Abstract
Human cytomegalovirus (CMV) is a ubiquitous deoxyribonucleic acid virus that commonly infects a majority of individuals at some time during their life. Although most of these CMV infections are asymptomatic, certain patient groups are at risk to develop serious illness. Understanding the epidemiology of this virus is a key element in the development of strategies for preventing CMV disease. However, a number of features of this virus complicate such understanding. Following infection, CMV can remain latent, with subsequent reactivation; the factors controlling latency and reactivation and those factors which determine whether a CMV infection will be symptomatic are unknown. CMV disease can be acquired by natural routes, including horizontal and vertical transmission. Due to the ubiquity of CMV, the delineation of CMV transmission by these natural routes is complicated by the myriad of possible sources. Moreover, concerns over the risk of CMV transmission to the seronegative pregnant female have been raised in relation to preventing CMV transmission. By using molecular biologic techniques, much knowledge has been gained regarding the transmission of CMV disease by natural routes; however, a number of questions remain unanswered. The transmission of CMV infection by natural routes is therefore reviewed and the issues are highlighted. Primary infection, reactivation, and reinfection are the types of active CMV infections that can occur in an immunocompromised patient. In addition to natural routes of infection, introduction of presumably latently infected organs and requirements for multiple blood transfusions increase potential exposure to CMV in the immunocompromised patient. Understanding the epidemiology of CMV infections in the immunocompromised patient is difficult and in some instances controversial due to the complexity and interdependency of a number of factors which lead to CMV infection. In an immunocompromised individual, a major risk factor in developing overt CMV-related disease is associated with the serological status of an organ donor, the recipient, and the blood product given to these patients. In addition, a large body of inferential data supports the transmission of CMV by blood products or organs from seropositive donors; however, the mechanisms by which transmission occurs remain unclear. The possible sources and mechanisms of transmission of CMV infections in the immunocompromised host are reviewed. Lastly, strategies for the ultimate prevention of CMV disease are discussed in light of the epidemiology of CMV infections. To date, these strategies have included use of CMV-seronegative blood products or organs, antiviral agents, and vaccines.(ABSTRACT TRUNCATED AT 400 WORDS)
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ackermann J. R., LeFor W. M., Weinstein S., Kahana L., Shires D. L., Tardif G., Baxter J. Four-year experience with exclusive use of cytomegalovirus antibody (CMV-Ab)-negative donors for CMV-Ab-negative kidney recipients. Transplant Proc. 1988 Feb;20(1 Suppl 1):469–471. [PubMed] [Google Scholar]
- Adler S. P., Baggett J., Wilson M., Lawrence L., McVoy M. Molecular epidemiology of cytomegalovirus in a nursery: lack of evidence for nosocomial transmission. J Pediatr. 1986 Jan;108(1):117–123. doi: 10.1016/s0022-3476(86)80785-5. [DOI] [PubMed] [Google Scholar]
- Adler S. P., Chandrika T., Lawrence L., Baggett J. Cytomegalovirus infections in neonates acquired by blood transfusions. Pediatr Infect Dis. 1983 Mar-Apr;2(2):114–118. doi: 10.1097/00006454-198303000-00009. [DOI] [PubMed] [Google Scholar]
- Adler S. P. Molecular epidemiology of cytomegalovirus: evidence for viral transmission to parents from children infected at a day care center. Pediatr Infect Dis. 1986 May-Jun;5(3):315–318. [PubMed] [Google Scholar]
- Adler S. P. Molecular epidemiology of cytomegalovirus: viral transmission among children attending a day care center, their parents, and caretakers. J Pediatr. 1988 Mar;112(3):366–372. doi: 10.1016/s0022-3476(88)80314-7. [DOI] [PubMed] [Google Scholar]
- Adler S. P. The molecular epidemiology of cytomegalovirus transmission among children attending a day care center. J Infect Dis. 1985 Oct;152(4):760–768. doi: 10.1093/infdis/152.4.760. [DOI] [PubMed] [Google Scholar]
- Adler S. P. Transfusion-associated cytomegalovirus infections. Rev Infect Dis. 1983 Nov-Dec;5(6):977–993. doi: 10.1093/clinids/5.6.977. [DOI] [PubMed] [Google Scholar]
- Akesson-Johansson A., Lernestedt J. O., Ringdén O., Lönnqvist B., Wahren B. Sensitivity of cytomegalovirus to intravenous foscarnet treatment. Bone Marrow Transplant. 1986 Dec;1(2):215–220. [PubMed] [Google Scholar]
- Balfour C. L., Balfour H. H., Jr Cytomegalovirus is not an occupational risk for nurses in renal transplant and neonatal units. Results of a prospective surveillance study. JAMA. 1986 Oct 10;256(14):1909–1914. [PubMed] [Google Scholar]
- Balfour H. H., Jr, Slade M. S., Kalis J. M., Howard R. J., Simmons R. L., Najarian J. S. Viral infections in renal transplant donors and their recipients: a prospective study. Surgery. 1977 May;81(5):487–492. [PubMed] [Google Scholar]
