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Effects of ranolazine on G protein-coupled receptors (GPCR)
| GPCR | Preparation | Potency (Ki, μM) | Comments | References |
|---|---|---|---|---|
| α1 | Rat salivary gland | 8.2 | Radioligand binding | Zhao et al.62 |
| Rat liver | 19.5 | |||
| Rat ventricle | 10.5 | |||
| β1 | Rat ventricle | 8.6 | Binding | Zhao et al.62 |
| Rat heart | 1.4 | Letienne et al.63 | ||
| β2 | Guinea pig lung | 14.8 | Binding | Zhao et al.62 |
| Guinea pig lung | 0.5 | Binding | Letienne et al.63 | |
| DDT1MF-2 cells | 9.0 | Binding | Gilead, unpublished data |
