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. 1973 Sep;12(3):659–662. doi: 10.1128/jvi.12.3.659-662.1973

Growth of Pseudotypes of Vesicular Stomatitis Virus with N-Tropic Murine Leukemia Virus Coats in Cells Resistant to N-Tropic Viruses

Alice S Huang 1,2, Peter Besmer 1,2, Louise Chu 1,2, David Baltimore 1,2
PMCID: PMC356675  PMID: 4355863

Abstract

Formation of pseudotypes between murine RNA tumor viruses and vesicular stomatitis virus (VSV) has been confirmed. Pseudotypes of VSV genomes coated by the surface envelope from an N-tropic tumor virus grew equally well in cells homozygous for either the Fv-1n or Fv-1b alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step after attachment and penetration.

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Selected References

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