenhuyse A, Somville PR, Crombez G, Burdorf A, Verbeke G, Johannik K, Van den Bergh O, Masschelein R, Mairiaux P, Moens GF. The role of physical workload and pain related fear in the development of low back pain in young workers: evidence from the BelCoBack Study; results after one year of follow up. Occup Environ Med. 2006;63(1):45–52. doi: 10.1136/oem.2004.015693. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Tiemessen IJ, Hulshof CT, Frings-Dresen MH. Low back pain in drivers exposed to whole body vibration: analysis of a dose-response pattern. Occup Environ Med. 2008;65(10):667–675. doi: 10.1136/oem.2007.035147. [DOI] [PubMed] [Google Scholar]
- 15.Hoogendoorn WE, Bongers PM, de Vet HC, Douwes M, Koes BW, Miedema MC, Ariens GA, Bouter LM. Flexion and rotation of the trunk and lifting at work are risk factors for low back pain: results of a prospective cohort study. Spine. 2000;25(23):3087–3092. doi: 10.1097/00007632-200012010-00018. [DOI] [PubMed] [Google Scholar]
- 16.Burdorf A. The role of assessment of biomechanical exposure at the workplace in the prevention of musculoskeletal disorders. Scand J Work Environ Health. 2010;36(1):1–2. doi: 10.5271/sjweh.2882. [DOI] [PubMed] [Google Scholar]
- 17.Marras WS, Lavender SA, Leurgans SE, Fathallah FA, Ferguson SA, Allread WG, Rajulu SL. Biomechanical risk factors for occupationally related low back disorders. Ergonomics. 1995;38(2):377–410. doi: 10.1080/00140139508925111. [DOI] [PubMed] [Google Scholar]
- 18.Marras WS, Lavender SA, Ferguson SA, Splittstoesser RE, Yang G. Quantitative dynamic measures of physical exposure predict low back functional impairment. Spine. 2010;35(8):914–923. doi: 10.1097/BRS.0b013e3181ce1201. [DOI] [PubMed] [Google Scholar]
- 19.Norman R, Wells R, Neumann P, Frank J, Shannon H, Kerr M. A comparison of peak vs cumulative physical work exposure risk factors for the reporting of low back pain in the automotive industry. Clin Biomech. 1998;13(8):561–573. doi: 10.1016/S0268-0033(98)00020-5. [DOI] [PubMed] [Google Scholar]
- 20.Neumann WP, Wells RP, Norman RW, Frank J, Shannon H, Kerrb MS. A posture and load sampling approach to determining low-back pain risk in occupational settings. Int J Ind Ergonomics. 2001;27:65–77. doi: 10.1016/S0169-8141(00)00038-X. [DOI] [Google Scholar]
- 21.Kumar S. Cumulative load as a risk factor for back pain. Spine. 1990;15(12):1311–1316. doi: 10.1097/00007632-199012000-00014. [DOI] [PubMed] [Google Scholar]
- 22.Ariëns GA, Bongers PM, Douwes M, Miedema MC, Hoogendoorn WE, van der Wal G, Bouter LM, van Mechelen W. Are neck flexion, neck rotation, and sitting at work risk factors for neck pain? Results of a prospective cohort study. Occup Environ Med. 2001;58(3):200–207. doi: 10.1136/oem.58.3.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 23.Karasek R. Job content instrument user guides: revision 1.1. 1985.
- 24.de Jonge J, Reuvers MM, Houtman IL, Bongers PM, Kompier MA. Linear and nonlinear relations between psychosocial job characteristics, subjective outcomes, and sickness absence: baseline results from SMASH. Study on Musculoskeletal Disorders, Absenteeism, Stress, and Health. J Occup Health Psychol. 2000;5(2):256–268. doi: 10.1037/1076-8998.5.2.256. [DOI] [PubMed] [Google Scholar]
- 25.Godin G, Jobin J, Bouillon J. Assessment of leisure time exercise behavior by self-report: a concurrent validity study. Can J Public Health. 1986;77(5):359–362. [PubMed] [Google Scholar]
- 26.Hildebrandt VH. Physical load and work: Questionnaire on musculoskeletal load and health complaints (Lichamelijke belasting en arbeid:vragenlijst bewegingsapparaat). Voorburg: Dutch Ministry of Social Affairs and Employment; 1991. p. S122–3.
