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. 1990 Jul;3(3):247–268. doi: 10.1128/cmr.3.3.247

Serology of coccidioidomycosis.

D Pappagianis 1, B L Zimmer 1
PMCID: PMC358158  PMID: 2200605

Abstract

Serologic tests have assisted in the diagnosis and prognosis of coccidioidomycosis for a half-century. The causative agent, Coccidioides immitis, is a dimorphic fungus existing in a hyphal form with arthroconidia in nature and in the usual culture. The arthroconidia represent the inhaled infective forms which in vivo and under special laboratory conditions form spherules which endosporulate. The culture filtrate/autolysate (coccidioidin) from the hyphal phase has provided antigens of suitable reliability for currently used serologic tests. These tests are primarily to determine the two major antibody responses: the early immunoglobulin M (IgM) response is useful in the diagnosis of acute primary coccidioidomycosis. Later, IgG is produced and usually outlasts the IgM, persisting in chronic coccidioidomycosis. The IgM is detectable by tube precipitin, a corresponding immunodiffusion, or latex particle agglutination tests. The pertinent antigen(s) is heat stable and pronase resistant and appears to be largely carbohydrate, mainly mannose with some 3-O-methyl mannose. The IgG detectable in the serum and other body fluids by complement fixation and a corresponding immuno-diffusion is useful in diagnosis, and its quantitation provides an indicator of progression of disease (increasing titer) or regression (decreasing titer). The pertinent antigen appears to be a heat-labile, pronase-sensitive protein which in an unreduced form has a molecular weight of 110,000. A third very useful serologic procedure is the exoantigen test for identification of putative cultures of C. immitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AJELLO L., WALLS K., MOORE J. C., FALCONE R. Rapid production of complement fixation antigens for systemic mycotic diseases. I. Coccidioidin: influence of media and mechanical agitation on its development. J Bacteriol. 1959 Jun;77(6):753–756. doi: 10.1128/jb.77.6.753-756.1959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aguilar-Torres F. G., Jackson L. J., Ferstenfeld J. E., Pappagianis D., Rytel M. W. Counterimmunoelectrophoresis in the detection of antibodies against Coccidioides immitis. Ann Intern Med. 1976 Dec;85(6):740–744. doi: 10.7326/0003-4819-85-6-740. [DOI] [PubMed] [Google Scholar]
  3. BIEBERDORF F. W., CHAMBLISS K. W. A positive control for coccidioidin complement fixation. Public Health Rep. 1955 Aug;70(8):771–774. [PMC free article] [PubMed] [Google Scholar]
  4. Blumenkranz M. S., Stevens D. A. Endogenous coccidioidal endophthalmitis. Ophthalmology. 1980 Oct;87(10):974–984. doi: 10.1016/s0161-6420(80)35137-3. [DOI] [PubMed] [Google Scholar]
  5. Brewer J. H., Parrott C. L., Rimland D. Disseminated coccidioidomycosis in a heart transplant recipient. Sabouraudia. 1982 Dec;20(4):261–265. doi: 10.1080/00362178285380381. [DOI] [PubMed] [Google Scholar]
  6. CAMPBELL C. C., BINKLEY G. E. Serologic diagnosis with respect to histoplasmosis, coccidioidomycosis, and blastomycosis and the problem of cross reactions. J Lab Clin Med. 1953 Dec;42(6):896–906. [PubMed] [Google Scholar]
  7. CAMPBELL C. C. The accuracy of serologic methods in diagnosis. Ann N Y Acad Sci. 1960 Aug 27;89:163–177. doi: 10.1111/j.1749-6632.1960.tb20139.x. [DOI] [PubMed] [Google Scholar]