- Bayer W. L., Tegtmeier G. E. The blood donor: detection and magnitude of cytomegalovirus carrier states and the prevalence of cytomegalovirus antibody. Yale J Biol Med. 1976 Mar;49(1):5–12. [PMC free article] [PubMed] [Google Scholar]
- Beneke J. S., Tegtmeier G. E., Alter H. J., Luetkemeyer R. B., Solomon R., Bayer W. L. Relation of titers of antibodies to CMV in blood donors to the transmission of cytomegalovirus infection. J Infect Dis. 1984 Dec;150(6):883–888. doi: 10.1093/infdis/150.6.883. [DOI] [PubMed] [Google Scholar]
- Betts R. F., Cestero R. V., Freeman R. B., Douglas R. G., Jr Epidemiology of cytomegalovirus infection in end stage renal disease. J Med Virol. 1979;4(2):89–96. doi: 10.1002/jmv.1890040203. [DOI] [PubMed] [Google Scholar]
- Betts R. F., Freeman R. B., Douglas R. G., Jr, Talley T. E. Clinical manifestations of renal allograft derived primary cytomegalovirus infection. Am J Dis Child. 1977 Jul;131(7):759–763. doi: 10.1001/archpedi.1977.02120200041010. [DOI] [PubMed] [Google Scholar]
- Betts R. F., Schmidt S. G. Cytolytic IgM antibody to cytomegalovirus in primary cytomegalovirus infection in humans. J Infect Dis. 1981 Jun;143(6):821–826. doi: 10.1093/infdis/143.6.821. [DOI] [PubMed] [Google Scholar]
- Betts R. F. The relationship of epidemiology and treatment factors to infection and allograft survival in renal transplantation. Birth Defects Orig Artic Ser. 1984;20(1):87–99. [PubMed] [Google Scholar]
- Bracken M. C., Stokes J. J., Toth R. A., Ramsey G. Detection of cytomegalovirus antibody in stored blood components. Transfusion. 1988 May-Jun;28(3):291–292. doi: 10.1046/j.1537-2995.1988.28388219169.x. [DOI] [PubMed] [Google Scholar]
- Braun R. W., Reiser H. C. Replication of human cytomegalovirus in human peripheral blood T cells. J Virol. 1986 Oct;60(1):29–36. doi: 10.1128/jvi.60.1.29-36.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chandler S. H., Handsfield H. H., McDougall J. K. Isolation of multiple strains of cytomegalovirus from women attending a clinic for sexually transmitted disease. J Infect Dis. 1987 Apr;155(4):655–660. doi: 10.1093/infdis/155.4.655. [DOI] [PubMed] [Google Scholar]
- Chou S. W. Acquisition of donor strains of cytomegalovirus by renal-transplant recipients. N Engl J Med. 1986 May 29;314(22):1418–1423. doi: 10.1056/NEJM198605293142205. [DOI] [PubMed] [Google Scholar]
- Chou S., Kim D. Y., Norman D. J. Transmission of cytomegalovirus by pretransplant leukocyte transfusions in renal transplant candidates. J Infect Dis. 1987 Mar;155(3):565–567. doi: 10.1093/infdis/155.3.565. [DOI] [PubMed] [Google Scholar]
- Conboy T. J., Pass R. F., Stagno S., Alford C. A., Myers G. J., Britt W. J., McCollister F. P., Summers M. N., McFarland C. E., Boll T. J. Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr. 1987 Sep;111(3):343–348. doi: 10.1016/s0022-3476(87)80451-1. [DOI] [PubMed] [Google Scholar]
- Condie R. M., O'Reilly R. J. Prevention of cytomegalovirus infection by prophylaxis with an intravenous, hyperimmune, native, unmodified cytomegalovirus globulin. Randomized trial in bone marrow transplant recipients. Am J Med. 1984 Mar 30;76(3A):134–141. doi: 10.1016/0002-9343(84)90332-2. [DOI] [PubMed] [Google Scholar]
- Craft A. W., Hamilton P. J., McQuillin J., Scott D. J., Walker W. Fatal dissemination of cytomegalovirus after bone marrow transplantation. J Clin Pathol. 1981 Sep;34(9):1047–1051. doi: 10.1136/jcp.34.9.1047. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Craighead J. E., Hanshaw J. B., Carpenter C. B. Cytomegalovirus infection after renal allotransplantation. JAMA. 1967 Sep 4;201(10):725–728. [PubMed] [Google Scholar]
- DeMarchi J. M., Kaplan A. S. Replication of human cytomegalovirus DNA: lack of dependence on cell DNA synthesis. J Virol. 1976 Jun;18(3):1063–1070. doi: 10.1128/jvi.18.3.1063-1070.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DeMarchi J. M. The physical and transcriptional organization of the human cytomegalovirus genome. Birth Defects Orig Artic Ser. 1984;20(1):35–47. [PubMed] [Google Scholar]
- Demmler G. J., Brady M. T., Bijou H., Speer M. E., Milam J. D., Hawkins E. P., Anderson D. C., Six H., Yow M. D. Posttransfusion cytomegalovirus infection in neonates: role of saline-washed red blood cells. J Pediatr. 1986 May;108(5 Pt 1):762–765. doi: 10.1016/s0022-3476(86)81062-9. [DOI] [PubMed] [Google Scholar]
- Demmler G. J., O'Neil G. W., O'Neil J. H., Spector S. A., Brady M. T., Yow M. D. Transmission of cytomegalovirus from husband to wife. J Infect Dis. 1986 Sep;154(3):545–546. doi: 10.1093/infdis/154.3.545. [DOI] [PubMed] [Google Scholar]
- Demmler G. J., Six H. R., Hurst S. M., Yow M. D. Enzyme-linked immunosorbent assay for the detection of IgM-class antibodies to cytomegalovirus. J Infect Dis. 1986 Jun;153(6):1152–1155. doi: 10.1093/infdis/153.6.1152. [DOI] [PubMed] [Google Scholar]
- Demmler G. J., Yow M. D., Spector S. A., Reis S. G., Brady M. T., Anderson D. C., Taber L. H. Nosocomial cytomegalovirus infections within two hospitals caring for infants and children. J Infect Dis. 1987 Jul;156(1):9–16. doi: 10.1093/infdis/156.1.9. [DOI] [PubMed] [Google Scholar]