- 27.Kuorinka I, Jonsson B, Kilbom A, Vinterberg H, Biering-Sorensen F, Andersson G, Jorgensen K. Standardised Nordic questionnaires for the analysis of musculoskeletal symptoms. Appl Ergon. 1987;18(3):233–237. doi: 10.1016/0003-6870(87)90010-X. [DOI] [PubMed] [Google Scholar]
- 28.Dumas R, Cheze L, Verriest JP. Adjustments to McConville et al. and Young et al. body segment inertial parameters. J Biomech. 2007;40(3):543–553. doi: 10.1016/j.jbiomech.2006.02.013. [DOI] [PubMed] [Google Scholar]
- 29.de Leva P. Adjustments to Zatsiorsky-Seluyanov’s segment inertia parameters. J Biomech. 1996;29(9):1223–1230. doi: 10.1016/0021-9290(95)00178-6. [DOI] [PubMed] [Google Scholar]
- 30.de Looze MP, Kingma I, Bussmann JBJ, Toussaint HM. Validation of a dynamic linked segment model to calculate joint moments in lifting. Clin Biomech. 1992;7:161–169. doi: 10.1016/0268-0033(92)90031-X. [DOI] [PubMed] [Google Scholar]
- 31.Hof AL. An explicit expression for the moment in multibody systems. J Biomech. 1992;25(10):1209–1211. doi: 10.1016/0021-9290(92)90076-D. [DOI] [PubMed] [Google Scholar]
- 32.Brinckmann P, Johannleweling N, Hilweg D, Biggemann M. Fatigue fracture of human lumbar vertebrae. Clin Biomech. 1987;S1:94–96. doi: 10.1016/0268-0033(87)90134-3. [DOI] [PubMed] [Google Scholar]
- 33.Matlab 7.7.0, The MathWorks Inc., Natick, MA, 2000.
- 34.Rothman KJ, Greenland S. Causation and causal inference in epidemiology. Am J Public Health. 2005;95(Suppl 1):144–150. doi: 10.2105/AJPH.2004.059204. [DOI] [PubMed] [Google Scholar]
- 35.Smedley J, Egger P, Cooper C, Coggon D. Prospective cohort study of predictors of incident low back pain in nurses. BMJ. 1997;314(7089):1225–1228. doi: 10.1136/bmj.314.7089.1225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 36.van Tulder M, Koes B, Bombardier C. Low back pain. Best Pract Res Cl Rh. 2002;16(5):761–775. doi: 10.1053/berh.2002.0267. [DOI] [PubMed] [Google Scholar]
- 37.Holmstrom E, Moritz U. Low back pain–correspondence between questionnaire, interview and clinical examination. Scand J Work Environ Health. 1991;23(3):119–125. [PubMed] [Google Scholar]
- 38.Roelen CA, Koopmans PC, Groothoff JW. Subjective health complaints in relation to sickness absence. Work. 2010;37(1):15–21. doi: 10.3233/WOR-2010-1052. [DOI] [PubMed] [Google Scholar]
- 39.van der Beek AJ, Frings-Dresen MH. Assessment of mechanical exposure in ergonomic epidemiology. Occup Environ Med. 1998;55(5):291–299. doi: 10.1136/oem.55.5.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 40.Paul JA, Douwes M. Two-dimensional photographic posture recording and description: a validity study. Appl Ergon. 1993;24(2):83–90. doi: 10.1016/0003-6870(93)90079-O. [DOI] [PubMed] [Google Scholar]
- 41.Hoozemans MJ, Burdorf A, van der Beek AJ, Frings-Dresen MH, Mathiassen SE. Group-based measurement strategies in exposure assessment explored by bootstrapping. Scand J Work Environ Health. 2001;27(2):125–132. doi: 10.5271/sjweh.599. [DOI] [PubMed] [Google Scholar]
- 42.Kromhout H, Tielemans E, Preller L, Heederik D. Estimates of individual dose from current measurements of exposure. Occup Hyg. 1996;3(1–3):23–39. [Google Scholar]
- 43.Bao S, Howard N, Spielholz P, Silverstein B, Polissar N. Interrater reliability of posture observations. Hum Factors. 2009;51(3):292–309. doi: 10.1177/0018720809340273. [DOI] [PubMed] [Google Scholar]
- 44.van der Beek AJ, van Gaalen LC, Frings-Dresen MH. Working postures and activities of lorry drivers: a reliability study of on-site observation and recording on a pocket computer. Appl Ergon. 1992;23(5):331–336. doi: 10.1016/0003-6870(92)90294-6. [DOI] [PubMed] [Google Scholar]
- 45.van der Beek AJ, Braam IT, Douwes M, Bongers PM, Frings-Dresen MH, Verbeek JH, Luyts S. Validity of a diary estimating exposure to tasks, activities, and postures of the trunk. Int Arch Occup Environ Health. 1994;66(3):173–178. doi: 10.1007/BF00380776. [DOI] [PubMed] [Google Scholar]
- 46.van Dieen JH, Weinans H, Toussaint HM. Fractures of the lumbar vertebral endplate in the etiology of low back pain: a hypothesis on the causative role of spinal compression in aspecific low back pain. Med Hypotheses. 1999;53(3):246–252. doi: 10.1054/mehy.1998.0754. [DOI] [PubMed] [Google Scholar]
- 47.van Dieen JH, Kingma I. Effects of antagonistic co-contraction on differences between electromyography based and optimization based estimates of spinal forces. Ergonomics. 2005;48(4):411–426. doi: 10.1080/00140130512331332918. [DOI] [PubMed] [Google Scholar]
- 48.Wai EK, Roffey DM, Bishop P, Kwon BK, Dagenais S. Causal assessment of occupational lifting and low back pain: results of a systematic review. Spine J. 2010;10(6):554–566. doi: 10.1016/j.spinee.2010.03.033. [DOI] [PubMed] [Google Scholar]