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. 1988 Oct;1(4):349–364. doi: 10.1128/cmr.1.4.349

Fungal infections of the immunocompromised host: clinical and laboratory aspects.

C E Musial 1, F R Cockerill 3rd 1, G D Roberts 1
PMCID: PMC358059  PMID: 3069198

Abstract

Fungal infections of the immunocompromised host are being seen with greater frequency than ever before. In addition, a growing list of unusual and unexpected etiologic agents presents a unique and difficult challenge to the clinician and microbiologist. The clinical manifestations of opportunistic fungal infections are often not characteristic and, in many instances, may prevent a rapid diagnosis from being made. Clinical microbiology laboratories should consider any organism as a potential etiologic agent. This requires that all fungi recovered from immunocompromised patients be thoroughly identified and reported so that their clinical significance may be assessed. This review presents a brief discussion of the clinical and laboratory aspects of some fungal infections seen in this important group of patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adam R. D., Paquin M. L., Petersen E. A., Saubolle M. A., Rinaldi M. G., Corcoran J. G., Galgiani J. N., Sobonya R. E. Phaeohyphomycosis caused by the fungal genera Bipolaris and Exserohilum. A report of 9 cases and review of the literature. Medicine (Baltimore) 1986 Jul;65(4):203–217. doi: 10.1097/00005792-198607000-00001. [DOI] [PubMed] [Google Scholar]
  2. Aisner J., Murillo J., Schimpff S. C., Steere A. C. Invasive aspergillosis in acute leukemia: correlation with nose cultures and antibiotic use. Ann Intern Med. 1979 Jan;90(1):4–9. doi: 10.7326/0003-4819-90-1-4. [DOI] [PubMed] [Google Scholar]
  3. Anaissie E., Kantarjian H., Jones P., Barlogie B., Luna M., Lopez-Berestein G., Bodey G. P. Fusarium. A newly recognized fungal pathogen in immunosuppressed patients. Cancer. 1986 Jun 1;57(11):2141–2145. doi: 10.1002/1097-0142(19860601)57:11<2141::aid-cncr2820571110>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  4. Anaissie E., Kantarjian H., Jones P. Fungal infection caused by Fusarium in cancer patients. Am J Clin Oncol. 1987 Feb;10(1):86–88. doi: 10.1097/00000421-198702000-00019. [DOI] [PubMed] [Google Scholar]
  5. Apaliski S. J., Moore M. D., Reiner B. J., Wald E. R. Disseminated Trichosporon beigelii in an immunocompromised child. Pediatr Infect Dis. 1984 Sep-Oct;3(5):451–454. doi: 10.1097/00006454-198409000-00016. [DOI] [PubMed] [Google Scholar]
  6. Arena F. P., Perlin M., Brahman H., Weiser B., Armstrong D. Fever, rash, and myalgias of dissseminated candidiasis during antifungal therapy. Arch Intern Med. 1981 Aug;141(9):1233–1233. [PubMed] [Google Scholar]
  7. Baird D. R., Harris M., Menon R., Stoddart R. W. Systemic infection with Trichosporon capitatum in two patients with acute leukaemia. Eur J Clin Microbiol. 1985 Feb;4(1):62–64. doi: 10.1007/BF02148664. [DOI] [PubMed] [Google Scholar]
  8. Baker J. G., Nadler H. L., Forgacs P., Kurtz S. R. Candida lusitaniae: a new opportunistic pathogen of the urinary tract. Diagn Microbiol Infect Dis. 1984 Apr;2(2):145–149. doi: 10.1016/0732-8893(84)90010-5. [DOI] [PubMed] [Google Scholar]
  9. Benbow E. W., McMahon R. F. Myocardial infarction caused by cardiac disease in disseminated zygomycosis. J Clin Pathol. 1987 Jan;40(1):70–74. doi: 10.1136/jcp.40.1.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bennett J. E., Dismukes W. E., Duma R. J., Medoff G., Sande M. A., Gallis H., Leonard J., Fields B. T., Bradshaw M., Haywood H. A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptoccal meningitis. N Engl J Med. 1979 Jul 19;301(3):126–131. doi: 10.1056/NEJM197907193010303. [DOI] [PubMed] [Google Scholar]
  11. Bhansali S., Karanes C., Palutke W., Crane L., Kiel R., Ratanatharathorn V. Successful treatment of disseminated Trichosporon beigelii (cutaneum) infection with associated splenic involvement. Cancer. 1986 Oct 15;58(8):1630–1632. doi: 10.1002/1097-0142(19861015)58:8<1630::aid-cncr2820580808>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  12. Bibler M. R., Luber H. J., Glueck H. I., Estes S. A. Disseminated sporotrichosis in a patient with HIV infection after treatment for acquired factor VIII inhibitor. JAMA. 1986 Dec 12;256(22):3125–3126. [PubMed] [Google Scholar]