- Diosi P., Moldovan E., Tomescu N. Latent cytomegalovirus infection in blood donors. Br Med J. 1969 Dec 13;4(5684):660–662. doi: 10.1136/bmj.4.5684.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doerr H. W. Cytomegalovirus infection in pregnancy. J Virol Methods. 1987 Aug;17(1-2):127–132. doi: 10.1016/0166-0934(87)90075-9. [DOI] [PubMed] [Google Scholar]
- Drew W. L., Sweet E. S., Miner R. C., Mocarski E. S. Multiple infections by cytomegalovirus in patients with acquired immunodeficiency syndrome: documentation by Southern blot hybridization. J Infect Dis. 1984 Dec;150(6):952–953. doi: 10.1093/infdis/150.6.952. [DOI] [PubMed] [Google Scholar]
- Dummer J. S., White L. T., Ho M., Griffith B. P., Hardesty R. L., Bahnson H. T. Morbidity of cytomegalovirus infection in recipients of heart or heart-lung transplants who received cyclosporine. J Infect Dis. 1985 Dec;152(6):1182–1191. doi: 10.1093/infdis/152.6.1182. [DOI] [PubMed] [Google Scholar]
- Dutko F. J., Oldstone M. B. Cytomegalovirus causes a latent infection in undifferentiated cells and is activated by induction of cell differentiation. J Exp Med. 1981 Nov 1;154(5):1636–1651. doi: 10.1084/jem.154.5.1636. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dworsky M., Yow M., Stagno S., Pass R. F., Alford C. Cytomegalovirus infection of breast milk and transmission in infancy. Pediatrics. 1983 Sep;72(3):295–299. [PubMed] [Google Scholar]
- Einhorn L., Ost A. Cytomegalovirus infection of human blood cells. J Infect Dis. 1984 Feb;149(2):207–214. doi: 10.1093/infdis/149.2.207. [DOI] [PubMed] [Google Scholar]
- Elek S. D., Stern H. Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero. Lancet. 1974 Jan 5;1(7845):1–5. doi: 10.1016/s0140-6736(74)92997-3. [DOI] [PubMed] [Google Scholar]
- Emanuel D., Cunningham I., Jules-Elysee K., Brochstein J. A., Kernan N. A., Laver J., Stover D., White D. A., Fels A., Polsky B. Cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high-dose intravenous immune globulin. Ann Intern Med. 1988 Nov 15;109(10):777–782. doi: 10.7326/0003-4819-109-10-777. [DOI] [PubMed] [Google Scholar]
- Erice A., Jordan M. C., Chace B. A., Fletcher C., Chinnock B. J., Balfour H. H., Jr Ganciclovir treatment of cytomegalovirus disease in transplant recipients and other immunocompromised hosts. JAMA. 1987 Jun 12;257(22):3082–3087. [PubMed] [Google Scholar]
- Faix R. G. Survival of cytomegalovirus on environmental surfaces. J Pediatr. 1985 Apr;106(4):649–652. doi: 10.1016/s0022-3476(85)80096-2. [DOI] [PubMed] [Google Scholar]
- Farthing C., Anderson M. G., Ellis M. E., Gazzard B. G., Chanas A. C. Treatment of cytomegalovirus pneumonitis with foscarnet (trisodium phosphonoformate) in patients with AIDS. J Med Virol. 1987 Jun;22(2):157–162. doi: 10.1002/jmv.1890220206. [DOI] [PubMed] [Google Scholar]
- Faucon-Biguet N., Siqueira-Linhares M. I., Chardonnet Y., Revillard J. P. Sequential changes in cytomegalovirus antigenic pattern during infection of renal transplant patients. Microbios. 1986;45(183):71–80. [PubMed] [Google Scholar]
- Fiala M., Payne J. E., Berne T. V., Moore T. C., Henle W., Montgomerie J. Z., Chatterjee S. N., Guze L. B. Epidemiology of cytomegalovirus infection after transplantation and immunosuppression. J Infect Dis. 1975 Oct;132(4):421–433. doi: 10.1093/infdis/132.4.421. [DOI] [PubMed] [Google Scholar]
- Friedman H. M., Lewis M. R., Nemerofsky D. M., Plotkin S. A. Acquisition of cytomegalovirus infection among female employees at a pediatric hospital. Pediatr Infect Dis. 1984 May-Jun;3(3):233–235. doi: 10.1097/00006454-198405000-00010. [DOI] [PubMed] [Google Scholar]
- Garnett H. M. Isolation of human cytomegalovirus from peripheral blood T cells of renal transplant patients. J Lab Clin Med. 1982 Jan;99(1):92–97. [PubMed] [Google Scholar]
- Glazer J. P., Friedman H. M., Grossman R. A., Starr S. E., Barker C. F., Perloff L. J., Huang E. S., Plotkin S. A. Live cytomegalovirus vaccination of renal transplant candidates. A preliminary trial. Ann Intern Med. 1979 Nov;91(5):676–683. doi: 10.7326/0003-4819-91-5-676. [DOI] [PubMed] [Google Scholar]
- Glenn J. Cytomegalovirus infections following renal transplantation. Rev Infect Dis. 1981 Nov-Dec;3(6):1151–1178. doi: 10.1093/clinids/3.6.1151. [DOI] [PubMed] [Google Scholar]
- Gnann J. W., Jr, Ahlmén J., Svalander C., Olding L., Oldstone M. B., Nelson J. A. Inflammatory cells in transplanted kidneys are infected by human cytomegalovirus. Am J Pathol. 1988 Aug;132(2):239–248. [PMC free article] [PubMed] [Google Scholar]
- Goff E., Griffith B. P., Booss J. Delayed amplification of cytomegalovirus infection in the placenta and maternal tissues during late gestation. Am J Obstet Gynecol. 1987 May;156(5):1265–1270. doi: 10.1016/0002-9378(87)90159-1. [DOI] [PubMed] [Google Scholar]
- Gorensek M. J., Stewart R. W., Keys T. F., McHenry M. C., Goormastic M. A multivariate analysis of the risk of cytomegalovirus infection in heart transplant recipients. J Infect Dis. 1988 Mar;157(3):515–522. doi: 10.1093/infdis/157.3.515. [DOI] [PubMed] [Google Scholar]
- Griffiths P. D., Stagno S., Pass R. F., Smith R. J., Alford C. A., Jr Infection with cytomegalovirus during pregnancy: specific IgM antibodies as a marker of recent primary infection. J Infect Dis. 1982 May;145(5):647–653. doi: 10.1093/infdis/145.2.647. [DOI] [PubMed] [Google Scholar]
