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. 2013 Feb 13;154(3):1310–1320. doi: 10.1210/en.2012-1886

Figure 2.

Figure 2.

Follistatin-like 3 (FSTL3) deletion leads to the maintenance of testicular size with age. Hematoxylin and eosin staining of testes sections from wild-type (WT, left) and FSTL3 knockout (KO, right) animals at 6 mo (top) and 16 mo (bottom), shown at 20× magnification (I, interstitial/Leydig cells; ST, seminiferous tubule). There appears to be more interstitial space in the testes of WT (some with dotted outline) than in FSTL3 KO animals at 16 mo. Scale bar represents 100 μm (A). Seminiferous tubule size distribution in FSTL3 KO and WT mice. The shortest diameter of seminiferous tubules of circular cross-section were measured from three hematoxylin-and-eosin–stained testicular sections (6 μm thick) at least 120 μm apart from each other for each 16-mo-old WT (transparent, n = 5 mice, 829 tubules) and FSTL3 KO (gray, n = 5 mice, 951 tubules) mouse. Error bars = SEM; *P < .05 (B).