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. 1972 Oct;10(4):730–736. doi: 10.1128/jvi.10.4.730-736.1972

Deoxyribonucleic Acid Repair in Bacteriophage T4: Observations on the Roles of the x and v Genes and of Host Factors

Kristien Mortelmans 1, Errol C Friedberg 1
PMCID: PMC356527  PMID: 4343548

Abstract

Studies were carried out to determine the effect of mutation in the host pol I gene on survival of ultraviolet (UV)-irradiated bacteriophage T4. Whereas a slightly reduced survival was observed in Escherichia coli strain P-3478 (pol A1) compared to strain W-3110 (pol A+), no such difference was observed in two strains isogenic except for the pol A gene. It was also shown that, whereas bacteriophage T4x is sensitive to UV irradiation, X irradiation, and treatment with methyl-methanesulfonate (MMS), phage T4v1 is sensitive only to UV irradiation. The survival of damaged phage T4x is neither affected by the presence of the rec A, rec B, or pol A mutations in the host, nor is there evidence that phage T4 effects repair of rec A or pol A mutants previously treated with either UV or MMS.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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