  8. CHAPMAN J. S. Mycobacterial and mycotic antibodies in sera of patients with sarcoidosis. Results of studies using agar double-diffusion technique. Ann Intern Med. 1961 Dec;55:918–924. doi: 10.7326/0003-4819-55-6-918. [DOI] [PubMed] [Google Scholar]
  9. CONVERSE J. L. Effect of surface active agents on endosporulation of Coccidioides immitis in a chemically defined medium. J Bacteriol. 1957 Jul;74(1):106–107. doi: 10.1128/jb.74.1.106-107.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Calhoun D. L., Osir E. O., Dugger K. O., Galgiani J. N., Law J. H. Humoral antibody responses to specific antigens of Coccidioides immitis. J Infect Dis. 1986 Aug;154(2):265–272. doi: 10.1093/infdis/154.2.265. [DOI] [PubMed] [Google Scholar]
  11. Campbell C. C. Use and interpretation of serologic and skin tests in the respiratory mycoses: current considerations. Dis Chest. 1968 Oct;54(Suppl):305+–305+. doi: 10.1378/chest.54.supplement_1.305. [DOI] [PubMed] [Google Scholar]
  12. Candy D. J., Baddiley J. 3-O-methyl-D-mannose from Streptomyces griseus. Biochem J. 1966 Jan;98(1):15–18. doi: 10.1042/bj0980015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Catanzaro A., Flatauer F. Detection of serum antibodies in coccidioidomycosis by solid-phase radioimmunoassay. J Infect Dis. 1983 Jan;147(1):32–39. doi: 10.1093/infdis/147.1.32. [DOI] [PubMed] [Google Scholar]
  14. Chaparas S. T., Kaufman L., Kim S. J., McLaughlin D. W. Characterization of antigens from Aspergillus fumigatus. V. Reactivity in immunodiffusion tests with serums from patients with aspergillosis caused by Aspergillus flavus, A. niger, and A fumigatus. Am Rev Respir Dis. 1980 Oct;122(4):647–650. doi: 10.1164/arrd.1980.122.4.647. [DOI] [PubMed] [Google Scholar]
  15. Cohen I. M., Galgiani J. N., Potter D., Ogden D. A. Coccidioidomycosis in renal replacement therapy. Arch Intern Med. 1982 Mar;142(3):489–494. [PubMed] [Google Scholar]
  16. Cole G. T., Kirkland T. N., Franco M., Zhu S., Yuan L., Sun S. H., Hearn V. M. Immunoreactivity of a surface wall fraction produced by spherules of Coccidioides immitis. Infect Immun. 1988 Oct;56(10):2695–2701. doi: 10.1128/iai.56.10.2695-2701.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Cole G. T., Seshan K. R., Franco M., Bukownik E., Sun S. H., Hearn V. M. Isolation and morphology of an immunoreactive outer wall fraction produced by spherules of Coccidioides immitis. Infect Immun. 1988 Oct;56(10):2686–2694. doi: 10.1128/iai.56.10.2686-2694.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Cole G. T., Zhu S. W., Pan S. C., Yuan L., Kruse D., Sun S. H. Isolation of antigens with proteolytic activity from Coccidioides immitis. Infect Immun. 1989 May;57(5):1524–1534. doi: 10.1128/iai.57.5.1524-1534.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Cox R. A., Baker B. S., Stevens D. A. Specificity of immunoglobulin E in coccidioidomycosis and correlation with disease involvement. Infect Immun. 1982 Aug;37(2):609–616. doi: 10.1128/iai.37.2.609-616.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Cox R. A., Britt L. A. Antigenic identity of biologically active antigens in coccidioidin and spherulin. Infect Immun. 1987 Nov;55(11):2590–2596. doi: 10.1128/iai.55.11.2590-2596.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Cox R. A., Britt L. A. Isolation of a coccidioidin component that reacts with immunoglobulin M precipitin antibody. Infect Immun. 1986 Sep;53(3):449–453. doi: 10.1128/iai.53.3.449-453.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Cox R. A., Britt L. A., Michael R. A. Isolation of Coccidioides immitis F antigen by immunoaffinity chromatography with monospecific antiserum. Infect Immun. 1987 Jan;55(1):227–232. doi: 10.1128/iai.55.1.227-232.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Cox R. A., Huppert M., Starr P., Britt L. A. Reactivity of alkali-soluble, water-soluble cell wall antigen of Coccidioides immitis with anti-Coccidioides immunoglobulin M precipitin antibody. Infect Immun. 1984 Feb;43(2):502–507. doi: 10.1128/iai.43.2.502-507.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. DeMartini J. C., Riddle W. E. Disseminated coccidioidomycosis in two horses and a pony. J Am Vet Med Assoc. 1969 Jul 15;155(2):149–156. [PubMed] [Google Scholar]
  25. Deresinski S. C., Levine H. B., Kelly P. C., Creasman R. J., Stevens D. A. Spherulin skin testing and histoplasmal and coccidioidal serology: lack of effect. Am Rev Respir Dis. 1977 Dec;116(6):1116–1118. doi: 10.1164/arrd.1977.116.6.1116. [DOI] [PubMed] [Google Scholar]
  26. Deresinski S. C., Stevens D. A. Coccidioidomycosis in compromised hosts. Experience at Stanford University Hospital. Medicine (Baltimore) 1975 Sep;54(5):377–395. doi: 10.1097/00005792-197509000-00002. [DOI] [PubMed] [Google Scholar]
  27. DiSalvo A. F., Terreni A. A., Wooten A. K. Use of the exoantigen test to identify blastomyces dermatitidis, coccidioides immitis, and Histoplasma capsulatum in mixed cultures. Am J Clin Pathol. 1981 Jun;75(6):825–826. doi: 10.1093/ajcp/75.6.825. [DOI] [PubMed] [Google Scholar]
  28. Dolan M. J., Cox R. A., Williams V., Woolley S. Development and characterization of a monoclonal antibody against the tube precipitin antigen of Coccidioides immitis. Infect Immun. 1989 Apr;57(4):1035–1039. doi: 10.1128/iai.57.4.1035-1039.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Galgiani J. N., Dugger K. O., Ampel N. M., Sun S. H., Law J. H. Extraction of serologic and delayed hypersensitivity antigens from spherules of Coccidioides immitis. Diagn Microbiol Infect Dis. 1988 Oct;11(2):65–80. doi: 10.1016/0732-8893(88)90075-2. [DOI] [PubMed] [Google Scholar]
  30. Galgiani J. N., Dugger K. O., Ito J. I., Wieden M. A. Antigenemia in primary coccidioidomycosis. Am J Trop Med Hyg. 1984 Jul;33(4):645–649. doi: 10.4269/ajtmh.1984.33.645. [DOI] [PubMed] [Google Scholar]
  31. Galgiani J. N., Hayden R., Payne C. M. Leukocyte effects on the dimorphism of Coccidioides immitis. J Infect Dis. 1982 Jul;146(1):56–63. doi: 10.1093/infdis/146.1.56. [DOI] [PubMed] [Google Scholar]
  32. Gamble C. N., Ruggles S. W. The immunopathogenesis of glomerulonephritis associated with mixed cryoglobulinemia. N Engl J Med. 1978 Jul 13;299(2):81–84. doi: 10.1056/NEJM197807132990206. [DOI] [PubMed] [Google Scholar]
  33. Goldstein E., Winship M. J., Pappagianis D. Ventricular fluid and the management of coccidioidal meningitis. Ann Intern Med. 1972 Aug;77(2):243–246. doi: 10.7326/0003-4819-77-2-243. [DOI] [PubMed] [Google Scholar]
  34. Graham A. R., Ryan K. J. Counterimmunoelectrophoresis employing coccidioidin in serologic testing for coccidioidomycosis. Am J Clin Pathol. 1980 Apr;73(4):574–577. doi: 10.1093/ajcp/73.4.574. [DOI] [PubMed] [Google Scholar]
  35. HEINER D. C. Diagnosis of histoplasmosis using precipitin reactions in agargel. Pediatrics. 1958 Oct;22(4 Pt 1):616–627. [PubMed] [Google Scholar]
  36. HUGENHOLTZ P. G., REED R. E., MADDY K. T., TRAUTMAN R. J., BARGER J. D. Experimental coccidioidomycosis in dogs. Am J Vet Res. 1958 Apr;19(71):433–437. [PubMed] [Google Scholar]
