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. 1973 Nov;12(5):1065–1071. doi: 10.1128/jvi.12.5.1065-1071.1973

Polyoma Pseudovirions II. Influence of Host Cell on Pseudovirus Production

David B Yelton a,1, H Vasken Aposhian a
PMCID: PMC356737  PMID: 4358161

Abstract

The type of host cell influenced the relative amounts of pseudovirions and polyoma virions produced. The infection of primary mouse embryo cells resulted in the production of particles that were predominantly pseudovirions. Infection of baby mouse kidney or 3T3D cells yielded mainly infectious polyoma virus. The length of time that infection was allowed to continue also affected the amount of pseudovirions relative to polyoma virions. The longer the viral infection was allowed to proceed, the greater the quantity of pseudovirions produced. Pseudovirion production could be correlated with the fragmentation of host cell DNA to a size of approximately 3 × 106 daltons. The fragmentation of host cell DNA was much more extensive in primary mouse embryo cells than in the other cell types.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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