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. 1988 Jul;1(3):300–312. doi: 10.1128/cmr.1.3.300

Epstein-Barr virus and human diseases: recent advances in diagnosis.

M Okano 1, G M Thiele 1, J R Davis 1, H L Grierson 1, D T Purtilo 1
PMCID: PMC358052  PMID: 2848624

Abstract

Since the discovery of Epstein-Barr virus (EBV) from a cultured Burkitt's lymphoma cell line in 1964, the virus has been associated with Burkitt's lymphoma, nasopharyngeal carcinoma, and infectious mononucleosis. During the recent decade, EBV has been etiologically implicated in a broad spectrum of human diseases. The precise role of this virus in these diseases is not well understood, but clearly, defective immunosurveillance against the virus may permit an uncontrolled proliferation of EBV-infected cells. As a result, a growing number of cases of EBV-associated B-cell proliferative diseases or lymphoma have been noted in patients with primary and acquired immunodeficiencies. These lymphoproliferative diseases and others, such as chronic mononucleosis syndrome, are leading to new areas of investigation which are providing information regarding the pathogenetic mechanisms of EBV-induced diseases. The early accurate diagnosis of EBV infection can be achieved by performing EBV-specific serology, detecting for EBV-determined nuclear antigen in tissues, establishing spontaneous lymphoid cell lines, and using molecular hybridization techniques for demonstrating the presence of viral genome in affected lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alfieri C., Joncas J. H. Biomolecular analysis of a defective nontransforming Epstein-Barr virus (EBV) from a patient with chronic active EBV infection. J Virol. 1987 Oct;61(10):3306–3309. doi: 10.1128/jvi.61.10.3306-3309.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Andiman W., Gradoville L., Heston L., Neydorff R., Savage M. E., Kitchingman G., Shedd D., Miller G. Use of cloned probes to detect Epstein-Barr viral DNA in tissues of patients with neoplastic and lymphoproliferative diseases. J Infect Dis. 1983 Dec;148(6):967–977. doi: 10.1093/infdis/148.6.967. [DOI] [PubMed] [Google Scholar]
  3. BURKITT D. A sarcoma involving the jaws in African children. Br J Surg. 1958 Nov;46(197):218–223. doi: 10.1002/bjs.18004619704. [DOI] [PubMed] [Google Scholar]
  4. Berkel A. I., Henle W., Henle G., Klein G., Ersoy F., Sanal O. Epstein-Barr virus-related antibody patterns in ataxia-telangiectasia. Clin Exp Immunol. 1979 Feb;35(2):196–201. [PMC free article] [PubMed] [Google Scholar]
  5. Biggar R. J., Gardiner C., Lennette E. T., Collins W. E., Nkrumah F. K., Henle W. Malaria, sex, and place of residence as factors in antibody response to Epstein-Barr virus in Ghana, West Africa. Lancet. 1981 Jul 18;2(8238):115–118. doi: 10.1016/s0140-6736(81)90299-3. [DOI] [PubMed] [Google Scholar]
  6. Bird A. G., McLachlan S. M., Britton S. Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein-Barr virus-induced B-cell lines. Nature. 1981 Jan 22;289(5795):300–301. doi: 10.1038/289300a0. [DOI] [PubMed] [Google Scholar]