- Grundy J. E., Shanley J. D., Shearer G. M. Augmentation of graft-versus-host reaction by cytomegalovirus infection resulting in interstitial pneumonitis. Transplantation. 1985 May;39(5):548–553. doi: 10.1097/00007890-198505000-00018. [DOI] [PubMed] [Google Scholar]
- Gönczöl E., Andrews P. W., Plotkin S. A. Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells. Science. 1984 Apr 13;224(4645):159–161. doi: 10.1126/science.6322309. [DOI] [PubMed] [Google Scholar]
- Hamilton J. D., Seaworth B. J. Transmission of latent cytomegalovirus in a murine kidney tissue transplantation model. Transplantation. 1985 Mar;39(3):290–296. doi: 10.1097/00007890-198503000-00017. [DOI] [PubMed] [Google Scholar]
- Handsfield H. H., Chandler S. H., Caine V. A., Meyers J. D., Corey L., Medeiros E., McDougall J. K. Cytomegalovirus infection in sex partners: evidence for sexual transmission. J Infect Dis. 1985 Feb;151(2):344–348. doi: 10.1093/infdis/151.2.344. [DOI] [PubMed] [Google Scholar]
- Hayes K., Danks D. M., Gibas H., Jack I. Cytomegalovirus in human milk. N Engl J Med. 1972 Jul 27;287(4):177–178. doi: 10.1056/NEJM197207272870407. [DOI] [PubMed] [Google Scholar]
- Hecht D. W., Snydman D. R., Crumpacker C. S., Werner B. G., Heinze-Lacey B. Ganciclovir for treatment of renal transplant-associated primary cytomegalovirus pneumonia. J Infect Dis. 1988 Jan;157(1):187–190. doi: 10.1093/infdis/157.1.187. [DOI] [PubMed] [Google Scholar]
- Hekker A. C., Brand-Saathof B., Vis J., Meijers R. C. Indirect immunofluorescence test for detection of IgM antibodies to cytomegalovirus. J Infect Dis. 1979 Oct;140(4):596–600. doi: 10.1093/infdis/140.4.596. [DOI] [PubMed] [Google Scholar]
- Hersman J., Meyers J. D., Thomas E. D., Buckner C. D., Clift R. The effect of granulocyte transfusions on the incidence of cytomegalovirus infection after allogeneic marrow transplantation. Ann Intern Med. 1982 Feb;96(2):149–152. doi: 10.7326/0003-4819-96-2-149. [DOI] [PubMed] [Google Scholar]
- Hirsch M. S. Cytomegalovirus-leukocyte interactions. Birth Defects Orig Artic Ser. 1984;20(1):161–173. [PubMed] [Google Scholar]
- Ho M., Dowling J. N., Armstrong J. A., Suwansirikul S., Wu B., Youngblood L. A., Saslow A. Factors contributing to the risk of cytomegalovirus infection in patients receiving renal transplants. Yale J Biol Med. 1976 Mar;49(1):17–26. [PMC free article] [PubMed] [Google Scholar]
- Ho M., Suwansirikul S., Dowling J. N., Youngblood L. A., Armstrong J. A. The transplanted kidney as a source of cytomegalovirus infection. N Engl J Med. 1975 Nov 27;293(22):1109–1112. doi: 10.1056/NEJM197511272932201. [DOI] [PubMed] [Google Scholar]
- Huang E. S., Alford C. A., Reynolds D. W., Stagno S., Pass R. F. Molecular epidemiology of cytomegalovirus infections in women and their infants. N Engl J Med. 1980 Oct 23;303(17):958–962. doi: 10.1056/NEJM198010233031702. [DOI] [PubMed] [Google Scholar]
- Huang E. S., Huong S. M., Tegtmeier G. E., Alford C. Cytomegalovirus: genetic variation of viral genomes. Ann N Y Acad Sci. 1980;354:332–346. doi: 10.1111/j.1749-6632.1980.tb27976.x. [DOI] [PubMed] [Google Scholar]
- Huang E. S., Roche J. K. Cytomegalovirus D.N.A. and adenocarcinoma of the colon: Evidence for latent viral infection. Lancet. 1978 May 6;1(8071):957–960. doi: 10.1016/s0140-6736(78)90248-9. [DOI] [PubMed] [Google Scholar]
- Hutto C., Little E. A., Ricks R., Lee J. D., Pass R. F. Isolation of cytomegalovirus from toys and hands in a day care center. J Infect Dis. 1986 Sep;154(3):527–530. doi: 10.1093/infdis/154.3.527. [DOI] [PubMed] [Google Scholar]
- Jacobson M. A., Mills J. Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment. Ann Intern Med. 1988 Apr;108(4):585–594. doi: 10.7326/0003-4819-108-4-585. [DOI] [PubMed] [Google Scholar]
- Jordan M. C. Latent infection and the elusive cytomegalovirus. Rev Infect Dis. 1983 Mar-Apr;5(2):205–215. doi: 10.1093/clinids/5.2.205. [DOI] [PubMed] [Google Scholar]
- Jordan M. C., Rousseau W. E., Noble G. R., Steward J. A., Chin T. D. Association of cervical cytomegaloviruses with venereal disease. N Engl J Med. 1973 May 3;288(18):932–934. doi: 10.1056/NEJM197305032881803. [DOI] [PubMed] [Google Scholar]
- Kaiser C. J., Radsak K. Inhibition by monensin of human cytomegalovirus DNA replication. Arch Virol. 1987;94(3-4):229–245. doi: 10.1007/BF01310716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kane R. C., Rousseau W. E., Noble G. R., Tegtmeier G. E., Wulff H., Herndon H. B., Chin T. D., Bayer W. L. Cytomegalovirus infection in a volunteer blood donor population. Infect Immun. 1975 Apr;11(4):719–723. doi: 10.1128/iai.11.4.719-723.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kirchner H. Immunobiology of infection with human cytomegalovirus. Adv Cancer Res. 1983;40:31–105. doi: 10.1016/s0065-230x(08)60679-x. [DOI] [PubMed] [Google Scholar]
- Klotman M. E., Starnes D., Hamilton J. D. The source of murine cytomegalovirus in mice receiving kidney allografts. J Infect Dis. 1985 Dec;152(6):1192–1196. doi: 10.1093/infdis/152.6.1192. [DOI] [PubMed] [Google Scholar]
