Skip to main content
Clinical Microbiology Reviews logoLink to Clinical Microbiology Reviews
. 1989 Apr;2(Suppl):S125–S133. doi: 10.1128/cmr.2.suppl.s125

Beta-lactamase plasmids and chromosomally mediated antibiotic resistance in pathogenic Neisseria species.

J A Dillon 1, K H Yeung 1
PMCID: PMC358089  PMID: 2655882

Full text

PDF
S125

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aalen R. B., Gundersen W. B. Molecular characterization and comparison of plasmid content in seven different strains of Neisseria gonorrhoeae. Acta Pathol Microbiol Immunol Scand B. 1987 Feb;95(1):13–21. doi: 10.1111/j.1699-0463.1987.tb03081.x. [DOI] [PubMed] [Google Scholar]
  2. Ansink-Schiper M. C., van Embden J. D., van Klingeren B., Woudstra R. Further spread of plasmids among different auxotypes of penicillinase-producing gonococci. Lancet. 1982 Feb 20;1(8269):445–445. doi: 10.1016/s0140-6736(82)91640-3. [DOI] [PubMed] [Google Scholar]
  3. Ashford W. A., Golash R. G., Hemming V. G. Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976 Sep 25;2(7987):657–658. doi: 10.1016/s0140-6736(76)92467-3. [DOI] [PubMed] [Google Scholar]
  4. Band J. D., Chamberland M. E., Platt T., Weaver R. E., Thornsberry C., Fraser D. W. Trends in meningococcal disease in the United States, 1975-1980. J Infect Dis. 1983 Oct;148(4):754–758. doi: 10.1093/infdis/148.4.754. [DOI] [PubMed] [Google Scholar]
  5. Bezanson G. S., Pauzé M., Lior H. Antibiotic resistance and R-plasmids in food chain Salmonella: evidence of plasmid relatedness. Appl Environ Microbiol. 1981 Mar;41(3):585–592. doi: 10.1128/aem.41.3.585-592.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Botha P. Penicillin-resistant Neisseria meningitidis in southern Africa. Lancet. 1988 Jan 2;1(8575-6):54–54. doi: 10.1016/s0140-6736(88)91029-x. [DOI] [PubMed] [Google Scholar]
  7. Brunton J., Clare D., Meier M. A. Molecular epidemiology of antibiotic resistance plasmids of Haemophilus species and Neisseria gonorrhoeae. Rev Infect Dis. 1986 Sep-Oct;8(5):713–724. doi: 10.1093/clinids/8.5.713. [DOI] [PubMed] [Google Scholar]
  8. Brunton J., Meier M., Ehrman N., Maclean I., Slaney L., Albritton W. L. Molecular epidemiology of beta-lactamase-specifying plasmids of Haemophilus ducreyi. Antimicrob Agents Chemother. 1982 Jun;21(6):857–863. doi: 10.1128/aac.21.6.857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Brunton J., Meier M., Erhman N., Clare D., Almawy R. Origin of small beta-lactamase-specifying plasmids in Haemophilus species and Neisseria gonorrhoeae. J Bacteriol. 1986 Oct;168(1):374–379. doi: 10.1128/jb.168.1.374-379.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cannon J. G., Sparling P. F. The genetics of the gonococcus. Annu Rev Microbiol. 1984;38:111–133. doi: 10.1146/annurev.mi.38.100184.000551. [DOI] [PubMed] [Google Scholar]
  11. Catlin B. W., Reyn A. Neisseria gonorrhoeae isolated from disseminated and localised infections in pre-penicillin era. Auxotypes and antibacterial drug resistances. Br J Vener Dis. 1982 Jun;58(3):158–165. doi: 10.1136/sti.58.3.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Chen S. T., Clowes R. C. Nucleotide sequence comparisons of plasmids pHD131, pJB1, pFA3, and pFA7 and beta-lactamase expression in Escherichia coli, Haemophilus influenzae, and Neisseria gonorrhoeae. J Bacteriol. 1987 Jul;169(7):3124–3130. doi: 10.1128/jb.169.7.3124-3130.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Covarrubias L., Cervantes L., Covarrubias A., Soberón X., Vichido I., Blanco A., Kupersztoch-Portnoy Y. M., Bolivar F. Construction and characterization of new cloning vehicles. V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328. Gene. 1981 Jan-Feb;13(1):25–35. doi: 10.1016/0378-1119(81)90040-8. [DOI] [PubMed] [Google Scholar]