  13. Bille J., Stockman L., Roberts G. D., Horstmeier C. D., Ilstrup D. M. Evaluation of a lysis-centrifugation system for recovery of yeasts and filamentous fungi from blood. J Clin Microbiol. 1983 Sep;18(3):469–471. doi: 10.1128/jcm.18.3.469-471.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Blazar B. R., Hurd D. D., Snover D. C., Alexander J. W., McGlave P. B. Invasive Fusarium infections in bone marrow transplant recipients. Am J Med. 1984 Oct;77(4):645–651. doi: 10.1016/0002-9343(84)90355-3. [DOI] [PubMed] [Google Scholar]
  15. Bonner J. R., Alexander W. J., Dismukes W. E., App W., Griffin F. M., Little R., Shin M. S. Disseminated histoplasmosis in patients with the acquired immune deficiency syndrome. Arch Intern Med. 1984 Nov;144(11):2178–2181. [PubMed] [Google Scholar]
  16. Bronnimann D. A., Adam R. D., Galgiani J. N., Habib M. P., Petersen E. A., Porter B., Bloom J. W. Coccidioidomycosis in the acquired immunodeficiency syndrome. Ann Intern Med. 1987 Mar;106(3):372–379. doi: 10.7326/0003-4819-106-3-372. [DOI] [PubMed] [Google Scholar]
  17. Brown E., Freedman S., Arbeit R., Come S. Invasive pulmonary aspergillosis in an apparently nonimmunocompromised host. Am J Med. 1980 Oct;69(4):624–627. doi: 10.1016/0002-9343(80)90478-7. [DOI] [PubMed] [Google Scholar]
  18. Byrne W. R., Wajszczuk C. P. Cryptococcal meningitis in the acquired immunodeficiency syndrome (AIDS): successful treatment with fluconazole after failure of amphotericin B. Ann Intern Med. 1988 Mar;108(3):384–385. doi: 10.7326/0003-4819-108-3-384. [DOI] [PubMed] [Google Scholar]
  19. Chaulk C. P., Smith R. W., Feagler J. R., Verdirame J., Commers J. R. Fungemia due to Fusarium solani in an immunocompromised child. Pediatr Infect Dis. 1986 May-Jun;5(3):363–366. doi: 10.1097/00006454-198605000-00017. [DOI] [PubMed] [Google Scholar]
  20. Cole S., Zawin M., Lundberg B., Hoffman J., Bailey L., Ernstoff M. S. Candida epiglottitis in an adult with acute nonlymphocytic leukemia. Am J Med. 1987 Mar 23;82(3 Spec No):662–664. doi: 10.1016/0002-9343(87)90119-7. [DOI] [PubMed] [Google Scholar]
  21. Coleman P. S., Gitter H. T., Talano J. V. Persistent fever in an immunocompromised host. Candida albicans endocarditis of the mitral valve. Arch Intern Med. 1986 Nov;146(11):2253–2255. [PubMed] [Google Scholar]
  22. Colman M. F. Epiglottitis in immunocompromised patients. Head Neck Surg. 1986 Jul-Aug;8(6):466–468. doi: 10.1002/hed.2890080612. [DOI] [PubMed] [Google Scholar]
  23. Davis W. A., Isner J. M., Bracey A. W., Roberts W. C., Garagusi V. F. Disseminated Petriellidium boydii and pacemaker endocarditis. Am J Med. 1980 Dec;69(6):929–932. doi: 10.1016/s0002-9343(80)80021-0. [DOI] [PubMed] [Google Scholar]
  24. Douer D., Goldschmied-Reouven A., Segev S., Ben-Bassat I. Human Exserohilum and Bipolaris infections: report of Exserohilum nasal infection in a neutropenic patient with acute leukemia and review of the literature. J Med Vet Mycol. 1987 Aug;25(4):235–241. [PubMed] [Google Scholar]
  25. Dupont B., Huber M., Kim S. J., Bennett J. E. Galactomannan antigenemia and antigenuria in aspergillosis: studies in patients and experimentally infected rabbits. J Infect Dis. 1987 Jan;155(1):1–11. doi: 10.1093/infdis/155.1.1. [DOI] [PubMed] [Google Scholar]
  26. Edson R. S., Fernandez-Guerrero M. L., Roberts G. D., Van Scoy R. E. Clinical and laboratory features of cryptococcosis. A five-year experience. Minn Med. 1987 Jun;70(6):337–342. [PubMed] [Google Scholar]
  27. Edwards J. E., Jr, Lehrer R. I., Stiehm E. R., Fischer T. J., Young L. S. Severe candidal infections: clinical perspective, immune defense mechanisms, and current concepts of therapy. Ann Intern Med. 1978 Jul;89(1):91–106. doi: 10.7326/0003-4819-89-1-91. [DOI] [PubMed] [Google Scholar]
  28. Edwards J. E., Turkel S. B., Elder H. A., Rand R. W., Guze L. B. Hematogenous candida osteomyelitis. Report of three cases and review of the literature. Am J Med. 1975 Jul;59(1):89–94. doi: 10.1016/0002-9343(75)90325-3. [DOI] [PubMed] [Google Scholar]
  29. Eng R. H., Bishburg E., Smith S. M., Kapila R. Cryptococcal infections in patients with acquired immune deficiency syndrome. Am J Med. 1986 Jul;81(1):19–23. doi: 10.1016/0002-9343(86)90176-2. [DOI] [PubMed] [Google Scholar]
  30. Enggano I. L., Hughes W. T., Kalwinsky D. K., Pearson T. A., Parham D. M., Stass S. A. Pseudallescheria boydii in a patient with acute lymphoblastic leukemia. Arch Pathol Lab Med. 1984 Aug;108(8):619–622. [PubMed] [Google Scholar]
