Table 6.
Effect of interaction of CYP2E1 polymorphism and ERCC2/XPD 312 and 751 polymorphisms on p21 biomarker in vinylchloride (VC) workers.
|
CYP2E1 genotype |
ERCC2/XPD genotype |
p21 Biomarker |
Crude OR |
Adjusted ORa |
|||
|---|---|---|---|---|---|---|---|
| − | + | OR | − | + | OR | ||
| clci | 312 Asp-Asp | 165 | 46 | 1.0 | 1.0 | ||
| Asp-Asn | 161 | 79 | 1.8 | 1.2–2.7 | 1.8 | 1.2–2.7 | |
| Asn-Asn | 31 | 23 | 2.7 | 1.4–4.9 | 2.7 | 1.4–5.2 | |
| clc2/c2c2 | 312 Asp-Asp | 7 | 5 | 2.6 | 0.8–8.2 | 2.5 | 2.0–13.3 |
| Asp-Asn | 8 | 12 | 5.4 | 2.2–12.9 | 5.1 | 2.0–13.3 | |
| Asn-Asn | 3 | 6 | 7.2 | 2.1–25.0 | 7.5 | 1.8–31.6 | |
| clcl | 751 Lys-Lys | 160 | 50 | 1.0 | 1.0 | ||
| Lys-Gln | 162 | 77 | 1.5 | 1.0–2.3 | 1.5 | 1.0–2.3 | |
| Gln-Gln | 35 | 21 | 1.9 | 1.0–3.6 | 1.9 | 1.0–3.7 | |
| clc2/c2c2 | 751 Lys-Lys | 9 | 3 | 1.1 | 0.3–4.1 | 1.0 | 0.3–3.8 |
| Lys-Gln | 6 | 11 | 5.9 | 2.3–15.2 | 5.6 | 1.9–16.2 | |
| Gln-Gln | 9 | 12 | 9.6 | 3.1–30.0 | 10.4 | 2.7–40.5 | |
a
Adjusted for age, smoking, drinking and cumulative VC exposure; p for trend <0.0001.