  14. Dickgiesser N., Bennett P. M., Richmond M. H. Penicillinase-producing Neisseria gonorrhoeae: a molecular comparison of 5.3-kb and 7.4-kb beta-lactamase plasmids. J Bacteriol. 1982 Sep;151(3):1171–1175. doi: 10.1128/jb.151.3.1171-1175.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Dickgiesser N. beta-Laktamase-positive Neisseria gonorrhoeae. I. Untersuchungen von 3.2 MDalton- und 4.6 MDalton-Plasmiden mit Restriktionsendonukleasen und Transcription/Translation in vitro. Zentralbl Bakteriol Mikrobiol Hyg A. 1983 Feb;253(4):495–499. [PubMed] [Google Scholar]
  16. Dillon J. R., Bygdeman S. M., Sandström E. G. Serological ecology of Neisseria gonorrhoeae (PPNG and non-PPNG) strains: Canadian perspective. Genitourin Med. 1987 Jun;63(3):160–168. doi: 10.1136/sti.63.3.160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Dillon J. R., Pauzé M. Introductory address: resistance to antimicrobial agents. What next for Neisseria gonorrhoeae? Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):353–359. [PubMed] [Google Scholar]
  18. Dillon J. R., Pauzé M. Relationship between plasmid content and auxotype in Neisseria gonorrhoeae isolates. Infect Immun. 1981 Aug;33(2):625–628. doi: 10.1128/iai.33.2.625-628.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Dillon J. R., Pauzé M., Yeung K. H. Molecular and epidemiological analysis of penicillinase producing strains of Neisseria gonorrhoeae isolated in Canada 1976-84: evolution of new auxotypes and beta lactamase encoding plasmids. Genitourin Med. 1986 Jun;62(3):151–157. doi: 10.1136/sti.62.3.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Dillon J. R., Pauzé M., Yeung K. H. Spread of penicillinase-producing and transfer plasmids from the gonococcus to Neisseria meningitidis. Lancet. 1983 Apr 9;1(8328):779–781. doi: 10.1016/s0140-6736(83)91846-9. [DOI] [PubMed] [Google Scholar]
  21. Dougherty T. J. Genetic analysis and penicillin-binding protein alterations in Neisseria gonorrhoeae with chromosomally mediated resistance. Antimicrob Agents Chemother. 1986 Nov;30(5):649–652. doi: 10.1128/aac.30.5.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Dougherty T. J. Involvement of a change in penicillin target and peptidoglycan structure in low-level resistance to beta-lactam antibiotics in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1985 Jul;28(1):90–95. doi: 10.1128/aac.28.1.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Elwell L. P., Roberts M., Mayer L. W., Falkow S. Plasmid-mediated beta-lactamase production in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1977 Mar;11(3):528–533. doi: 10.1128/aac.11.3.528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Fayet O., Froment Y., Piffaretti J. C. Beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae have retained an intact right part of a Tn3-like transposon. J Bacteriol. 1982 Jan;149(1):136–144. doi: 10.1128/jb.149.1.136-144.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Gamas P., Burger A. C., Churchward G., Caro L., Galas D., Chandler M. Replication of pSC101: effects of mutations in the E. coli DNA binding protein IHF. Mol Gen Genet. 1986 Jul;204(1):85–89. doi: 10.1007/BF00330192. [DOI] [PubMed] [Google Scholar]
  26. Genco C. A., Knapp J. S., Clark V. L. Conjugation of plasmids of Neisseria gonorrhoeae to other Neisseria species: potential reservoirs for the beta-lactamase plasmid. J Infect Dis. 1984 Sep;150(3):397–401. doi: 10.1093/infdis/150.3.397. [DOI] [PubMed] [Google Scholar]