  31. Fainstein V., Gilmore C., Hopfer R. L., Maksymiuk A., Bodey G. P. Septic arthritis due to Candida species on patients with cancer: report of five cases and review of the literature. Rev Infect Dis. 1982 Jan-Feb;4(1):78–85. doi: 10.1093/clinids/4.1.78. [DOI] [PubMed] [Google Scholar]
  32. Farman J., Tavitian A., Rosenthal L. E., Schwartz G. E., Raufman J. P. Focal esophageal candidiasis in acquired immunodeficiency syndrome (AIDS). Gastrointest Radiol. 1986;11(3):213–217. doi: 10.1007/BF02035076. [DOI] [PubMed] [Google Scholar]
  33. Fleischmann J., Church J. A., Lehrer R. I. Primary Candida meningitis and chronic granulomatous disease. Am J Med Sci. 1986 May;291(5):334–341. doi: 10.1097/00000441-198605000-00009. [DOI] [PubMed] [Google Scholar]
  34. Franklin W. G., Simon A. B., Sodeman T. M. Candida myocarditis without valvulitis. Am J Cardiol. 1976 Dec;38(7):924–928. doi: 10.1016/0002-9149(76)90805-5. [DOI] [PubMed] [Google Scholar]
  35. Frenkel L., Kuhls T. L., Nitta K., Clancy M., Howard D. H., Ward P., Cherry J. D. Recurrent Bipolaris sinusitis following surgical and antifungal therapy. Pediatr Infect Dis J. 1987 Dec;6(12):1130–1132. [PubMed] [Google Scholar]
  36. Funada H., Misawa T., Nakao S., Saga T., Hattori K. I. The air crescent sign of invasive pulmonary mucormycosis in acute leukemia. Cancer. 1984 Jun 15;53(12):2721–2723. doi: 10.1002/1097-0142(19840615)53:12<2721::aid-cncr2820531228>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  37. Fung J. C., Donta S. T., Tilton R. C. Candida detection system (CAND-TEC) to differentiate between Candida albicans colonization and disease. J Clin Microbiol. 1986 Oct;24(4):542–547. doi: 10.1128/jcm.24.4.542-547.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Gal A. A., Koss M. N., Hawkins J., Evans S., Einstein H. The pathology of pulmonary cryptococcal infections in the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1986 Jun;110(6):502–507. [PubMed] [Google Scholar]
  39. Galgiani J. N., Stevens D. A., Graybill J. R., Stevens D. L., Tillinghast A. J., Levine H. B. Pseudallescheria boydii infections treated with ketoconazole. Clinical evaluations of seven patients and in vitro susceptibility results. Chest. 1984 Aug;86(2):219–224. doi: 10.1378/chest.86.2.219. [DOI] [PubMed] [Google Scholar]
  40. Geisler C., Ernst P., Vejlsgaard R. Candida Pericarditis in a patients with leukaemia. Scand J Haematol. 1981 Aug;27(2):75–78. doi: 10.1111/j.1600-0609.1981.tb00455.x. [DOI] [PubMed] [Google Scholar]
  41. Gerson S. L., Talbot G. H., Hurwitz S., Strom B. L., Lusk E. J., Cassileth P. A. Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med. 1984 Mar;100(3):345–351. doi: 10.7326/0003-4819-100-3-345. [DOI] [PubMed] [Google Scholar]
  42. Gluckman S. J., Ries K., Abrutyn E. Allescheria (Petriellidium) boydii sinusitis in a compromised host. J Clin Microbiol. 1977 Apr;5(4):481–484. doi: 10.1128/jcm.5.4.481-484.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Gold J. W., Poston W., Mertelsmann R., Lange M., Kiehn T., Edwards F., Bernard E., Christiansen K., Armstrong D. Systemic infection with Trichosporon cutaneum in a patient with acute leukemia: report of a case. Cancer. 1981 Nov 15;48(10):2163–2167. doi: 10.1002/1097-0142(19811115)48:10<2163::aid-cncr2820481008>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  44. Gold J. W., Wong B., Bernard E. M., Kiehn T. E., Armstrong D. Serum arabinitol concentrations and arabinitol/creatinine ratios in invasive candidiasis. J Infect Dis. 1983 Mar;147(3):504–513. doi: 10.1093/infdis/147.3.504. [DOI] [PubMed] [Google Scholar]
  45. Grossman M. E., Fithian E. C., Behrens C., Bissinger J., Fracaro M., Neu H. C. Primary cutaneous aspergillosis in six leukemic children. J Am Acad Dermatol. 1985 Feb;12(2 Pt 1):313–318. doi: 10.1016/s0190-9622(85)80042-6. [DOI] [PubMed] [Google Scholar]
  46. Guerra-Romero L., Edson R. S., Cockerill F. R., 3rd, Horstmeier C. D., Roberts G. D. Comparison of Du Pont Isolator and Roche Septi-Chek for detection of fungemia. J Clin Microbiol. 1987 Sep;25(9):1623–1625. doi: 10.1128/jcm.25.9.1623-1625.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Guice K. S., Lynch M., Weatherbee L. Invasive aspergillosis: an unusual cause of hemorrhagic pancreatitis. Am J Gastroenterol. 1987 Jun;82(6):563–565. [PubMed] [Google Scholar]
  48. Haron E., Feld R., Tuffnell P., Patterson B., Hasselback R., Matlow A. Hepatic candidiasis: an increasing problem in immunocompromised patients. Am J Med. 1987 Jul;83(1):17–26. doi: 10.1016/0002-9343(87)90492-x. [DOI] [PubMed] [Google Scholar]