  7. Bornkamm G. W., Delius H., Zimber U., Hudewentz J., Epstein M. A. Comparison of Epstein-Barr virus strains of different origin by analysis of the viral DNAs. J Virol. 1980 Sep;35(3):603–618. doi: 10.1128/jvi.35.3.603-618.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bornkamm G. W., von Knebel-Doeberitz M., Lenoir G. M. No evidence for differences in the Epstein-Barr virus genome carried in Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from the same patients. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4930–4934. doi: 10.1073/pnas.81.15.4930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Burkitt D. P. Etiology of Burkitt's lymphoma--an alternative hypothesis to a vectored virus. J Natl Cancer Inst. 1969 Jan;42(1):19–28. [PubMed] [Google Scholar]
  10. Calne R. Y., Rolles K., White D. J., Thiru S., Evans D. B., McMaster P., Dunn D. C., Craddock G. N., Henderson R. G., Aziz S. Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. Lancet. 1979 Nov 17;2(8151):1033–1036. doi: 10.1016/s0140-6736(79)92440-1. [DOI] [PubMed] [Google Scholar]
  11. Calne R. Y., White D. J., Evans D. B., Thiru S., Henderson R. G., Hamilton D. V., Rolles K., McMaster P., Duffy T. J., MacDougall B. R. Cyclosporin A in cadaveric organ transplantation. Br Med J (Clin Res Ed) 1981 Mar 21;282(6268):934–936. doi: 10.1136/bmj.282.6268.934. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Chang R. S., Lewis J. P., Abildgaard C. F. Prevalence of oropharyngeal excreters of leukocyte-transforming agents among a human population. N Engl J Med. 1973 Dec 20;289(25):1325–1329. doi: 10.1056/NEJM197312202892501. [DOI] [PubMed] [Google Scholar]
  13. Cheah M. S., Ley T. J., Tronick S. R., Robbins K. C. fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. Nature. 1986 Jan 16;319(6050):238–240. doi: 10.1038/319238a0. [DOI] [PubMed] [Google Scholar]
  14. Cleary M. L., Chao J., Warnke R., Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc Natl Acad Sci U S A. 1984 Jan;81(2):593–597. doi: 10.1073/pnas.81.2.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Cleary M. L., Sklar J. Lymphoproliferative disorders in cardiac transplant recipients are multiclonal lymphomas. Lancet. 1984 Sep 1;2(8401):489–493. doi: 10.1016/s0140-6736(84)92566-2. [DOI] [PubMed] [Google Scholar]
  16. Datta A. K., Colby B. M., Shaw J. E., Pagano J. S. Acyclovir inhibition of Epstein-Barr virus replication. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5163–5166. doi: 10.1073/pnas.77.9.5163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Dillner J., Kallin B., Alexander H., Ernberg I., Uno M., Ono Y., Klein G., Lerner R. A. An Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA5) partly encoded by the transformation-associated Bam WYH region of EBV DNA: preferential expression in lymphoblastoid cell lines. Proc Natl Acad Sci U S A. 1986 Sep;83(17):6641–6645. doi: 10.1073/pnas.83.17.6641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. DuBois R. E., Seeley J. K., Brus I., Sakamoto K., Ballow M., Harada S., Bechtold T. A., Pearson G., Purtilo D. T. Chronic mononucleosis syndrome. South Med J. 1984 Nov;77(11):1376–1382. doi: 10.1097/00007611-198411000-00007. [DOI] [PubMed] [Google Scholar]
  19. EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
  20. Ernberg I., Kallin B., Dillner J., Falk K., Ehlin-Henriksson B., Hammarskjöld M. L., Klein G. Lymphoblastoid cell lines and Burkitt-lymphoma-derived cell lines differ in the expression of a second Epstein-Barr virus encoded nuclear antigen. Int J Cancer. 1986 Nov 15;38(5):729–737. doi: 10.1002/ijc.2910380517. [DOI] [PubMed] [Google Scholar]
  21. Evans A. S. Infectious mononucleosis and related syndromes. Am J Med Sci. 1978 Nov-Dec;276(3):325–339. doi: 10.1097/00000441-197811000-00010. [DOI] [PubMed] [Google Scholar]