  27. Gouby A., Bourg G., Ramuz M. Previously undescribed 6.6-kilobase R plasmid in penicillinase-producing Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1986 Jun;29(6):1095–1097. doi: 10.1128/aac.29.6.1095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Guiney D. G., Jr, Ito J. I., Jr Transfer of the gonococcal penicillinase plasmid: mobilization in Escherichia coli by IncP plasmids and isolation as a DNA-protein relaxation complex. J Bacteriol. 1982 Apr;150(1):298–302. doi: 10.1128/jb.150.1.298-302.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Ho R. I., Corman L., Morse S. A., Artenstein M. S. Alterations in dihydropteroate synthetase in cell-free extracts of sulfanilamide-resistant Neisseria meningitidis and Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1974 Apr;5(4):388–392. doi: 10.1128/aac.5.4.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Ikeda F., Tsuji A., Kaneko Y., Nishida M., Goto S. Conjugal transfer of beta-lactamase-producing plasmids of Neisseria gonorrhoeae to Neisseria meningitidis. Microbiol Immunol. 1986;30(8):737–742. doi: 10.1111/j.1348-0421.1986.tb03000.x. [DOI] [PubMed] [Google Scholar]
  31. Ison C. A., Gedney J., Easmon C. S. Chromosomal resistance of gonococci to antibiotics. Genitourin Med. 1987 Aug;63(4):239–243. doi: 10.1136/sti.63.4.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Jones F., Cunningham E. J., Shockley T. E., Jackson J. H. Genetic analysis of spontaneous resistance to ampicillin in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1985 Jul;28(1):21–27. doi: 10.1128/aac.28.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Knapp J. S., Hook E. W., 3rd Prevalence and persistence of Neisseria cinerea and other Neisseria spp. in adults. J Clin Microbiol. 1988 May;26(5):896–900. doi: 10.1128/jcm.26.5.896-900.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Knapp J. S., Johnson S. R., Zenilman J. M., Roberts M. C., Morse S. A. High-level tetracycline resistance resulting from TetM in strains of Neisseria spp., Kingella denitrificans, and Eikenella corrodens. Antimicrob Agents Chemother. 1988 May;32(5):765–767. doi: 10.1128/aac.32.5.765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Koelbl J. A., Catlin B. W. Vancomycin hypersusceptibility in Neisseria gonorrhoeae isolated from patients involves diverse mutations. Antimicrob Agents Chemother. 1986 Apr;29(4):687–695. doi: 10.1128/aac.29.4.687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Leong J. M., Nunes-Düby S., Lesser C. F., Youderian P., Susskind M. M., Landy A. The phi 80 and P22 attachment sites. Primary structure and interaction with Escherichia coli integration host factor. J Biol Chem. 1985 Apr 10;260(7):4468–4477. [PubMed] [Google Scholar]
  37. Lysko P. G., Morse S. A. Neisseria gonorrhoeae cell envelope: permeability to hydrophobic molecules. J Bacteriol. 1981 Feb;145(2):946–952. doi: 10.1128/jb.145.2.946-952.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Maier T. W., Zubrzycki L., Coyle M. B. Genetic analysis of drug resistance in Neisseria gonorrhoeae: identification and linkage relationships of loci controlling drug resistance. Antimicrob Agents Chemother. 1975 May;7(5):676–681. doi: 10.1128/aac.7.5.676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Maness M. J., Sparling P. F. Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae. J Infect Dis. 1973 Sep;128(3):321–330. doi: 10.1093/infdis/128.3.321. [DOI] [PubMed] [Google Scholar]
