Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Dec 13;1(1):65. doi: 10.1186/2193-1801-1-65

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Zhao et al.; licensee Springer. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FCdR arrested HCT116 cells at G2/M phase.A. HCT116 cells were treated with 0.05 μM or 0.5 μM FCdR for 48 h and cell cycle was analyzed by flow cytometry. Compared with control, percentage of cells at G2/M phase increased significantly after FCdR treatment. B. HCT116 cells were treated with indicated amount of FCdR for 48 h and the cyclins checked by western blot. CyclinB1, which accumulates at G2/M phase, significantly increased after FCdR treatment. C. HCT116 p53+/+ and p53^−/− cells were treated with 0.5 μM FCdR or 375 μM 5-Fu for 48 h and apoptosis assayed by PARP and CASP3 western blot. 5-Fu treatment caused cleavage of PARP and CASP3, but not FCdR.