  37. Huppert M., Adler J. P., Rice E. H., Sun S. H. Common antigens among systemic disease fungi analyzed by two-dimensional immunoelectrophoresis. Infect Immun. 1979 Feb;23(2):479–485. doi: 10.1128/iai.23.2.479-485.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Huppert M., Chitjian P. A., Gross A. J. Comparison of methods for coccidioidomycosis complement fixation. Appl Microbiol. 1970 Sep;20(3):328–332. doi: 10.1128/am.20.3.328-332.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Huppert M., Krasnow I., Vukovich K. R., Sun S. H., Rice E. H., Kutner L. J. Comparison of coccidioidin and spherulin in complement fixation tests for coccidioidomycosis. J Clin Microbiol. 1977 Jul;6(1):33–41. doi: 10.1128/jcm.6.1.33-41.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Huppert M., Peterson E. T., Sun S. H., Chitjian P. A., Derrevere W. J. Evaluation of a latex particle agglutination test for coccidioidomycosis. Am J Clin Pathol. 1968 Jan;49(1):96–102. doi: 10.1093/ajcp/49.1.96. [DOI] [PubMed] [Google Scholar]
  41. Huppert M. Serology of coccidioidomycosis. Mycopathol Mycol Appl. 1970;41(1):107–113. doi: 10.1007/BF02051487. [DOI] [PubMed] [Google Scholar]
  42. Huppert M., Spratt N. S., Vukovich K. R., Sun S. H., Rice E. H. Antigenic analysis of coccidioidin and spherulin determined by two-dimensional immunoelectrophoresis. Infect Immun. 1978 May;20(2):541–551. doi: 10.1128/iai.20.2.541-551.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Huppert M., Sun S. H., Rice E. H. Specificity of exoantigens for identifying cultures of Coccidioides immitis. J Clin Microbiol. 1978 Sep;8(3):346–348. doi: 10.1128/jcm.8.3.346-348.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Hurwitz S., Young J. E., Eddie B. U. Coccidioides Immitis Intradermal Skin Reaction: A Preliminary Report of 449 Cases. Cal West Med. 1938 Feb;48(2):87–89. [PMC free article] [PubMed] [Google Scholar]
  45. Jensen T. D., Schønheyder H., Andersen P., Stenderup A. Binding of C-reactive protein to Aspergillus fumigatus fractions. J Med Microbiol. 1986 Mar;21(2):173–177. doi: 10.1099/00222615-21-2-173. [DOI] [PubMed] [Google Scholar]
  46. Johnson J. E., DeRemee R. A., Kueppers F., Roberts G. D. Prevalence of fungal complement-fixing antibodies in sarcoidosis. Am Rev Respir Dis. 1977 Jul;116(1):145–147. doi: 10.1164/arrd.1977.116.1.145. [DOI] [PubMed] [Google Scholar]
  47. KAPLAN W., CLIFFORD M. K. PRODUCTION OF FLUORESCENT ANTIBODY REAGENTS SPECIFIC FOR THE TISSUE FORM OF COCCIDIOIDES IMMITIS. Am Rev Respir Dis. 1964 May;89:651–658. doi: 10.1164/arrd.1964.89.5.651. [DOI] [PubMed] [Google Scholar]
  48. KONG Y. C., LEVINE H. B., SMITH C. E. Immunogenic properties of nondisrupted and disrupted spherules of Coccidioides immitis in mice. Sabouraudia. 1963 Feb;2:131–142. [PubMed] [Google Scholar]
  49. Kaplan W. Direct fluorescent antibody tests for the diagnosis of mycotic diseases. Ann Clin Lab Sci. 1973 Jan-Feb;3(1):25–29. [PubMed] [Google Scholar]
  50. Kaplan W., Huppert M., Kraft D. E., Bailey J. Fluorescent antibody inhibition test for Coccidioides immitis antibodies. Sabouraudia. 1966 Jun;5(1):1–6. [PubMed] [Google Scholar]
  51. Kaufman L., Clark M. J. Value of the concomitant use of complement fixation and immunodiffusion tests in the diagnosis of coccidioidomycosis. Appl Microbiol. 1974 Oct;28(4):641–643. doi: 10.1128/am.28.4.641-643.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Kaufman L., Standard P. G., Huppert M., Pappagianis D. Comparison and diagnostic value of the coccidioidin heat-stable (HS and tube precipitin) antigens in immunodiffusion. J Clin Microbiol. 1985 Oct;22(4):515–518. doi: 10.1128/jcm.22.4.515-518.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Kaufman L., Standard P. Improved version of the exoantigen test for identification of Coccidioides immitis and Histoplasma capsulatum cultures. J Clin Microbiol. 1978 Jul;8(1):42–45. doi: 10.1128/jcm.8.1.42-45.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Klotz S. A., Drutz D. J., Huppert M., Sun S. H., DeMarsh P. L. The critical role of CO2 in the morphogenesis of Coccidioides immitis in cell-free subcutaneous chambers. J Infect Dis. 1984 Jul;150(1):127–134. doi: 10.1093/infdis/150.1.127. [DOI] [PubMed] [Google Scholar]
  55. Kruse D., Cole G. T. Isolation of tube precipitin antibody-reactive fractions of Coccidioides immitis. Infect Immun. 1990 Jan;58(1):169–178. doi: 10.1128/iai.58.1.169-178.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. LEVINE H. B., COBB J. M., SMITH C. E. Immunity to coccidioi-domycosis induced in mice by purified spherule, arthrospore, and mycelial vaccines. Trans N Y Acad Sci. 1960 Apr;22:436–449. doi: 10.1111/j.2164-0947.1960.tb00711.x. [DOI] [PubMed] [Google Scholar]
  57. LEVINE H. B., MILLER R. L., SMITH C. E. Influence of vaccination on respiratory coccidiodial disease in cynomolgous monkeys. J Immunol. 1962 Aug;89:242–251. [PubMed] [Google Scholar]
  58. LONGBOTTOM J. L., PEPYS J. PULMONARY ASPERGILLOSIS: DIAGNOSTIC AND IMMUNOLOGICAL SIGNIFICANCE OF ANTIGENS AND C-SUBSTANCE IN ASPERGILLUS FUMIGATUS. J Pathol Bacteriol. 1964 Jul;88:141–151. doi: 10.1002/path.1700880119. [DOI] [PubMed] [Google Scholar]
  59. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  60. Landay M. E., Wheat R. W., Conant N. F., Lowe E. P. Serological comparison of the three morphological phases of Coccidioides immitis by the agar gel diffusion method. J Bacteriol. 1967 Jan;93(1):1–6. doi: 10.1128/jb.93.1.1-6.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Levine H. B., Cobb J. M., Scalarone G. M. Spherule coccidioidin in delayed dermal sensitivity reactions of experimental animals. Sabouraudia. 1969 Feb;7(1):20–32. doi: 10.1080/00362177085190051. [DOI] [PubMed] [Google Scholar]
  62. Levine H. B., Pappagianis D., Cobb J. M. Development of vaccines for coccidioidomycosis. Mycopathol Mycol Appl. 1970;41(1):177–185. doi: 10.1007/BF02051493. [DOI] [PubMed] [Google Scholar]
  63. Lombard C. M., Tazelaar H. D., Krasne D. L. Pulmonary eosinophilia in coccidioidal infections. Chest. 1987 May;91(5):734–736. doi: 10.1378/chest.91.5.734. [DOI] [PubMed] [Google Scholar]
  64. Meyer P. R., Hui A. N., Biddle M. Coccidioides immitis meningitis with arthroconidia in cerebrospinal fluid: report of the first case and review of the arthroconidia literature. Hum Pathol. 1982 Dec;13(12):1136–1138. doi: 10.1016/s0046-8177(82)80253-0. [DOI] [PubMed] [Google Scholar]
  65. Miller M. J., Sunshine P. J., Remington J. S. Quantitation of cord serum IgM and IgA as a screening procedure to detect congenital infection: results in 5,006 infants. J Pediatr. 1969 Dec;75(6):1287–1291. doi: 10.1016/s0022-3476(69)80385-9. [DOI] [PubMed] [Google Scholar]
  66. Muir S., Pappagianis D. Coccidioidomycosis in the llama: case report and epidemiologic survey. J Am Vet Med Assoc. 1982 Dec 1;181(11):1334–1337. [PubMed] [Google Scholar]