  40. McIntire S. A., Dempsey W. B. oriT sequence of the antibiotic resistance plasmid R100. J Bacteriol. 1987 Aug;169(8):3829–3832. doi: 10.1128/jb.169.8.3829-3832.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. McNicol P. J., Albritton W. L., Ronald A. R. Characterization of ampicillin resistance plasmids of Haemophilus ducreyi and Neisseria gonorrhoeae with regard to location of origin of transfer and mobilization by a conjugative plasmid of Haemophilus ducreyi. J Bacteriol. 1983 Oct;156(1):437–440. doi: 10.1128/jb.156.1.437-440.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. McNicol P. J., Albritton W. L., Ronald A. R. Origin and direction of in vitro replication of Haemophilus ducreyi and Neisseria gonorrhoeae ampicillin resistance plasmids. J Bacteriol. 1984 Apr;158(1):393–395. doi: 10.1128/jb.158.1.393-395.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Mendelman P. M., Campos J., Chaffin D. O., Serfass D. A., Smith A. L., Sáez-Nieto J. A. Relative penicillin G resistance in Neisseria meningitidis and reduced affinity of penicillin-binding protein 3. Antimicrob Agents Chemother. 1988 May;32(5):706–709. doi: 10.1128/aac.32.5.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Peltola H. Meningococcal disease: still with us. Rev Infect Dis. 1983 Jan-Feb;5(1):71–91. doi: 10.1093/clinids/5.1.71. [DOI] [PubMed] [Google Scholar]
  45. Perine P. L., Thornsberry C., Schalla W., Biddle J., Siegel M. S., Wong K. H., Thompson S. E. Evidence for two distinct types of penicillinase-producing Neisseria gonorrhoeae. Lancet. 1977 Nov 12;2(8046):993–995. doi: 10.1016/s0140-6736(77)92891-4. [DOI] [PubMed] [Google Scholar]
  46. Phillips I. Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976 Sep 25;2(7987):656–657. doi: 10.1016/s0140-6736(76)92466-1. [DOI] [PubMed] [Google Scholar]
  47. Phillips I. Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976 Sep 25;2(7987):656–657. doi: 10.1016/s0140-6736(76)92466-1. [DOI] [PubMed] [Google Scholar]
  48. Piffaretti J. C., Arini A., Frey J. pUB307 mobilizes resistance plasmids from Escherichia coli into Neisseria gonorrhoeae. Mol Gen Genet. 1988 May;212(2):215–218. doi: 10.1007/BF00334687. [DOI] [PubMed] [Google Scholar]
  49. Rice R. J., Biddle J. W., JeanLouis Y. A., DeWitt W. E., Blount J. H., Morse S. A. Chromosomally mediated resistance in Neisseria gonorrhoeae in the United States: results of surveillance and reporting, 1983-1984. J Infect Dis. 1986 Feb;153(2):340–345. doi: 10.1093/infdis/153.2.340. [DOI] [PubMed] [Google Scholar]
  50. Roberts M. C., Knapp J. S. Host range of the conjugative 25.2-megadalton tetracycline resistance plasmid from Neisseria gonorrhoeae and related species. Antimicrob Agents Chemother. 1988 Apr;32(4):488–491. doi: 10.1128/aac.32.4.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Roberts M. C. Plasmids of Neisseria gonorrhoeae and other Neisseria species. Clin Microbiol Rev. 1989 Apr;2 (Suppl):S18–S23. doi: 10.1128/cmr.2.suppl.s18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Roberts M., Elwell L. P., Falkow S. Molecular characterization of two beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae. J Bacteriol. 1977 Aug;131(2):557–563. doi: 10.1128/jb.131.2.557-563.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Robinson P., Bergquist P., Lane D. Analysis of a region in plasmid R386 containing two functional replicons. Plasmid. 1985 Jul;14(1):28–36. doi: 10.1016/0147-619x(85)90029-0. [DOI] [PubMed] [Google Scholar]
  54. Sanchez-Pescador R., Stempien M. S., Urdea M. S. Rapid chemiluminescent nucleic acid assays for detection of TEM-1 beta-lactamase-mediated penicillin resistance in Neisseria gonorrhoeae and other bacteria. J Clin Microbiol. 1988 Oct;26(10):1934–1938. doi: 10.1128/jcm.26.10.1934-1938.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Sarubbi F. A., Jr, Sparling P. F., Blackman E., Lewis E. Loss of low-level antibiotic resistance in Neisseria gonorrhoeae due to env mutations. J Bacteriol. 1975 Nov;124(2):750–756. doi: 10.1128/jb.124.2.750-756.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Shafer W. M., Guymon L. F., Lind I., Sparling P. F. Identification of an envelope mutation (env-10) resulting in increased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1984 Jun;25(6):767–769. doi: 10.1128/aac.25.6.767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Shinners E. N., Catlin B. W. Mutation in a locus linked to penB-nmp causes suppression of the Mtr phenotype of Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1988 Jul;32(7):971–977. doi: 10.1128/aac.32.7.971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Shtibel R. Non-beta-lactamase producing Neisseria gonorrhorea highly resistant to penicillin. Lancet. 1980 Jul 5;2(8184):39–39. doi: 10.1016/s0140-6736(80)92917-7. [DOI] [PubMed] [Google Scholar]