- Knox G. E., Pass R. F., Reynolds D. W., Stagno S., Alford C. A. Comparative prevalence of subclinical cytomegalovirus and herpes simplex virus infections in the genital and urinary tracts of low-income, urban women. J Infect Dis. 1979 Sep;140(3):419–422. doi: 10.1093/infdis/140.3.419. [DOI] [PubMed] [Google Scholar]
- Kumar M. L., Nankervis G. A., Cooper A. R., Gold E. Postnatally acquired cytomegalovirus infections in infants of CMV-excreting mothers. J Pediatr. 1984 May;104(5):669–673. doi: 10.1016/s0022-3476(84)80941-5. [DOI] [PubMed] [Google Scholar]
- Lang D. J. Cytomegalovirus infections in organ transplantation and post transfusion. An hypothesis. Arch Gesamte Virusforsch. 1972;37(4):365–377. doi: 10.1007/BF01241460. [DOI] [PubMed] [Google Scholar]
- Lang D. J., Scolnick E. M., Willerson J. T. Association of cytomegalovirus infection with the postperfusion syndrome. N Engl J Med. 1968 May 23;278(21):1147–1149. doi: 10.1056/NEJM196805232782105. [DOI] [PubMed] [Google Scholar]
- Lentz E. B., Dock N. L., McMahon C. A., Fiesthumel S. R., Arnold C. B., Lamberson H. V., Jr Detection of antibody to cytomegalovirus-induced early antigens and comparison with four serologic assays and presence of viruria in blood donors. J Clin Microbiol. 1988 Jan;26(1):133–135. doi: 10.1128/jcm.26.1.133-135.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Luthardt T., Siebert H., Lösel I., Quevedo M., Todt R. Cytomegalievirus-infektionen bei Kindern mit Blutaustauschtransfusion im Neugeborenenalter. Klin Wochenschr. 1971 Jan 15;49(2):81–86. doi: 10.1007/BF01497304. [DOI] [PubMed] [Google Scholar]
- Mar E. C., Cheng Y. C., Huang E. S. Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro. Antimicrob Agents Chemother. 1983 Oct;24(4):518–521. doi: 10.1128/aac.24.4.518. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mayo D. R., Armstrong J. A., Ho M. Reactivation of murine cytomegalovirus by cyclophosphamide. Nature. 1977 Jun 23;267(5613):721–723. doi: 10.1038/267721a0. [DOI] [PubMed] [Google Scholar]
- McDonough S. H., Spector D. H. Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169. Virology. 1983 Feb;125(1):31–46. doi: 10.1016/0042-6822(83)90061-2. [DOI] [PubMed] [Google Scholar]
- McFarlane E. S., Koment R. W. Use of restriction endonuclease digestion to analyze strains of human cytomegalovirus isolated concurrently from an immunocompetent heterosexual man. J Infect Dis. 1986 Jul;154(1):167–168. doi: 10.1093/infdis/154.1.167. [DOI] [PubMed] [Google Scholar]
- Meyers J. D., Flournoy N., Thomas E. D. Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years' experience. Rev Infect Dis. 1982 Nov-Dec;4(6):1119–1132. doi: 10.1093/clinids/4.6.1119. [DOI] [PubMed] [Google Scholar]
- Meyers J. D., Leszczynski J., Zaia J. A., Flournoy N., Newton B., Snydman D. R., Wright G. G., Levin M. J., Thomas E. D. Prevention of cytomegalovirus infection by cytomegalovirus immune globulin after marrow transplantation. Ann Intern Med. 1983 Apr;98(4):442–446. doi: 10.7326/0003-4819-98-4-442. [DOI] [PubMed] [Google Scholar]
- Meyers J. D., Reed E. C., Shepp D. H., Thornquist M., Dandliker P. S., Vicary C. A., Flournoy N., Kirk L. E., Kersey J. H., Thomas E. D. Acyclovir for prevention of cytomegalovirus infection and disease after allogeneic marrow transplantation. N Engl J Med. 1988 Jan 14;318(2):70–75. doi: 10.1056/NEJM198801143180202. [DOI] [PubMed] [Google Scholar]
- Middeldorp J. M., Jongsma J., ter Haar A., Schirm J., The T. H. Detection of immunoglobulin M and G antibodies against cytomegalovirus early and late antigens by enzyme-linked immunosorbent assay. J Clin Microbiol. 1984 Oct;20(4):763–771. doi: 10.1128/jcm.20.4.763-771.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mirkovic R., Werch J., South M. A., Benyesh-Melnick M. Incidence of cytomegaloviremia in blood-bank donors and in infants with congenital cytomegalic inclusion disease. Infect Immun. 1971 Jan;3(1):45–50. doi: 10.1128/iai.3.1.45-50.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moran K. T., Thupari J. N., O'Reilly T. J., Munster A. M. Effect of immunoglobulin G therapy on serum antibody titers to cytomegalovirus in burn patients. Am J Surg. 1988 Feb;155(2):294–297. doi: 10.1016/s0002-9610(88)80718-9. [DOI] [PubMed] [Google Scholar]
- Murph J. R., Bale J. F., Jr, Murray J. C., Stinski M. F., Perlman S. Cytomegalovirus transmission in a Midwest day care center: possible relationship to child care practices. J Pediatr. 1986 Jul;109(1):35–39. doi: 10.1016/s0022-3476(86)80568-6. [DOI] [PubMed] [Google Scholar]
- Myerson D., Hackman R. C., Nelson J. A., Ward D. C., McDougall J. K. Widespread presence of histologically occult cytomegalovirus. Hum Pathol. 1984 May;15(5):430–439. doi: 10.1016/s0046-8177(84)80076-3. [DOI] [PubMed] [Google Scholar]
- Nankervis G. A. Cytomegalovirus infections in the blood recipient. Yale J Biol Med. 1976 Mar;49(1):13–15. [PMC free article] [PubMed] [Google Scholar]
- Naraqi S., Jackson G. G., Jonasson O., Yamashiroya H. M. Prospective study of prevalence, incidence, and source of herpesvirus infections in patients with renal allografts. J Infect Dis. 1977 Oct;136(4):531–540. doi: 10.1093/infdis/136.4.531. [DOI] [PubMed] [Google Scholar]