  67. Nimmich W. Occurrence of 3-O-methylmannose in lipopolysaccharides of Klebsiella and Escherichia coli. Biochim Biophys Acta. 1970 Jul 21;215(1):189–191. doi: 10.1016/0304-4165(70)90403-4. [DOI] [PubMed] [Google Scholar]
  68. PAPPAGIANIS D., KOBAYASHI G. S. Approaches to the physiology of Coccidioides immitis. Ann N Y Acad Sci. 1960 Aug 27;89:109–121. doi: 10.1111/j.1749-6632.1960.tb20135.x. [DOI] [PubMed] [Google Scholar]
  69. PAPPAGIANIS D., LINDSEY N. J., SMITH C. E., SAITO M. T. ANTIBODIES IN HUMAN COCCIDIOIDOMYCOSIS: IMMUNOELECTROPHORETIC PROPERTIES. Proc Soc Exp Biol Med. 1965 Jan;118:118–122. doi: 10.3181/00379727-118-29773. [DOI] [PubMed] [Google Scholar]
  70. PAPPAGIANIS D., MILLER R. L., SMITH C. E., KOBAYASHI G. S. Response of monkeys to respiratory challenge following subcutaneous inoculation with Coccidioides immitis. Am Rev Respir Dis. 1960 Aug;82:244–250. doi: 10.1164/arrd.1960.82.2.244. [DOI] [PubMed] [Google Scholar]
  71. PAPPAGIANIS D., PUTMAN E. W., KOBAYASHI G. S. Polysaccharide of Coccidioides immitis. J Bacteriol. 1961 Nov;82:714–723. doi: 10.1128/jb.82.5.714-723.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. PAPPAGIANIS D., SMITH C. E., KOBAYASHI G. S., SAITO M. T. Studies of antigens from young mycelia of Coccidioides immitis. J Infect Dis. 1961 Jan-Feb;108:35–44. doi: 10.1093/infdis/108.1.35. [DOI] [PubMed] [Google Scholar]
  73. Pappagianis D., Einstein H. Tempest from Tehachapi takes toll or Coccidioides conveyed aloft and afar. West J Med. 1978 Dec;129(6):527–530. [PMC free article] [PubMed] [Google Scholar]
  74. Pappagianis D., Krasnow R. I., Beall S. False-positive reactions of cerebrospinal fluid and diluted sera with the coccidioidal latex-agglutination test. Am J Clin Pathol. 1976 Nov;66(5):916–921. doi: 10.1093/ajcp/66.5.916. [DOI] [PubMed] [Google Scholar]
  75. Pappagianis D., Lindsay S., Beall S., Williams P. Ethnic background and the clinical course of coccidioidomycosis. Am Rev Respir Dis. 1979 Oct;120(4):959–961. doi: 10.1164/arrd.1979.120.4.959. [DOI] [PubMed] [Google Scholar]
  76. Pappagianis D., Saito M., Van Hoosear K. H. Antibody in cerebrospinal fluid in non-meningitic coccidioidomycosis. Sabouraudia. 1972 Jul;10(2):173–179. doi: 10.1080/00362177285190341. [DOI] [PubMed] [Google Scholar]
  77. Pappagianis D., Smith C. E., Campbell C. C. Serologic status after positive coccidioidin skin reactions. Am Rev Respir Dis. 1967 Sep;96(3):520–523. doi: 10.1164/arrd.1967.96.3.520. [DOI] [PubMed] [Google Scholar]
  78. Pepys J., Longbottom J. L. Antigenic and C-substance activities of related glycopeptides from fungal, parasitic and vegetable sources. Int Arch Allergy Appl Immunol. 1971;41(1):219–221. doi: 10.1159/000230520. [DOI] [PubMed] [Google Scholar]
  79. Petersen E. A., Friedman B. A., Crowder E. D., Rifkind D. Coccidoidouria: clinical significance. Ann Intern Med. 1976 Jul;85(1):34–38. doi: 10.7326/0003-4819-85-1-34. [DOI] [PubMed] [Google Scholar]
  80. Porter J. F., Scheer E. R., Wheat R. W. Characterization of 3-O-methylmannose from Coccidioides immitis. Infect Immun. 1971 Nov;4(5):660–661. doi: 10.1128/iai.4.5.660-661.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. REED R. E. Diagnosis of disseminated canine coccidioidomycosis. J Am Vet Med Assoc. 1956 Feb 15;128(4):196–201. [PubMed] [Google Scholar]
  82. ROWE J. R., NEWCOMER V. D., LANDAU J. W. EFFECTS OF CULTURAL CONDITIONS ON THE DEVELOPMENT OF ANTIGENS BY COCCIDIOIDES IMMITIS. J Invest Dermatol. 1963 Nov;41:343–350. doi: 10.1038/jid.1963.120. [DOI] [PubMed] [Google Scholar]