  59. Sox T. E., Mohammed W., Sparling P. F. Transformation-derived Neisseria gonorrhoeae plasmids with altered structure and function. J Bacteriol. 1979 May;138(2):510–518. doi: 10.1128/jb.138.2.510-518.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Sparling P. F. Genetic transformation of Neisseria gonorrhoeae to streptomycin resistance. J Bacteriol. 1966 Nov;92(5):1364–1371. doi: 10.1128/jb.92.5.1364-1371.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Sparling P. F., Sarubbi F. A., Jr, Blackman E. Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae. J Bacteriol. 1975 Nov;124(2):740–749. doi: 10.1128/jb.124.2.740-749.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Sutcliffe E. M., Jones D. M., el-Sheikh S., Percival A. Penicillin-insensitive meningococci in the UK. Lancet. 1988 Mar 19;1(8586):657–658. doi: 10.1016/s0140-6736(88)91469-9. [DOI] [PubMed] [Google Scholar]
  63. Tenover F. C., Stein D. C., Young F. E., Clark V. L. Construction and characterization of chimeric beta-lactamase plasmids of Neisseria gonorrhoeae with altered ability to be mobilized during conjugation. Sex Transm Dis. 1985 Apr-Jun;12(2):76–82. doi: 10.1097/00007435-198504000-00005. [DOI] [PubMed] [Google Scholar]
  64. Timmis K., Cabello F., Cohen S. N. Cloning, isolation, and characterization of replication regions of complex plasmid genomes. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2242–2246. doi: 10.1073/pnas.72.6.2242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Van Embden J. D., Dessens-Kroon M., Van Klingeren B. A new beta-lactamase plasmid in Neisseria gonorrhoeae. J Antimicrob Chemother. 1985 Feb;15(2):247–250. doi: 10.1093/jac/15.2.247. [DOI] [PubMed] [Google Scholar]
  66. Warner P. F., Zubrzycki L. J., Chila M. Polygenes and modifier genes for tetracycline and penicillin resistance in Neisseria gonorrhoeae. J Gen Microbiol. 1980 Mar;117(1):103–110. doi: 10.1099/00221287-117-1-103. [DOI] [PubMed] [Google Scholar]
  67. Willetts N., Wilkins B. Processing of plasmid DNA during bacterial conjugation. Microbiol Rev. 1984 Mar;48(1):24–41. doi: 10.1128/mr.48.1.24-41.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Yeung K. H., Dillon J. R., Pauzé M., Wallace E. A novel 4.9-kilobase plasmid associated with an outbreak of penicillinase-producing Neisseria gonorrhoeae. J Infect Dis. 1986 Jun;153(6):1162–1165. doi: 10.1093/infdis/153.6.1162. [DOI] [PubMed] [Google Scholar]
  69. van Embden J. D., van Klingeren B., Dessens-Kroon M., van Wijngaarden L. J. Emergence in the Netherlands of penicillinase-producing gonococci carrying "Africa" plasmid in combination with transfer plasmid. Lancet. 1981 Apr 25;1(8226):938–938. doi: 10.1016/s0140-6736(81)91630-5. [DOI] [PubMed] [Google Scholar]
  70. van Klingeren B., Ansink-Schipper M. C., Doornbos L., Lampe A. S., Wagenvoort J. H., Dessens-Kroon M., Verheuvel M. Surveillance of the antibiotic susceptibility of non-penicillinase producing Neisseria gonorrhoeae in The Netherlands from 1983 to 1986. J Antimicrob Chemother. 1988 Jun;21(6):737–744. doi: 10.1093/jac/21.6.737. [DOI] [PubMed] [Google Scholar]

Articles from Clinical Microbiology Reviews are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES