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. 1973 Nov;12(5):1104–1117. doi: 10.1128/jvi.12.5.1104-1117.1973

Cell Surface Antigens Associated with Murine Leukemia Virus: Definition of the GL and GT Antigenic Systems

Robert C Nowinski 1, Elizabeth D Peters 1
PMCID: PMC356742  PMID: 4358163

Abstract

Two new serological specificities were identified on the surface of murine leukemia virus (MuLV)-infected cells by direct and absorption immunofluorescence tests. Both antigens were detected with antisera prepared in rats that were growing transplants of syngenic MuLV-induced leukemias. Antigen GL was defined with the AKR leukemia K36 as the test cell; antigen GT was defined with the W/Fu leukemia C58(NT)D as the test cell. GL and GT antigens were serologically and genetically independent of the MuLV-induced Gross and GIX cell-surface antigens. GL and GT antigens were found in normal lymphoid cells of mice from high-leukemic strains, but not in lymphoid tissues of mice from most low-leukemic strains. Tumors and leukemias of mice of low-leukemic strains often were GL and GT positive. Similarly, infection of normal cells with MuLV resulted in expression of GL and GT. With ferritin-labeled antibody the GL and GT antigens were observed on virus-free segments of the cell surface. Genetically, GL and GT antigens were each controlled by two dominant unlinked genes in AKR mice; these same antigens were each controlled by three or more dominant unlinked genes in C58 mice. Penetrance of GL and GT regulatory genes was dependent upon the Fv-1 genotype of the host. Expression of GL antigen was closely associated with virus production, whereas expression of GT antigen was less closely associated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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