  22. Fauci A. S., Masur H., Gelmann E. P., Markham P. D., Hahn B. H., Lane H. C. NIH conference. The acquired immunodeficiency syndrome: an update. Ann Intern Med. 1985 Jun;102(6):800–813. doi: 10.7326/0003-4819-102-6-800. [DOI] [PubMed] [Google Scholar]
  23. Fingeroth J. D., Weis J. J., Tedder T. F., Strominger J. L., Biro P. A., Fearon D. T. Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci U S A. 1984 Jul;81(14):4510–4514. doi: 10.1073/pnas.81.14.4510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Flug F., Pelicci P. G., Bonetti F., Knowles D. M., 2nd, Dalla-Favera R. T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms. Proc Natl Acad Sci U S A. 1985 May;82(10):3460–3464. doi: 10.1073/pnas.82.10.3460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Gardella T., Medveczky P., Sairenji T., Mulder C. Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis. J Virol. 1984 Apr;50(1):248–254. doi: 10.1128/jvi.50.1.248-254.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Gerber P., Lucas S., Nonoyama M., Perlin E., Goldstein L. I. Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis. Lancet. 1972 Nov 11;2(7785):988–989. doi: 10.1016/s0140-6736(72)92402-6. [DOI] [PubMed] [Google Scholar]
  27. Gerber P., Walsh J. H., Rosenblum E. N., Purcell R. H. Association of EB-virus infection with the post-perfusion syndrome. Lancet. 1969 Mar 22;1(7595):593–595. doi: 10.1016/s0140-6736(69)91532-3. [DOI] [PubMed] [Google Scholar]
  28. Greenspan J. S., Greenspan D., Lennette E. T., Abrams D. I., Conant M. A., Petersen V., Freese U. K. Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesion. N Engl J Med. 1985 Dec 19;313(25):1564–1571. doi: 10.1056/NEJM198512193132502. [DOI] [PubMed] [Google Scholar]
  29. Grierson H., Purtilo D. T. Epstein-Barr virus infections in males with the X-linked lymphoproliferative syndrome. Ann Intern Med. 1987 Apr;106(4):538–545. doi: 10.7326/0003-4819-106-4-538. [DOI] [PubMed] [Google Scholar]
  30. Hanto D. W., Frizzera G., Gajl-Peczalska K. J., Simmons R. L. Epstein-Barr virus, immunodeficiency, and B cell lymphoproliferation. Transplantation. 1985 May;39(5):461–472. doi: 10.1097/00007890-198505000-00001. [DOI] [PubMed] [Google Scholar]
  31. Hanto D. W., Gajl-Peczalska K. J., Frizzera G., Arthur D. C., Balfour H. H., Jr, McClain K., Simmons R. L., Najarian J. S. Epstein-Barr virus (EBV) induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation. Clinical, pathologic, and virologic findings and implications for therapy. Ann Surg. 1983 Sep;198(3):356–369. doi: 10.1097/00000658-198309000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Harrington D. S., Weisenburger D. D., Purtilo D. T. Malignant lymphoma in the X-linked lymphoproliferative syndrome. Cancer. 1987 Apr 15;59(8):1419–1429. doi: 10.1002/1097-0142(19870415)59:8<1419::aid-cncr2820590807>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  33. Hecht F., McCaw B. K., Koler R. D. Ataxia-telangiectasia--clonal growth of translocation lymphocytes. N Engl J Med. 1973 Aug 9;289(6):286–291. doi: 10.1056/NEJM197308092890603. [DOI] [PubMed] [Google Scholar]
  34. Henie G., Henle W., Horwitz C. A. Antibodies to Epstein-Barr virus-associated nuclear antigen in infectious mononucleosis. J Infect Dis. 1974 Sep;130(3):231–239. doi: 10.1093/infdis/130.3.231. [DOI] [PubMed] [Google Scholar]