- Nelson J. A., Fleckenstein B., Galloway D. A., McDougall J. K. Transformation of NIH 3T3 cells with cloned fragments of human cytomegalovirus strain AD169. J Virol. 1982 Jul;43(1):83–91. doi: 10.1128/jvi.43.1.83-91.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Onorato I. M., Morens D. M., Martone W. J., Stansfield S. K. Epidemiology of cytomegaloviral infections: recommendations for prevention and control. Rev Infect Dis. 1985 Jul-Aug;7(4):479–497. doi: 10.1093/clinids/7.4.479. [DOI] [PubMed] [Google Scholar]
- Opelz G. Improved kidney graft survival in nontransfused recipients. Transplant Proc. 1987 Feb;19(1 Pt 1):149–152. [PubMed] [Google Scholar]
- Opelz G., Terasaki P. I. Dominant effect of transfusions on kidney graft survival. Transplantation. 1980 Feb;29(2):153–158. doi: 10.1097/00007890-198002000-00013. [DOI] [PubMed] [Google Scholar]
- Oram J. D., Downing R. G., Akrigg A., Dollery A. A., Duggleby C. J., Wilkinson G. W., Greenaway P. J. Use of recombinant plasmids to investigate the structure of the human cytomegalovirus genome. J Gen Virol. 1982 Mar;59(Pt 1):111–129. doi: 10.1099/0022-1317-59-1-111. [DOI] [PubMed] [Google Scholar]
- Orsi E. V., Howard J. L., Baturay N., Ende N., Ribot S., Eslami H. High incidence of virus isolation from donor and recipient tissues associated with renal transplantation. Nature. 1978 Mar 23;272(5651):372–373. doi: 10.1038/272372a0. [DOI] [PubMed] [Google Scholar]
- Pass R. F. Epidemiology and transmission of cytomegalovirus. J Infect Dis. 1985 Aug;152(2):243–248. doi: 10.1093/infdis/152.2.243. [DOI] [PubMed] [Google Scholar]
- Pass R. F., Hutto C., Ricks R., Cloud G. A. Increased rate of cytomegalovirus infection among parents of children attending day-care centers. N Engl J Med. 1986 May 29;314(22):1414–1418. doi: 10.1056/NEJM198605293142204. [DOI] [PubMed] [Google Scholar]
- Pass R. F., Hutto S. C., Reynolds D. W., Polhill R. B. Increased frequency of cytomegalovirus infection in children in group day care. Pediatrics. 1984 Jul;74(1):121–126. [PubMed] [Google Scholar]
- Pass R. F., Little E. A., Stagno S., Britt W. J., Alford C. A. Young children as a probable source of maternal and congenital cytomegalovirus infection. N Engl J Med. 1987 May 28;316(22):1366–1370. doi: 10.1056/NEJM198705283162203. [DOI] [PubMed] [Google Scholar]
- Pass R. F., Long W. K., Whitley R. J., Soong S. J., Diethelm A. G., Reynolds D. W., Alford C. A., Jr Productive infection with cytomegalovirus and herpes simplex virus in renal transplant recipients: role of source of kidney. J Infect Dis. 1978 May;137(5):556–563. doi: 10.1093/infdis/137.5.556. [DOI] [PubMed] [Google Scholar]
- Pass R. F., Whitley R. J., Diethelm A. G., Whelchel J. D., Reynolds D. W., Alford C. A. Cytomegalovirus infection in patients with renal transplants: potentiation by antithymocyte globulin and an incompatible graft. J Infect Dis. 1980 Jul;142(1):9–17. doi: 10.1093/infdis/142.1.9. [DOI] [PubMed] [Google Scholar]
- Peckham C. S., Johnson C., Ades A., Pearl K., Chin K. S. Early acquisition of cytomegalovirus infection. Arch Dis Child. 1987 Aug;62(8):780–785. doi: 10.1136/adc.62.8.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perham T. G., Caul E. O., Conway P. J., Mott M. G. Cytomegalovirus infection in blood donors--a prospective study. Br J Haematol. 1971 Mar;20(3):307–320. doi: 10.1111/j.1365-2141.1971.tb07041.x. [DOI] [PubMed] [Google Scholar]
- Peterson P. K., Balfour H. H., Jr, Marker S. C., Fryd D. S., Howard R. J., Simmons R. L. Cytomegalovirus disease in renal allograft recipients: a prospective study of the clinical features, risk factors and impact on renal transplantation. Medicine (Baltimore) 1980 Jul;59(4):283–300. [PubMed] [Google Scholar]
- Plotkin S. A., Farquhar J., Horberger E. Clinical trials of immunization with the Towne 125 strain of human cytomegalovirus. J Infect Dis. 1976 Nov;134(5):470–475. doi: 10.1093/infdis/134.5.470. [DOI] [PubMed] [Google Scholar]
- Plotkin S. A., Furukawa T., Zygraich N., Huygelen C. Candidate cytomegalovirus strain for human vaccination. Infect Immun. 1975 Sep;12(3):521–527. doi: 10.1128/iai.12.3.521-527.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Plotkin S. A., Huang E. S. Cytomegalovirus vaccine virus (Towne strain) does not induce latency. J Infect Dis. 1985 Aug;152(2):395–397. doi: 10.1093/infdis/152.2.395. [DOI] [PubMed] [Google Scholar]
- Plotkin S. A., Smiley M. L., Friedman H. M., Starr S. E., Fleisher G. R., Wlodaver C., Dafoe D. C., Friedman A. D., Grossman R. A., Barker C. F. Towne-vaccine-induced prevention of cytomegalovirus disease after renal transplants. Lancet. 1984 Mar 10;1(8376):528–530. doi: 10.1016/s0140-6736(84)90930-9. [DOI] [PubMed] [Google Scholar]
- Preiksaitis J. K., Brown L., McKenzie M. Transfusion-acquired cytomegalovirus infection in neonates. A prospective study. Transfusion. 1988 May-Jun;28(3):205–209. doi: 10.1046/j.1537-2995.1988.28388219143.x. [DOI] [PubMed] [Google Scholar]
- Quinnan G. V., Jr, Delery M., Rook A. H., Frederick W. R., Epstein J. S., Manischewitz J. F., Jackson L., Ramsey K. M., Mittal K., Plotkin S. A. Comparative virulence and immunogenicity of the Towne strain and a nonattenuated strain of cytomegalovirus. Ann Intern Med. 1984 Oct;101(4):478–483. doi: 10.7326/0003-4819-101-4-478. [DOI] [PubMed] [Google Scholar]
- Rapp F., Geder L., Murasko D., Lausch R., Ladda R., Huang E. S., Webber M. M. Long-term persistence of cytomegalovirus genome in cultured human cells of prostatic origin. J Virol. 1975 Oct;16(4):982–990. doi: 10.1128/jvi.16.4.982-990.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reed E. C., Bowden R. A., Dandliker P. S., Gleaves C. A., Meyers J. D. Efficacy of cytomegalovirus immunoglobulin in marrow transplant recipients with cytomegalovirus pneumonia. J Infect Dis. 1987 Oct;156(4):641–645. doi: 10.1093/infdis/156.4.641. [DOI] [PubMed] [Google Scholar]
- Reed E. C., Bowden R. A., Dandliker P. S., Lilleby K. E., Meyers J. D. Treatment of cytomegalovirus pneumonia with ganciclovir and intravenous cytomegalovirus immunoglobulin in patients with bone marrow transplants. Ann Intern Med. 1988 Nov 15;109(10):783–788. doi: 10.7326/0003-4819-109-10-783. [DOI] [PubMed] [Google Scholar]
- Reed E. C., Meyers J. D. Treatment of cytomegalovirus infection. Clin Lab Med. 1987 Dec;7(4):831–852. [PubMed] [Google Scholar]
- Reynolds D. W., Stagno S., Hosty T. S., Tiller M., Alford C. A., Jr Maternal cytomegalovirus excretion and perinatal infection. N Engl J Med. 1973 Jul 5;289(1):1–5. doi: 10.1056/NEJM197307052890101. [DOI] [PubMed] [Google Scholar]
- Rice G. P., Schrier R. D., Oldstone M. B. Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to immediate-early gene products. Proc Natl Acad Sci U S A. 1984 Oct;81(19):6134–6138. doi: 10.1073/pnas.81.19.6134. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Richardson W. P., Colvin R. B., Cheeseman S. H., Tolkoff-Rubin N. E., Herrin J. T., Cosimi A. B., Collins A. B., Hirsch M. S., McCluskey R. T., Russell P. S. Glomerulopathy associated with cytomegalovirus viremia in renal allografts. N Engl J Med. 1981 Jul 9;305(2):57–63. doi: 10.1056/NEJM198107093050201. [DOI] [PubMed] [Google Scholar]
- Schrier R. D., Nelson J. A., Oldstone M. B. Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection. Science. 1985 Nov 29;230(4729):1048–1051. doi: 10.1126/science.2997930. [DOI] [PubMed] [Google Scholar]
- Schrier R. D., Oldstone M. B. Recent clinical isolates of cytomegalovirus suppress human cytomegalovirus-specific human leukocyte antigen-restricted cytotoxic T-lymphocyte activity. J Virol. 1986 Jul;59(1):127–131. doi: 10.1128/jvi.59.1.127-131.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schrier R. D., Rice G. P., Oldstone M. B. Suppression of natural killer cell activity and T cell proliferation by fresh isolates of human cytomegalovirus. J Infect Dis. 1986 Jun;153(6):1084–1091. doi: 10.1093/infdis/153.6.1084. [DOI] [PubMed] [Google Scholar]
- Skinner J., Finlay J. L., Sondel P. M., Trigg M. E. Infectious complications in pediatric patients undergoing transplantation with T lymphocyte-depleted bone marrow. Pediatr Infect Dis. 1986 May-Jun;5(3):319–324. doi: 10.1097/00006454-198605000-00009. [DOI] [PubMed] [Google Scholar]
- Smith J. D. Human cytomegalovirus: demonstration of permissive epithelial cells and nonpermissive fibroblastic cells in a survey of human cell lines. J Virol. 1986 Nov;60(2):583–588. doi: 10.1128/jvi.60.2.583-588.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Snydman D. R., Werner B. G., Heinze-Lacey B., Berardi V. P., Tilney N. L., Kirkman R. L., Milford E. L., Cho S. I., Bush H. L., Jr, Levey A. S. Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal-transplant recipients. N Engl J Med. 1987 Oct 22;317(17):1049–1054. doi: 10.1056/NEJM198710223171703. [DOI] [PubMed] [Google Scholar]
- Southern P., Oldstone M. B. Medical consequences of persistent viral infection. N Engl J Med. 1986 Feb 6;314(6):359–367. doi: 10.1056/NEJM198602063140606. [DOI] [PubMed] [Google Scholar]
- Spector D. H., Spector S. A. The oncogenic potential of human cytomegalovirus. Prog Med Virol. 1984;29:45–89. [PubMed] [Google Scholar]
- Spector S. A., Spector D. H. Molecular epidemiology of cytomegalovirus infections in premature twin infants and their mother. Pediatr Infect Dis. 1982 Nov-Dec;1(6):405–409. doi: 10.1097/00006454-198211000-00009. [DOI] [PubMed] [Google Scholar]
- Spector S. A. Transmission of cytomegalovirus among infants in hospital documented by restriction-endonuclease-digestion analyses. Lancet. 1983 Feb 19;1(8321):378–381. doi: 10.1016/s0140-6736(83)91499-x. [DOI] [PubMed] [Google Scholar]
- Stagno S., Pass R. F., Cloud G., Britt W. J., Henderson R. E., Walton P. D., Veren D. A., Page F., Alford C. A. Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcome. JAMA. 1986 Oct 10;256(14):1904–1908. [PubMed] [Google Scholar]
- Stagno S., Pass R. F., Dworsky M. E., Alford C. A., Jr Maternal cytomegalovirus infection and perinatal transmission. Clin Obstet Gynecol. 1982 Sep;25(3):563–576. doi: 10.1097/00003081-198209000-00014. [DOI] [PubMed] [Google Scholar]
- Stagno S., Pass R. F., Dworsky M. E., Henderson R. E., Moore E. G., Walton P. D., Alford C. A. Congenital cytomegalovirus infection: The relative importance of primary and recurrent maternal infection. N Engl J Med. 1982 Apr 22;306(16):945–949. doi: 10.1056/NEJM198204223061601. [DOI] [PubMed] [Google Scholar]