  83. ROWE J. R., NEWCOMER V. D., WRIGHT E. T. STUDIES OF THE SOLUBLE ANTIGENS OF COCCIDIOIDES IMMITIS BY IMMUNODIFFUSION. J Invest Dermatol. 1963 Oct;41:225–233. doi: 10.1038/jid.1963.100. [DOI] [PubMed] [Google Scholar]
  84. Resnick S., Pappagianis D., McKerrow J. H. Proteinase production by the parasitic cycle of the pathogenic fungus Coccidioides immitis. Infect Immun. 1987 Nov;55(11):2807–2815. doi: 10.1128/iai.55.11.2807-2815.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. SALVIN S. B., FURCOLOW M. L., NISHIO J. Serologic studies on outbreak of pulmonary disease at Camp Gruber, okla. AMA Arch Intern Med. 1954 Jun;93(6):906–910. doi: 10.1001/archinte.1954.00240300100010. [DOI] [PubMed] [Google Scholar]
  86. SCHUBERT J. H., HAMPSON C. R. An appraisal of serologic tests for coccidioidomycosis. Am J Hyg. 1962 Sep;76:144–148. doi: 10.1093/oxfordjournals.aje.a120269. [DOI] [PubMed] [Google Scholar]
  87. SMITH C. E., SAITO M. T., BEARD R. R., KEPP R. M., CLARK R. W., EDDIE B. U. Serological tests in the diagnosis and prognosis of coccidioidomycosis. Am J Hyg. 1950 Jul;52(1):1–21. doi: 10.1093/oxfordjournals.aje.a119404. [DOI] [PubMed] [Google Scholar]
  88. SMITH C. E., SAITO M. T., CAMPBELL C. C., HILL G. B., SASLAW S., SALVIN S. B., FENTON J. E., KRUPP M. A. Comparison of complement fixation tests for coccidioidomycosis. Public Health Rep. 1957 Oct;72(10):888–894. [PMC free article] [PubMed] [Google Scholar]
  89. SMITH C. E., SAITO M. T., SIMONS S. A. Pattern of 39,500 serologic tests in coccidioidomycosis. J Am Med Assoc. 1956 Feb 18;160(7):546–552. doi: 10.1001/jama.1956.02960420026008. [DOI] [PubMed] [Google Scholar]
  90. Sawaki Y., Huppert M., Bailey J. W., Yagi Y. Patterns of human antibody reactions in coccidioidomycosis. J Bacteriol. 1966 Jan;91(1):422–427. doi: 10.1128/jb.91.1.422-427.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Scalarone G. M., Levine H. B., Chaparas S. D., Cobb J. M. Properties and assay of spherulins from Coccidioides immitis in delayed sensitivity responses of animals. Sabouraudia. 1973 Nov;11(3):222–234. [PubMed] [Google Scholar]
  92. Scalarone G. M., Levine H. B., Pappagianis D., Chaparas S. D. Spherulin as a complement-fixing antigen in human coccidioidomycosis. Am Rev Respir Dis. 1974 Sep;110(3):324–328. doi: 10.1164/arrd.1974.110.3.324. [DOI] [PubMed] [Google Scholar]
  93. Scheer E., Terai T., Kulkarni S., Conant N. F., Wheat R. W., Lowe E. P. Unusual reducing sugar from Coccidioides immitis. J Bacteriol. 1970 Aug;103(2):525–526. doi: 10.1128/jb.103.2.525-526.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Sinski J. T., Lowe E. P., Castleberry M. W., Maire L. F., 3rd, Del Favero J. E., Pakes S. P., Converse J. L. Comparison of serologic reactions in experimental canine and simian coccidioidomycosis. Sabouraudia. 1963 Oct;3(1):106–113. doi: 10.1080/00362176485190151. [DOI] [PubMed] [Google Scholar]
  95. Standard P. G., Kaufman L. Immunological procedure for the rapid and specific identification of Coccidioides immitis cultures. J Clin Microbiol. 1977 Feb;5(2):149–153. doi: 10.1128/jcm.5.2.149-153.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Taylor R. L. Serological response of rhesus monkeys to histoplasma, Blastomyces, and Coccidioides antigens. J Bacteriol. 1967 Jul;94(1):1–5. doi: 10.1128/jb.94.1.1-5.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Teel K. W., Yow M. D., Williams T. W., Jr A localized outbreak of coccidioidomycosis in southern Texas. J Pediatr. 1970 Jul;77(1):65–73. doi: 10.1016/s0022-3476(70)80046-4. [DOI] [PubMed] [Google Scholar]