  49. Haupt H. M., Merz W. G., Beschorner W. E., Vaughan W. P., Saral R. Colonization and infection with Trichosporon species in the immunosuppressed host. J Infect Dis. 1983 Feb;147(2):199–203. doi: 10.1093/infdis/147.2.199. [DOI] [PubMed] [Google Scholar]
  50. Hecht R., Montgomerie J. Z. Maxillary sinus infection with Allescheria boydii (Petriellidium boydii). Johns Hopkins Med J. 1978 Apr;142(4):107–109. [PubMed] [Google Scholar]
  51. Henochowicz S., Mustafa M., Lawrinson W. E., Pistole M., Lindsay J., Jr Cardiac aspergillosis in acquired immune deficiency syndrome. Am J Cardiol. 1985 Apr 15;55(9):1239–1240. doi: 10.1016/0002-9149(85)90679-4. [DOI] [PubMed] [Google Scholar]
  52. Hoppin E. C., McCoy E. L., Rinaldi M. G. Opportunistic mycotic infection caused by Chaetomium in a patient with acute leukemia. Cancer. 1983 Aug 1;52(3):555–556. doi: 10.1002/1097-0142(19830801)52:3<555::aid-cncr2820520328>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  53. Hoy J., Hsu K. C., Rolston K., Hopfer R. L., Luna M., Bodey G. P. Trichosporon beigelii infection: a review. Rev Infect Dis. 1986 Nov-Dec;8(6):959–967. [PubMed] [Google Scholar]
  54. Iqbal S. M., Scheer R. L. Myocardial mucormycosis with emboli in a hemodialysis patient. Am J Kidney Dis. 1986 Dec;8(6):455–458. doi: 10.1016/s0272-6386(86)80175-5. [DOI] [PubMed] [Google Scholar]
  55. Jade K. B., Lyons M. F., Gnann J. W., Jr Paecilomyces lilacinus cellulitis in an immunocompromised patient. Arch Dermatol. 1986 Oct;122(10):1169–1170. [PubMed] [Google Scholar]
  56. Jones J. M. Granulomatous hepatitis due to Candida albicans in patients with acute leukemia. Ann Intern Med. 1981 Apr;94(4 Pt 1):475–477. doi: 10.7326/0003-4819-94-4-475. [DOI] [PubMed] [Google Scholar]
  57. June C. H., Beatty P. G., Shulman H. M., Rinaldi M. G. Disseminated Fusarium moniliforme infection after allogeneic marrow transplantation. South Med J. 1986 Apr;79(4):513–515. doi: 10.1097/00007611-198604000-00032. [DOI] [PubMed] [Google Scholar]
  58. Kaczmarski E. B., Liu Yin J. A., Tooth J. A., Love E. M., Delamore I. W. Systemic infection with Aureobasidium pullulans in a leukaemic patient. J Infect. 1986 Nov;13(3):289–291. doi: 10.1016/s0163-4453(86)91388-5. [DOI] [PubMed] [Google Scholar]
  59. Kahn F. W., Jones J. M. Latex agglutination tests for detection of Candida antigens in sera of patients with invasive candidiasis. J Infect Dis. 1986 Mar;153(3):579–585. doi: 10.1093/infdis/153.3.579. [DOI] [PubMed] [Google Scholar]
  60. Kassamali H., Anaissie E., Ro J., Rolston K., Kantarjian H., Fainstein V., Bodey G. P. Disseminated Geotrichum candidum infection. J Clin Microbiol. 1987 Sep;25(9):1782–1783. doi: 10.1128/jcm.25.9.1782-1783.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Kerridge D., Nicholas R. O. Drug resistance in the opportunistic pathogens Candida albicans and Candida glabrata. J Antimicrob Chemother. 1986 Oct;18 (Suppl B):39–49. doi: 10.1093/jac/18.supplement_b.39. [DOI] [PubMed] [Google Scholar]
  62. Klein R. S., Harris C. A., Small C. B., Moll B., Lesser M., Friedland G. H. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med. 1984 Aug 9;311(6):354–358. doi: 10.1056/NEJM198408093110602. [DOI] [PubMed] [Google Scholar]
  63. Kobayashi M., Matsuoka T., Taguchi H., Moriki T., Enzan H., Hara H., Miyoshi I. Trichosporon beigelii pneumonia in a patient with malignant histiocytosis. Jpn J Clin Oncol. 1986 Jun;16(2):167–174. doi: 10.1093/oxfordjournals.jjco.a039134. [DOI] [PubMed] [Google Scholar]
  64. Korinek J. K., Guarda L. A., Bolivar R., Stroehlein J. R. Trichosporon hepatitis. Gastroenterology. 1983 Sep;85(3):732–734. [PubMed] [Google Scholar]
  65. Kovacs J. A., Kovacs A. A., Polis M., Wright W. C., Gill V. J., Tuazon C. U., Gelmann E. P., Lane H. C., Longfield R., Overturf G. Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med. 1985 Oct;103(4):533–538. doi: 10.7326/0003-4819-103-4-533. [DOI] [PubMed] [Google Scholar]
  66. Kuhlman J. E., Fishman E. K., Siegelman S. S. Invasive pulmonary aspergillosis in acute leukemia: characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis. Radiology. 1985 Dec;157(3):611–614. doi: 10.1148/radiology.157.3.3864189. [DOI] [PubMed] [Google Scholar]
  67. Lentino J. R., Rosenkranz M. A., Michaels J. A., Kurup V. P., Rose H. D., Rytel M. W. Nosocomial aspergillosis: a retrospective review of airborne disease secondary to road construction and contaminated air conditioners. Am J Epidemiol. 1982 Sep;116(3):430–437. doi: 10.1093/oxfordjournals.aje.a113427. [DOI] [PubMed] [Google Scholar]
  68. Levy S. A., Schmitt K. W., Kaufman L. Systemic zygomycosis diagnosed by fine needle aspiration and confirmed with enzyme immunoassay. Chest. 1986 Jul;90(1):146–148. doi: 10.1378/chest.90.1.146. [DOI] [PubMed] [Google Scholar]
  69. Lewis W., Lipsick J., Cammarosano C. Cryptococcal myocarditis in acquired immune deficiency syndrome. Am J Cardiol. 1985 Apr 15;55(9):1240–1240. doi: 10.1016/0002-9149(85)90680-0. [DOI] [PubMed] [Google Scholar]
  70. Libertin C. R., Davies N. J., Halper J., Edson R. S., Roberts G. D. Invasive disease caused by Trichosporon beigelii. Mayo Clin Proc. 1983 Oct;58(10):684–686. [PubMed] [Google Scholar]
  71. Libertin C. R., Wilson W. R., Roberts G. D. Candida lusitaniae--an opportunistic pathogen. Diagn Microbiol Infect Dis. 1985 Jan;3(1):69–71. doi: 10.1016/0732-8893(85)90069-0. [DOI] [PubMed] [Google Scholar]
  72. Lief M., Sarfarazi F. Prostatic cryptococcosis in acquired immune deficiency syndrome. Urology. 1986 Oct;28(4):318–319. doi: 10.1016/0090-4295(86)90016-6. [DOI] [PubMed] [Google Scholar]
  73. Loveless M. O., Winn R. E., Campbell M., Jones S. R. Mixed invasive infection with Alternaria species and Curvularia species. Am J Clin Pathol. 1981 Oct;76(4):491–493. doi: 10.1093/ajcp/76.4.491. [DOI] [PubMed] [Google Scholar]
  74. Lutwick L. I., Rytel M. W., Yañez J. P., Galgiani J. N., Stevens D. A. Deep infections from Petriellidium boydii treated with miconazole. JAMA. 1979 Jan 19;241(3):272–273. [PubMed] [Google Scholar]
  75. Manabe T., Moriya T., Shirabe T., Takemoto Y. Disseminated Trichosporon beigelii infection in a patient with malignant histiocytosis. Acta Pathol Jpn. 1986 Aug;36(8):1241–1250. doi: 10.1111/j.1440-1827.1986.tb02845.x. [DOI] [PubMed] [Google Scholar]
  76. Mandell W., Goldberg D. M., Neu H. C. Histoplasmosis in patients with the acquired immune deficiency syndrome. Am J Med. 1986 Dec;81(6):974–978. doi: 10.1016/0002-9343(86)90390-6. [DOI] [PubMed] [Google Scholar]
  77. Masur H., Rosen P. P., Armstrong D. Pulmonary disease caused by Candida species. Am J Med. 1977 Dec;63(6):914–925. doi: 10.1016/0002-9343(77)90546-0. [DOI] [PubMed] [Google Scholar]
  78. Matsuda T., Matsumoto T. Disseminated hyalohyphomycosis in a leukemic patient. Arch Dermatol. 1986 Oct;122(10):1171–1175. [PubMed] [Google Scholar]
  79. McAleer R., Kroenert D. B., Elder J. L., Froudist J. H. Allergic bronchopulmonary disease caused by Curvularia lunata and Drechslera hawaiiensis. Thorax. 1981 May;36(5):338–344. doi: 10.1136/thx.36.5.338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. McManus E. J., Bozdech M. J., Jones J. M. Role of the latex agglutination test for cryptococcal antigen in diagnosing disseminated infections with Trichosporon beigelii. J Infect Dis. 1985 Jun;151(6):1167–1169. doi: 10.1093/infdis/151.6.1167. [DOI] [PubMed] [Google Scholar]
  81. McManus E. J., Jones J. M. Detection of a Trichosporon beigelii antigen cross-reactive with Cryptococcus neoformans capsular polysaccharide in serum from a patient with disseminated Trichosporon infection. J Clin Microbiol. 1985 May;21(5):681–685. doi: 10.1128/jcm.21.5.681-685.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Morgan M. A., Wilkowske C. J., Roberts G. D. Candida pseudotropicalis fungemia and invasive disease in an immunocompromised patient. J Clin Microbiol. 1984 Nov;20(5):1006–1007. doi: 10.1128/jcm.20.5.1006-1007.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Murata K., Sekigawa T., Sakamoto T., Yamazaki T., Torizuka K. Opportunistic esophagitis caused by Aspergillus fumigatus. Radiat Med. 1984 Jan-Mar;2(1):24–26. [PubMed] [Google Scholar]
  84. Mutton K. J., Lucas T. J., Harkness J. L. Disseminated fusarium infection. Med J Aust. 1980 Nov 29;2(11):624–625. doi: 10.5694/j.1326-5377.1980.tb77068.x. [DOI] [PubMed] [Google Scholar]
  85. Oelz O., Schaffner A., Frick P., Schaer G. Trichosporon capitatum: thrush-like oral infection, local invasion, fungaemia and metastatic abscess formation in a leukaemic patient. J Infect. 1983 Mar;6(2):183–185. doi: 10.1016/s0163-4453(83)92942-0. [DOI] [PubMed] [Google Scholar]
