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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Microcirculation. 2013 Feb;20(2):170–182. doi: 10.1111/micc.12016

Figure 1. Effect of chronic occlusion and exercise training on bradykinin-mediated vasodilation in porcine coronary arterioles.

Figure 1

Bradykinin-mediated dilation was not significantly altered by exercise training in arterioles of the nonoccluded region (A). In contrast, exercise training significantly enhanced bradykinin-mediated dilation in the collateral-dependent region (B). IC50 values (insets) revealed that sensitivity to bradykinin was not altered by exercise training in the nonoccluded region, but was significantly increased in collateral-dependent arterioles of exercise trained (EX) compared with sedentary (SED) pigs. Bradykinin-mediated dilation and IC50 values (insets) were significantly attenuated in collateral-dependent compared with nonoccluded coronary arterioles of sedentary, but not exercise-trained pigs. Values are means ± S.E.M. of the number of animals in parentheses. A subset of these data has been published previously (53). * P ≤ 0.05.