  35. Henle G., Lennette E. T., Alspaugh M. A., Henle W. Rheumatoid factor as a cause of positive reactions in tests for Epstein-Barr virus-specific IgM antibodies. Clin Exp Immunol. 1979 Jun;36(3):415–422. [PMC free article] [PubMed] [Google Scholar]
  36. Henle W., Henle G., Andersson J., Ernberg I., Klein G., Horwitz C. A., Marklund G., Rymo L., Wellinder C., Straus S. E. Antibody responses to Epstein-Barr virus-determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection. Proc Natl Acad Sci U S A. 1987 Jan;84(2):570–574. doi: 10.1073/pnas.84.2.570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Henle W., Henle G. Epstein-Barr virus-specific serology in immunologically compromised individuals. Cancer Res. 1981 Nov;41(11 Pt 1):4222–4225. [PubMed] [Google Scholar]
  38. Hennessy K., Fennewald S., Hummel M., Cole T., Kieff E. A membrane protein encoded by Epstein-Barr virus in latent growth-transforming infection. Proc Natl Acad Sci U S A. 1984 Nov;81(22):7207–7211. doi: 10.1073/pnas.81.22.7207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Holmes G. P., Kaplan J. E., Stewart J. A., Hunt B., Pinsky P. F., Schonberger L. B. A cluster of patients with a chronic mononucleosis-like syndrome. Is Epstein-Barr virus the cause? JAMA. 1987 May 1;257(17):2297–2302. [PubMed] [Google Scholar]
  40. Horwitz C. A., Henle W., Henle G., Schmitz H. Clinical evaluation of patients with infectious mononucleosis and development of antibodies to the R component of the Epstein-Barr virus-induced early antigen complex. Am J Med. 1975 Mar;58(3):330–338. doi: 10.1016/0002-9343(75)90599-9. [DOI] [PubMed] [Google Scholar]
  41. Ito Y., Kawanishi M., Harayama T., Takabayashi S. Combined effect of the extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells. Cancer Lett. 1981 Apr;12(3):175–180. doi: 10.1016/0304-3835(81)90066-5. [DOI] [PubMed] [Google Scholar]
  42. Joncas J., Lapointe N., Gervais F., Leyritz M. Unusual prevalence of Epstein-Barr virus early antigen (EBV-EA) antibodies in ataxia telangiectasia. J Immunol. 1977 Nov;119(5):1857–1859. [PubMed] [Google Scholar]
  43. Jondal M., Klein G., Oldstone M. B., Bokish V., Yefenof E. Surface markers on human B and T lymphocytes. VIII. Association between complement and Epstein-Barr virus receptors on human lymphoid cells. Scand J Immunol. 1976;5(4):401–410. doi: 10.1111/j.1365-3083.1976.tb00294.x. [DOI] [PubMed] [Google Scholar]
  44. Jondal M., Svedmyr E., Klein E., Klein G. Epstein-Barr virus (EBV) specific T and K cell cytotoxicity in vitro. Bibl Haematol. 1975 Oct;(43):265–269. doi: 10.1159/000399145. [DOI] [PubMed] [Google Scholar]
  45. Jones J. F., Ray C. G., Minnich L. L., Hicks M. J., Kibler R., Lucas D. O. Evidence for active Epstein-Barr virus infection in patients with persistent, unexplained illnesses: elevated anti-early antigen antibodies. Ann Intern Med. 1985 Jan;102(1):1–7. doi: 10.7326/0003-4819-102-1-. [DOI] [PubMed] [Google Scholar]
  46. Joshi V. V., Kauffman S., Oleske J. M., Fikrig S., Denny T., Gadol C., Lee E. Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome. Cancer. 1987 Apr 15;59(8):1455–1462. doi: 10.1002/1097-0142(19870415)59:8<1455::aid-cncr2820590811>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  47. Katz B. Z., Niederman J. C., Olson B. A., Miller G. Fragment length polymorphisms among independent isolates of Epstein-Barr virus from immunocompromised and normal hosts. J Infect Dis. 1988 Feb;157(2):299–308. doi: 10.1093/infdis/157.2.299. [DOI] [PubMed] [Google Scholar]
  48. Klein G. Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution. Proc Natl Acad Sci U S A. 1979 May;76(5):2442–2446. doi: 10.1073/pnas.76.5.2442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Klein G., Svedmyr E., Jondal M., Persson P. O. EBV-determined nuclear antigen (EBNA)-positive cells in the peripheral blood of infectious mononucleosis patients. Int J Cancer. 1976 Jan 15;17(1):21–26. doi: 10.1002/ijc.2910170105. [DOI] [PubMed] [Google Scholar]
  50. Komaroff A. L. The 'chronic mononucleosis' syndromes. Hosp Pract (Off Ed) 1987 May 30;22(5A):71–75. [PubMed] [Google Scholar]
  51. Luka J., Chase R. C., Pearson G. R. A sensitive enzyme-linked immunosorbent assay (ELISA) against the major EBV-associated antigens. I. Correlation between ELISA and immunofluorescence titers using purified antigens. J Immunol Methods. 1984 Feb 24;67(1):145–156. doi: 10.1016/0022-1759(84)90093-0. [DOI] [PubMed] [Google Scholar]
  52. Markin R. S., Linder J., Zuerlein K., Mroczek E., Grierson H. L., Brichacek B., Purtilo D. T. Hepatitis in fatal infectious mononucleosis. Gastroenterology. 1987 Dec;93(6):1210–1217. doi: 10.1016/0016-5085(87)90246-0. [DOI] [PubMed] [Google Scholar]
  53. Menezes J., Jondal M., Leibold W., Dorval G. Epstein-Barr virus interactions with human lymphocyte subpopulations: virus adsorption, kinetics of expression of Epstein-Barr virus-associated nuclear antigen, and lymphocyte transformation. Infect Immun. 1976 Feb;13(2):303–310. doi: 10.1128/iai.13.2.303-310.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Merino F., Klein G. O., Henle W., Ramirez-Duque P., Forsgren M., Amesty C. Elevated antibody titers to Epstein-Barr virus and low natural killer cell activity in patients with Chediak-Higashi syndrome. Clin Immunol Immunopathol. 1983 Jun;27(3):326–339. doi: 10.1016/0090-1229(83)90085-5. [DOI] [PubMed] [Google Scholar]
  55. Montagnier L., Gruest J., Chamaret S., Dauguet C., Axler C., Guétard D., Nugeyre M. T., Barré-Sinoussi F., Chermann J. C., Brunet J. B. Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines. Science. 1984 Jul 6;225(4657):63–66. doi: 10.1126/science.6328661. [DOI] [PubMed] [Google Scholar]
  56. Moss D. J., Rickinson A. B., Pope J. H. Long-term T-cell-mediated immunity to Epstein-Barr virus in man. I. Complete regression of virus-induced transformation in cultures of seropositive donor leukocytes. Int J Cancer. 1978 Dec;22(6):662–668. doi: 10.1002/ijc.2910220604. [DOI] [PubMed] [Google Scholar]
  57. National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. The Non-Hodgkin's Lymphoma Pathologic Classification Project. Cancer. 1982 May 15;49(10):2112–2135. doi: 10.1002/1097-0142(19820515)49:10<2112::aid-cncr2820491024>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  58. Ochs H. D., Sullivan J. L., Wedgwood R. J., Seeley J. K., Sakamoto K., Purtilo D. T. X-linked lymphoproliferative syndrome: abnormal antibody responses to bacteriophage phi X 174. Birth Defects Orig Artic Ser. 1983;19(3):321–323. [PubMed] [Google Scholar]
  59. Okano M., Mizuno F., Osato T., Takahashi Y., Sakiyama Y., Matsumoto S. Wiskott-Aldrich syndrome and Epstein-Barr virus-induced lymphoproliferation. Lancet. 1984 Oct 20;2(8408):933–934. doi: 10.1016/s0140-6736(84)90692-5. [DOI] [PubMed] [Google Scholar]
  60. Pearson G. R., Orr T. W. Antibody-dependent lymphocyte cytotoxicity against cells expressing Epstein-Barr virus antigens. J Natl Cancer Inst. 1976 Mar;56(3):485–488. doi: 10.1093/jnci/56.3.485. [DOI] [PubMed] [Google Scholar]
  61. Purtilo D. T., Cassel C. K., Yang J. P., Harper R. X-linked recessive progressive combined variable immunodeficiency (Duncan's disease). Lancet. 1975 Apr 26;1(7913):935–940. doi: 10.1016/s0140-6736(75)92004-8. [DOI] [PubMed] [Google Scholar]
  62. Purtilo D. T. Epstein-Barr virus: the spectrum of its manifestations in human beings. South Med J. 1987 Aug;80(8):943–947. doi: 10.1097/00007611-198708000-00003. [DOI] [PubMed] [Google Scholar]
  63. Purtilo D. T., Manolov G., Manolova Y., Harada S., Lipscomb H., Tatsumi E. Role of Epstein-Barr virus in the etiology of Burkitt's lymphoma. IARC Sci Publ. 1985;(60):231–247. [PubMed] [Google Scholar]
  64. Purtilo D. T., Tatsumi E., Manolov G., Manolova Y., Harada S., Lipscomb H., Krueger G. Epstein-Barr virus as an etiological agent in the pathogenesis of lymphoproliferative and aproliferative diseases in immune deficient patients. Int Rev Exp Pathol. 1985;27:113–183. [PubMed] [Google Scholar]
  65. Raab-Traub N., Flynn K. The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell. 1986 Dec 26;47(6):883–889. doi: 10.1016/0092-8674(86)90803-2. [DOI] [PubMed] [Google Scholar]
  66. Reece E. R., Gartner J. G., Seemayer T. A., Joncas J. H., Pagano J. S. Epstein-Barr virus in a malignant lymphoproliferative disorder of B-cells occurring after thymic epithelial transplantation for combined immunodeficiency. Cancer Res. 1981 Nov;41(11 Pt 1):4243–4247. [PubMed] [Google Scholar]
  67. Rosén A., Gergely P., Jondal M., Klein G., Britton S. Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro. Nature. 1977 May 5;267(5606):52–54. doi: 10.1038/267052a0. [DOI] [PubMed] [Google Scholar]
  68. SVOBODA D., KIRCHNER F., SHANMUGARATNAM K. ULTRASTRUCTURE OF NASOPHARYNGEAL CARCINOMAS IN AMERICAN AND CHINESE PATIENTS; AN APPLICATION OF ELECTRON MICROSCOPY TO GEOGRAPHIC PATHOLOGY. Exp Mol Pathol. 1965 Apr;28:189–204. doi: 10.1016/0014-4800(65)90032-8. [DOI] [PubMed] [Google Scholar]
  69. Saemundsen A. K., Berkel A. I., Henle W., Henle G., Anvret M., Sanal O., Ersoy F., Cağlar M., Klein G. Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia. Br Med J (Clin Res Ed) 1981 Feb 7;282(6262):425–427. doi: 10.1136/bmj.282.6262.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Shearer W. T., Ritz J., Finegold M. J., Guerra I. C., Rosenblatt H. M., Lewis D. E., Pollack M. S., Taber L. H., Sumaya C. V., Grumet F. C. Epstein-Barr virus-associated B-cell proliferations of diverse clonal origins after bone marrow transplantation in a 12-year-old patient with severe combined immunodeficiency. N Engl J Med. 1985 May 2;312(18):1151–1159. doi: 10.1056/NEJM198505023121804. [DOI] [PubMed] [Google Scholar]
  71. Sixbey J. W., Nedrud J. G., Raab-Traub N., Hanes R. A., Pagano J. S. Epstein-Barr virus replication in oropharyngeal epithelial cells. N Engl J Med. 1984 May 10;310(19):1225–1230. doi: 10.1056/NEJM198405103101905. [DOI] [PubMed] [Google Scholar]
  72. Sixbey J. W., Vesterinen E. H., Nedrud J. G., Raab-Traub N., Walton L. A., Pagano J. S. Replication of Epstein-Barr virus in human epithelial cells infected in vitro. Nature. 1983 Dec 1;306(5942):480–483. doi: 10.1038/306480a0. [DOI] [PubMed] [Google Scholar]
  73. Skare J. C., Milunsky A., Byron K. S., Sullivan J. L. Mapping the X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 1987 Apr;84(7):2015–2018. doi: 10.1073/pnas.84.7.2015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Spector B. D., Perry G. S., 3rd, Kersey J. H. Genetically determined immunodeficiency diseases (GDID) and malignancy: report from the immunodeficiency--cancer registry. Clin Immunol Immunopathol. 1978 Sep;11(1):12–29. doi: 10.1016/0090-1229(78)90200-3. [DOI] [PubMed] [Google Scholar]
  75. Straus S. E., Tosato G., Armstrong G., Lawley T., Preble O. T., Henle W., Davey R., Pearson G., Epstein J., Brus I. Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. Ann Intern Med. 1985 Jan;102(1):7–16. doi: 10.7326/0003-4819-102-1-7. [DOI] [PubMed] [Google Scholar]
  76. Sumaya C. V., Boswell R. N., Ench Y., Kisner D. L., Hersh E. M., Reuben J. M., Mansell P. W. Enhanced serological and virological findings of Epstein-Barr virus in patients with AIDS and AIDS-related complex. J Infect Dis. 1986 Nov;154(5):864–870. doi: 10.1093/infdis/154.5.864. [DOI] [PubMed] [Google Scholar]
  77. Sumaya C. V., Ench Y. Epstein-Barr virus infectious mononucleosis in children. II. Heterophil antibody and viral-specific responses. Pediatrics. 1985 Jun;75(6):1011–1019. [PubMed] [Google Scholar]
  78. Svedmyr E., Jondal M. Cytotoxic effector cells specific for B Cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis. Proc Natl Acad Sci U S A. 1975 Apr;72(4):1622–1626. doi: 10.1073/pnas.72.4.1622. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Thiele G., Bicak M., Grierson H., Lai P., Purtilo D. Antibody reactivity to a synthetic peptide (P62) of the Epstein-Barr nuclear antigen in sera of patients with X-linked lymphoproliferative syndrome. J Immunol Methods. 1987 Jun 26;100(1-2):249–259. doi: 10.1016/0022-1759(87)90196-7. [DOI] [PubMed] [Google Scholar]
  80. Thorley-Lawson D. A. The transformation of adult but not newborn human lymphocytes by Epstein Barr virus and phytohemagglutinin is inhibited by interferon: the early suppression by T cells of Epstein Barr infection is mediated by interferon. J Immunol. 1981 Mar;126(3):829–833. [PubMed] [Google Scholar]
  81. Tobi M., Straus S. E. Chronic Epstein-Barr virus disease: a workshop held by the National Institute of Allergy and Infectious Diseases. Ann Intern Med. 1985 Dec;103(6 ):951–953. doi: 10.7326/0003-4819-103-6-951. [DOI] [PubMed] [Google Scholar]
  82. Tosato G., Magrath I., Koski I., Dooley N., Blaese M. Activation of suppressor T cells during Epstein-Barr-virus-induced infectious mononucleosis. N Engl J Med. 1979 Nov 22;301(21):1133–1137. doi: 10.1056/NEJM197911223012101. [DOI] [PubMed] [Google Scholar]
  83. Zarling J. M., Eskra L., Borden E. C., Horoszewicz J., Carter W. A. Activation of human natural killer cells cytotoxic for human leukemia cells by purified interferon. J Immunol. 1979 Jul;123(1):63–70. [PubMed] [Google Scholar]
  84. Ziegler J. L. Burkitt's lymphoma. N Engl J Med. 1981 Sep 24;305(13):735–745. doi: 10.1056/NEJM198109243051305. [DOI] [PubMed] [Google Scholar]
  85. Zimber U., Adldinger H. K., Lenoir G. M., Vuillaume M., Knebel-Doeberitz M. V., Laux G., Desgranges C., Wittmann P., Freese U. K., Schneider U. Geographical prevalence of two types of Epstein-Barr virus. Virology. 1986 Oct 15;154(1):56–66. doi: 10.1016/0042-6822(86)90429-0. [DOI] [PubMed] [Google Scholar]
  86. zur Hausen H., Schulte-Holthausen H., Klein G., Henle W., Henle G., Clifford P., Santesson L. EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature. 1970 Dec 12;228(5276):1056–1058. doi: 10.1038/2281056a0. [DOI] [PubMed] [Google Scholar]

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