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. 1972 Jul;10(1):124–133. doi: 10.1128/jvi.10.1.124-133.1972

Nuclear Disruption After Infection of Escherichia coli with a Bacteriophage T4 Mutant Unable to Induce Endonuclease II

D Peter Snustad 1,2, Huber R Warner 1,2, Kathleen A Parson 1,2, Dwight L Anderson 1,2
PMCID: PMC356433  PMID: 4114321

Abstract

Nuclear disruption after infection of Escherichia coli with a bacteriophage T4 mutant deficient in the ability to induce endonuclease II indicates that either (i) the endonuclease II-catalyzed reaction is not the first step in host deoxyribonucleic acid (DNA) breakdown or (ii) nuclear disruption is independent of nucleolytic cleavage of the host chromosome. M-band analysis demonstrates that the host DNA remains membrane-bound after infection with either an endonuclease II-deficient mutant or T4 phage ghosts.

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Selected References

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