- Stagno S., Reynolds D., Tsiantos A., Fuccillo D. A., Smith R., Tiller M., Alford C. A., Jr Cervical cytomegalovirus excretion in pregnant and nonpregnant women: suppression in early gestation. J Infect Dis. 1975 May;131(5):522–527. doi: 10.1093/infdis/131.5.522. [DOI] [PubMed] [Google Scholar]
- Stinski M. F. The proteins of human cytomegalovirus. Birth Defects Orig Artic Ser. 1984;20(1):49–62. [PubMed] [Google Scholar]
- Stinski M. F., Thomsen D. R., Stenberg R. M., Goldstein L. C. Organization and expression of the immediate early genes of human cytomegalovirus. J Virol. 1983 Apr;46(1):1–14. doi: 10.1128/jvi.46.1.1-14.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Suwansirikul S., Rao N., Dowling J. N., Ho M. Primary and secondary cytomegalovirus infection. Arch Intern Med. 1977 Aug;137(8):1026–1029. [PubMed] [Google Scholar]
- Tanaka J., Ogura T., Kamiya S., Yoshie T., Yabuki Y., Hatano M. Dexamethasone enhances human cytomegalovirus replication in human epithelial cell cultures. Virology. 1984 Jul 30;136(2):448–452. doi: 10.1016/0042-6822(84)90182-x. [DOI] [PubMed] [Google Scholar]
- Taylor B. J., Jacobs R. F., Baker R. L., Moses E. B., McSwain B. E., Shulman G. Frozen deglycerolyzed blood prevents transfusion-acquired cytomegalovirus infections in neonates. Pediatr Infect Dis. 1986 Mar-Apr;5(2):188–191. doi: 10.1097/00006454-198603000-00005. [DOI] [PubMed] [Google Scholar]
- Tegtmeier G. E. Cytomegalovirus infection as a complication of blood transfusion. Semin Liver Dis. 1986 Feb;6(1):82–95. doi: 10.1055/s-2008-1040796. [DOI] [PubMed] [Google Scholar]
- Tegtmeier G. E. The use of cytomegalovirus-screened blood in neonates. Transfusion. 1988 May-Jun;28(3):201–203. doi: 10.1046/j.1537-2995.1988.28388219141.x. [DOI] [PubMed] [Google Scholar]
- Tolpin M. D., Stewart J. A., Warren D., Mojica B. A., Collins M. A., Doveikis S. A., Cabradilla C., Jr, Schauf V., Raju T. N., Nelson K. Transfusion transmission of cytomegalovirus confirmed by restriction endonuclease analysis. J Pediatr. 1985 Dec;107(6):953–956. doi: 10.1016/s0022-3476(85)80201-8. [DOI] [PubMed] [Google Scholar]
- Torfason E. G., Diderholm H. False RIA IgM titres to herpes simplex virus and cytomegalovirus: factors causing them, and their absorption by protein A-Sepharose/IgG-protein A-Sepharose. J Med Virol. 1982;10(3):157–170. doi: 10.1002/jmv.1890100302. [DOI] [PubMed] [Google Scholar]
- Turk S. R., Shipman C., Jr, Nassiri R., Genzlinger G., Krawczyk S. H., Townsend L. B., Drach J. C. Pyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirus. Antimicrob Agents Chemother. 1987 Apr;31(4):544–550. doi: 10.1128/aac.31.4.544. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tyms A. S., Scamans E. M., Naim H. M. The in vitro activity of acyclovir and related compounds against cytomegalovirus infections. J Antimicrob Chemother. 1981 Jul;8(1):65–72. doi: 10.1093/jac/8.1.65. [DOI] [PubMed] [Google Scholar]
- Walmsley S. L., Chew E., Read S. E., Vellend H., Salit I., Rachlis A., Fanning M. M. Treatment of cytomegalovirus retinitis with trisodium phosphonoformate hexahydrate (Foscarnet). J Infect Dis. 1988 Mar;157(3):569–572. doi: 10.1093/infdis/157.3.569. [DOI] [PubMed] [Google Scholar]
- Waner J. L., Weller T. H., Kevy S. V. Patterns of cytomegaloviral complement-fixing antibody activity: a longitudinal study of blood donors. J Infect Dis. 1973 May;127(5):538–543. doi: 10.1093/infdis/127.5.538. [DOI] [PubMed] [Google Scholar]
- Weller T. H. The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. II. N Engl J Med. 1971 Jul 29;285(5):267–274. doi: 10.1056/NEJM197107292850507. [DOI] [PubMed] [Google Scholar]
- Wentworth B. B., Alexander E. R. Seroepidemiology of infectious due to members of the herpesvirus group. Am J Epidemiol. 1971 Nov;94(5):496–507. doi: 10.1093/oxfordjournals.aje.a121347. [DOI] [PubMed] [Google Scholar]
- Wertheim P., Galama J., Geelen J., Buurman C., van der Noordaa J. Epidemiology of infections with cytomegalovirus (CMV) and herpes simplex virus in promiscuous women: absence of exogenous reinfection with CMV. Genitourin Med. 1985 Dec;61(6):383–386. doi: 10.1136/sti.61.6.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whitley R. J. Ganciclovir--have we established clinical value in the treatment of cytomegalovirus infections? Ann Intern Med. 1988 Mar;108(3):452–454. doi: 10.7326/0003-4819-108-3-452. [DOI] [PubMed] [Google Scholar]
- Wilhelm J. A., Matter L., Schopfer K. The risk of transmitting cytomegalovirus to patients receiving blood transfusions. J Infect Dis. 1986 Jul;154(1):169–171. doi: 10.1093/infdis/154.1.169. [DOI] [PubMed] [Google Scholar]
- Yeager A. S., Grumet F. C., Hafleigh E. B., Arvin A. M., Bradley J. S., Prober C. G. Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J Pediatr. 1981 Feb;98(2):281–287. doi: 10.1016/s0022-3476(81)80662-2. [DOI] [PubMed] [Google Scholar]
- Yow M. D., Lakeman A. D., Stagno S., Reynolds R. B., Plavidal F. J. Use of restriction enzymes to investigate the source of a primary cytomegalovirus infection in a pediatric nurse. Pediatrics. 1982 Nov;70(5):713–716. [PubMed] [Google Scholar]
- el-Beik T., Razzaque A., Jariwalla R., Cihlar R. L., Rosenthal L. J. Multiple transforming regions of human cytomegalovirus DNA. J Virol. 1986 Nov;60(2):645–652. doi: 10.1128/jvi.60.2.645-652.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]