  86. Parra R., Arnau E., Julia A., Lopez A., Nadal A., Allende E. Survival after intestinal mucormycosis in acute myelogenous leukemia. Cancer. 1986 Dec 15;58(12):2717–2719. doi: 10.1002/1097-0142(19861215)58:12<2717::aid-cncr2820581227>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  87. Reinhart H. H., Urbanski D. M., Harrington S. D., Sobel J. D. Prosthetic valve endocarditis caused by Trichosporon beigelii. Am J Med. 1988 Feb;84(2):355–358. doi: 10.1016/0002-9343(88)90440-8. [DOI] [PubMed] [Google Scholar]
  88. Rhoads J. L., Wright D. C., Redfield R. R., Burke D. S. Chronic vaginal candidiasis in women with human immunodeficiency virus infection. JAMA. 1987 Jun 12;257(22):3105–3107. [PubMed] [Google Scholar]
  89. Ricciardi D. D., Sepkowitz D. V., Berkowitz L. B., Bienenstock H., Maslow M. Cryptococcal arthritis in a patient with acquired immune deficiency syndrome. Case report and review of the literature. J Rheumatol. 1986 Apr;13(2):455–458. [PubMed] [Google Scholar]
  90. Rico M. J., Penneys N. S. Cutaneous cryptococcosis resembling molluscum contagiosum in a patient with AIDS. Arch Dermatol. 1985 Jul;121(7):901–902. [PubMed] [Google Scholar]
  91. Rolston K. V., Hopfer R. L., Larson D. L. Infections caused by Drechslera species: case report and review of the literature. Rev Infect Dis. 1985 Jul-Aug;7(4):525–529. doi: 10.1093/clinids/7.4.525. [DOI] [PubMed] [Google Scholar]
  92. Rosenberg S. W., Lepley J. B. Mucormycosis in leukemia. Oral Surg Oral Med Oral Pathol. 1982 Jul;54(1):26–32. doi: 10.1016/0030-4220(82)90413-3. [DOI] [PubMed] [Google Scholar]
  93. Rosenblatt H. M., Stiehm E. R. Therapy of chronic mucocutaneous candidiasis. Am J Med. 1983 Jan 24;74(1B):20–22. doi: 10.1016/0002-9343(83)90510-7. [DOI] [PubMed] [Google Scholar]
  94. Rotterdam H. Tissue diagnosis of selected AIDS-related opportunistic infections. Am J Surg Pathol. 1987;11 (Suppl 1):3–15. doi: 10.1097/00000478-198700111-00001. [DOI] [PubMed] [Google Scholar]
  95. Rusthoven J. J., Feld R., Tuffnell P. G. Systemic infection by Rhodotorula spp. in the immunocompromised host. J Infect. 1984 May;8(3):241–246. doi: 10.1016/s0163-4453(84)93979-3. [DOI] [PubMed] [Google Scholar]
  96. Sabetta J. R., Miniter P., Andriole V. T. The diagnosis of invasive aspergillosis by an enzyme-linked immunosorbent assay for circulating antigen. J Infect Dis. 1985 Nov;152(5):946–953. doi: 10.1093/infdis/152.5.946. [DOI] [PubMed] [Google Scholar]
  97. Salkin I. F., Martinez J. A., Kemna M. E. Opportunistic infection of the spleen caused by Aureobasidium pullulans. J Clin Microbiol. 1986 May;23(5):828–831. doi: 10.1128/jcm.23.5.828-831.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Sarubbi F. A., Jr, Kopf H. B., Wilson M. B., McGinnis M. R., Rutala W. A. Increased recovery of Aspergillus flavus from respiratory specimens during hospital construction. Am Rev Respir Dis. 1982 Jan;125(1):33–38. doi: 10.1164/arrd.1982.125.1.33. [DOI] [PubMed] [Google Scholar]
  99. Saul S. H., Khachatoorian T., Poorsattar A., Myerowitz R. L., Geyer S. J., Pasculle A. W., Ho M. Opportunistic Trichosporon pneumonia. Association with invasive aspergillosis. Arch Pathol Lab Med. 1981 Sep;105(9):456–459. [PubMed] [Google Scholar]
  100. Shaikh B. S., Appelbaum P. C., Aber R. C. Vertebral disc space infection and osteomyelitis due to Candida albicans in a patient with acute myelomonocytic leukemia. Cancer. 1980 Mar 1;45(5):1025–1028. doi: 10.1002/1097-0142(19800301)45:5<1025::aid-cncr2820450532>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  101. Shih L. Y., Lee N. Disseminated petriellidiosis (allescheriasis) in a patient with refractory acute lymphoblastic leukaemia. J Clin Pathol. 1984 Jan;37(1):78–82. doi: 10.1136/jcp.37.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Slevin M. L., Knowles G. K., Phillips M. J., Stansfeld A. G., Lister T. A. The air crescent sign of invasive pulmonary aspergillosis in acute leukaemia. Thorax. 1982 Jul;37(7):554–555. doi: 10.1136/thx.37.7.554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  103. Smego R. A., Jr, Devoe P. W., Sampson H. A., Perfect J. R., Wilfert C. M., Buckley R. H. Candida meningitis in two children with severe combined immunodeficiency. J Pediatr. 1984 Jun;104(6):902–904. doi: 10.1016/s0022-3476(84)80493-x. [DOI] [PubMed] [Google Scholar]
  104. Smith A. G., Crain S. M., Dejongh C., Thomas G. M., Vigorito R. D. Systemic pseudallescheriasis in a patient with acute myelocytic leukemia. Mycopathologia. 1985 May;90(2):85–89. doi: 10.1007/BF00436855. [DOI] [PubMed] [Google Scholar]
  105. So S. Y., Chau P. Y., Jones B. M., Wu P. C., Pun K. K., Lam W. K., Lawton J. W. A case of invasive penicilliosis in Hong Kong with immunologic evaluation. Am Rev Respir Dis. 1985 Apr;131(4):662–665. doi: 10.1164/arrd.1985.131.4.662. [DOI] [PubMed] [Google Scholar]
  106. Sobel J. D. Recurrent vulvovaginal candidiasis. A prospective study of the efficacy of maintenance ketoconazole therapy. N Engl J Med. 1986 Dec 4;315(23):1455–1458. doi: 10.1056/NEJM198612043152305. [DOI] [PubMed] [Google Scholar]
  107. Spearing R. L., Pamphilon D. H., Prentice A. G. Pulmonary aspergillosis in immunosuppressed patients with haematological malignancies. Q J Med. 1986 Jun;59(230):611–625. [PubMed] [Google Scholar]
  108. St-Germain G., Laverdière M. Torulopsis candida, a new opportunistic pathogen. J Clin Microbiol. 1986 Nov;24(5):884–885. doi: 10.1128/jcm.24.5.884-885.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Stockman L., Roberts G. D. Specificity of the latex test for cryptococcal antigen: a rapid, simple method for eliminating interference factors. J Clin Microbiol. 1982 Nov;16(5):965–967. doi: 10.1128/jcm.16.5.965-967.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  110. Sugar A. M., Restrepo A., Stevens D. A. Paracoccidioidomycosis in the immunosuppressed host: report of a case and review of the literature. Am Rev Respir Dis. 1984 Feb;129(2):340–342. [PubMed] [Google Scholar]
  111. Sugar A. M., Stevens D. A. Candida rugosa in immunocompromised infection. Case reports, drug susceptibility, and review of the literature. Cancer. 1985 Jul 15;56(2):318–320. doi: 10.1002/1097-0142(19850715)56:2<318::aid-cncr2820560219>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  112. Summerbell R. C., Richardson S. E., Kane J. Fusarium proliferatum as an agent of disseminated infection in an immunosuppressed patient. J Clin Microbiol. 1988 Jan;26(1):82–87. doi: 10.1128/jcm.26.1.82-87.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  113. Talbot G. H., Weiner M. H., Gerson S. L., Provencher M., Hurwitz S. Serodiagnosis of invasive aspergillosis in patients with hematologic malignancy: validation of the Aspergillus fumigatus antigen radioimmunoassay. J Infect Dis. 1987 Jan;155(1):12–27. doi: 10.1093/infdis/155.1.12. [DOI] [PubMed] [Google Scholar]
  114. Tashjian L. S., Abramson J. S., Peacock J. E., Jr Focal hepatic candidiasis: a distinct clinical variant of candidiasis in immunocompromised patients. Rev Infect Dis. 1984 Sep-Oct;6(5):689–703. doi: 10.1093/clinids/6.5.689. [DOI] [PubMed] [Google Scholar]
  115. Tavitian A., Raufman J. P., Rosenthal L. E. Oral candidiasis as a marker for esophageal candidiasis in the acquired immunodeficiency syndrome. Ann Intern Med. 1986 Jan;104(1):54–55. doi: 10.7326/0003-4819-104-1-54. [DOI] [PubMed] [Google Scholar]
  116. Tavitian A., Raufman J. P., Rosenthal L. E., Weber J., Webber C. A., Dincsoy H. P. Ketoconazole-resistant Candida esophagitis in patients with acquired immunodeficiency syndrome. Gastroenterology. 1986 Feb;90(2):443–445. doi: 10.1016/0016-5085(86)90946-7. [DOI] [PubMed] [Google Scholar]
  117. Terreni A. A., Strohecker J. S., Dowda H., Jr Candida lusitaniae septicemia in a patient on extended home intravenous hyperalimentation. J Med Vet Mycol. 1987 Feb;25(1):63–65. doi: 10.1080/02681218780000091. [DOI] [PubMed] [Google Scholar]
  118. Torres-Rojas J. R., Stratton C. W., Sanders C. V., Horsman T. A., Hawley H. B., Dascomb H. E., Vial L. J., Jr Candidal suppurative peripheral thrombophlebitis. Ann Intern Med. 1982 Apr;96(4):431–435. doi: 10.7326/0003-4819-96-4-431. [DOI] [PubMed] [Google Scholar]
  119. Travis L. B., Roberts G. D., Wilson W. R. Clinical significance of Pseudallescheria boydii: a review of 10 years' experience. Mayo Clin Proc. 1985 Aug;60(8):531–537. doi: 10.1016/s0025-6196(12)60571-0. [DOI] [PubMed] [Google Scholar]
  120. Treger T. R., Visscher D. W., Bartlett M. S., Smith J. W. Diagnosis of pulmonary infection caused by Aspergillus: usefulness of respiratory cultures. J Infect Dis. 1985 Sep;152(3):572–576. doi: 10.1093/infdis/152.3.572. [DOI] [PubMed] [Google Scholar]
  121. Veglia K. S., Marks V. J. Fusarium as a pathogen. A case report of Fusarium sepsis and review of the literature. J Am Acad Dermatol. 1987 Jan;16(1 Pt 2):260–263. [PubMed] [Google Scholar]