  98. Wack E. E., Dugger K. O., Galgiani J. N. Enzyme-linked immunosorbent assay for antigens of Coccidioides immitis: human sera interference corrected by acidification-heat extraction. J Lab Clin Med. 1988 May;111(5):560–565. [PubMed] [Google Scholar]
  99. Weiner M. H. Antigenemia detected in human coccidioidomycosis. J Clin Microbiol. 1983 Jul;18(1):136–142. doi: 10.1128/jcm.18.1.136-142.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Weisman I. M., Moreno A. J., Parker A. L., Sippo W. C., Liles W. J. Gastrointestinal dissemination of coccidioidomycosis. Am J Gastroenterol. 1986 Jul;81(7):589–593. [PubMed] [Google Scholar]
  101. Wheat R. W., Tritschler C., Conant N. F., Lowe E. P. Comparison of Coccidioides immitis arthrospore, mycelium, and spherule cell walls, and influence of growth medium on mycelial cell wall composition. Infect Immun. 1977 Jul;17(1):91–97. doi: 10.1128/iai.17.1.91-97.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Wieden M. A., Galgiani J. N., Pappagianis D. Comparison of immunodiffusion techniques with standard complement fixation assay for quantitation of coccidioidal antibodies. J Clin Microbiol. 1983 Sep;18(3):529–534. doi: 10.1128/jcm.18.3.529-534.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  103. Wolf J. E., Little J. R., Pappagianis D., Kobayashi G. S. Disseminated coccidioidomycosis in a patient with the acquired immune deficiency syndrome. Diagn Microbiol Infect Dis. 1986 Nov;5(4):331–336. doi: 10.1016/0732-8893(86)90038-6. [DOI] [PubMed] [Google Scholar]
  104. Wood J. C., Friedly G., Zartarian M., Aarnaes S., de la Maza L. M. Alternatives to the standardized laboratory branch complement fixation test for detection of antibodies to Coccidioides immitis. J Clin Microbiol. 1982 Dec;16(6):1030–1033. doi: 10.1128/jcm.16.6.1030-1033.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Yoshinoya S., Cox R. A., Pope R. M. Circulating immune complexes in coccidioidomycosis. Detection and characterization. J Clin Invest. 1980 Oct;66(4):655–663. doi: 10.1172/JCI109901. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Yturraspe D. J. Clinical evaluation of a latex particle agglutination test and a gel diffusion precipitin test in the diagnosis of canine coccidioidomycosis. J Am Vet Med Assoc. 1971 Apr 1;158(7):1249–1256. [PubMed] [Google Scholar]
  107. Zimmer B. L., Pappagianis D. Characterization of a soluble protein of Coccidiodes immitis with activity as an immunodiffusion-complement fixation antigen. J Clin Microbiol. 1988 Nov;26(11):2250–2256. doi: 10.1128/jcm.26.11.2250-2256.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Zimmer B. L., Pappagianis D. Comparison of immunoblot analyses of spherule-endospore-phase extracellular protein and mycelial-phase antigen of Coccidioides immitis. Infect Immun. 1986 Jul;53(1):64–70. doi: 10.1128/iai.53.1.64-70.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Zimmer B. L., Pappagianis D. Immunoaffinity isolation and partial characterization of the Coccidioides immitis antigen detected by the tube precipitin and immunodiffusion-tube precipitin tests. J Clin Microbiol. 1989 Aug;27(8):1759–1766. doi: 10.1128/jcm.27.8.1759-1766.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]

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