  122. Ventura G. J., Kantarjian H. M., Anaissie E., Hopfer R. L., Fainstein V. Pneumonia with Cunninghamella species in patients with hematologic malignancies. A case report and review of the literature. Cancer. 1986 Oct 1;58(7):1534–1536. doi: 10.1002/1097-0142(19861001)58:7<1534::aid-cncr2820580725>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  123. Viollier A. F., Peterson D. E., De Jongh C. A., Newman K. A., Gray W. C., Sutherland J. C., Moody M. A., Schimpff S. C. Aspergillus sinusitis in cancer patients. Cancer. 1986 Jul 15;58(2):366–371. doi: 10.1002/1097-0142(19860715)58:2<366::aid-cncr2820580228>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  124. Viviani M. A., Tortorano A. M., Laria G., Giannetti A., Bignotti G. Two new cases of cutaneous alternariosis with a review of the literature. Mycopathologia. 1986 Oct;96(1):3–12. doi: 10.1007/BF00467678. [DOI] [PubMed] [Google Scholar]
  125. Walling D. M., McGraw D. J., Merz W. G., Karp J. E., Hutchins G. M. Disseminated infection with Trichosporon beigelii. Rev Infect Dis. 1987 Sep-Oct;9(5):1013–1019. doi: 10.1093/clinids/9.5.1013. [DOI] [PubMed] [Google Scholar]
  126. Walsh T. J., Bulkley B. H. Aspergillus pericarditis: clinical and pathologic features in the immunocompromised patient. Cancer. 1982 Jan 1;49(1):48–54. doi: 10.1002/1097-0142(19820101)49:1<48::aid-cncr2820490112>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  127. Walsh T. J., Gray W. C. Candida epiglottitis in immunocompromised patients. Chest. 1987 Apr;91(4):482–485. doi: 10.1378/chest.91.4.482. [DOI] [PubMed] [Google Scholar]
  128. Walsh T. J., Newman K. R., Moody M., Wharton R. C., Wade J. C. Trichosporonosis in patients with neoplastic disease. Medicine (Baltimore) 1986 Jul;65(4):268–279. doi: 10.1097/00005792-198607000-00005. [DOI] [PubMed] [Google Scholar]
  129. Weems J. J., Jr, Davis B. J., Tablan O. C., Kaufman L., Martone W. J. Construction activity: an independent risk factor for invasive aspergillosis and zygomycosis in patients with hematologic malignancy. Infect Control. 1987 Feb;8(2):71–75. doi: 10.1017/s0195941700067114. [DOI] [PubMed] [Google Scholar]
  130. Weingrad D. N., Knapper W. H., Gold J., Mertelsmann R. Aspergillus Peritonitis complicating perforated appendicitis in adult acute leukemia. J Surg Oncol. 1982 Jan;19(1):5–8. doi: 10.1002/jso.2930190103. [DOI] [PubMed] [Google Scholar]
  131. Wheat L. J., Slama T. G., Zeckel M. L. Histoplasmosis in the acquired immune deficiency syndrome. Am J Med. 1985 Feb;78(2):203–210. doi: 10.1016/0002-9343(85)90427-9. [DOI] [PubMed] [Google Scholar]
  132. Wheat L. J., Small C. B. Disseminated histoplasmosis in the acquired immune deficiency syndrome. Arch Intern Med. 1984 Nov;144(11):2147–2149. [PubMed] [Google Scholar]
  133. Yohn J. J., Lucas J., Camisa C. Malassezia folliculitis in immunocompromised patients. Cutis. 1985 Jun;35(6):536–538. [PubMed] [Google Scholar]
  134. Yoo D., Lee W. H., Kwon-Chung K. J. Brain abscesses due to Pseudallescheria boydii associated with primary non-Hodgkin's lymphoma of the central nervous system: a case report and literature review. Rev Infect Dis. 1985 Mar-Apr;7(2):272–277. doi: 10.1093/clinids/7.2.272. [DOI] [PubMed] [Google Scholar]
  135. Young R. C., Bennett J. E., Vogel C. L., Carbone P. P., DeVita V. T. Aspergillosis. The spectrum of the disease in 98 patients. Medicine (Baltimore) 1970 Mar;49(2):147–173. doi: 10.1097/00005792-197003000-00002. [DOI] [PubMed] [Google Scholar]
  136. Yung C. W., Hanauer S. B., Fretzin D., Rippon J. W., Shapiro C., Gonzalez M. Disseminated Trichosporon beigelii (cutaneum). Cancer. 1981 Nov 1;48(9):2107–2111. doi: 10.1002/1097-0142(19811101)48:9<2107::aid-cncr2820480932>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  137. Zach T. L., Penn R. G., Gnarra D. J., Bever J. L. Fusarium moniliforme pneumonia. Nebr Med J. 1987 Jan;72(1):6–9. [PubMed] [Google Scholar]
  138. Zackheim H. S., Halde C., Goodman R. S., Marchasin S., Buncke H. J., Jr Phaeohyphomycotic cyst of the skin caused by Exophiala jeanselmei. J Am Acad Dermatol. 1985 Jan;12(1 Pt 2):207–212. doi: 10.1016/s0190-9622(85)80019-0. [DOI] [PubMed] [Google Scholar]
  139. Zuger A., Louie E., Holzman R. S., Simberkoff M. S., Rahal J. J. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment. Ann Intern Med. 1986 Feb;104(2):234–240. doi: 10.7326/0003-4819-104-2-234. [DOI] [PubMed] [Google Scholar]
  140. de Repentigny L., Reiss E. Current trends in immunodiagnosis of candidiasis and aspergillosis. Rev Infect Dis. 1984 May-Jun;6(3):301–312. doi: 10.1093/clinids/6.3.301. [DOI] [PubMed] [Google Scholar]

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