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. 1990 Oct;3(4):376–396. doi: 10.1128/cmr.3.4.376

The dengue viruses.

E A Henchal 1, J R Putnak 1
PMCID: PMC358169  PMID: 2224837

Abstract

Dengue, a major public health problem throughout subtropical and tropical regions, is an acute infectious disease characterized by biphasic fever, headache, pain in various parts of the body, prostration, rash, lymphadenopathy, and leukopenia. In more severe or complicated dengue, patients present with a severe febrile illness characterized by abnormalities of hemostasis and increased vascular permeability, which in some instances results in a hypovolemic shock. Four distinct serotypes of the dengue virus (dengue-1, dengue-2, dengue-3, and dengue-4) exist, with numerous virus strains found worldwide. Molecular cloning methods have led to a greater understanding of the structure of the RNA genome and definition of virus-specific structural and nonstructural proteins. Progress towards producing safe, effective dengue virus vaccines, a goal for over 45 years, has been made.

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Selected References

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  1. Aaskov J. G., Geysen H. M., Mason T. J. Serologically defined linear epitopes in the envelope protein of dengue 2 (Jamaica strain 1409). Arch Virol. 1989;105(3-4):209–221. doi: 10.1007/BF01311358. [DOI] [PubMed] [Google Scholar]
  2. Angsubhakorn S., Moe J. B., Latendresse J. R., Ward G. S., Ngamprochana M., Sahaphong S., Bhamarapravati N. The neurovirulence of flaviviruses in crab-eating monkeys (Macaca fascicularis). Southeast Asian J Trop Med Public Health. 1986 Dec;17(4):604–612. [PubMed] [Google Scholar]
  3. Angsubhakorn S., Moe J. B., Marchette N. J., Latendresse J. R., Palumbo N. E., Yoksan S., Bhamarapravati N. Neurovirulence detection of dengue virus using rhesus and cynomolgus monkeys. J Virol Methods. 1987 Oct;18(1):13–24. doi: 10.1016/0166-0934(87)90106-6. [DOI] [PubMed] [Google Scholar]
  4. Angsubhakorn S., Moe J. B., Marchette N. J., Palumbo N. E., Yoksan S., Bhamarapravati N. Neurovirulence effects of dengue-2 viruses on the rhesus (Macaca mulatta) brain and spinal cord. Southeast Asian J Trop Med Public Health. 1987 Mar;18(1):52–55. [PubMed] [Google Scholar]
  5. Angsubhakorn S., Yoksan S., Bhamarapravati N., Moe J. B., Marchette N. J., Pradermwong A., Sahaphong S. Dengue-4 vaccine: neurovirulence, viraemia and immune responses in rhesus and cynomolgus monkeys. Trans R Soc Trop Med Hyg. 1988;82(5):746–749. doi: 10.1016/0035-9203(88)90224-6. [DOI] [PubMed] [Google Scholar]
  6. Aung-Khin M., Ma-Ma K., Thant-Zin Changes in the tissues of the immune system in dengue haemorrhagic fever. J Trop Med Hyg. 1975 Dec;78(12):256–261. [PubMed] [Google Scholar]
  7. BEASLEY A. R., LICHTER W., SIGEL M. M. Studies on latent infections of tissue cultures with dengue virus. I. Characteristics of the system. Arch Gesamte Virusforsch. 1961;10:672–683. doi: 10.1007/BF01241644. [DOI] [PubMed] [Google Scholar]
  8. Bancroft W. H. Current status of dengue vaccines and prospects for the future. P R Health Sci J. 1987 Apr;6(1):23–26. [PubMed] [Google Scholar]
  9. Bancroft W. H., Scott R. M., Eckels K. H., Hoke C. H., Jr, Simms T. E., Jesrani K. D., Summers P. L., Dubois D. R., Tsoulos D., Russell P. K. Dengue virus type 2 vaccine: reactogenicity and immunogenicity in soldiers. J Infect Dis. 1984 Jun;149(6):1005–1010. doi: 10.1093/infdis/149.6.1005. [DOI] [PubMed] [Google Scholar]
  10. Barnes W. J., Rosen L. Fatal hemorrhagic disease and shock associated with primary dengue infection on a Pacific island. Am J Trop Med Hyg. 1974 May;23(3):495–506. doi: 10.4269/ajtmh.1974.23.495. [DOI] [PubMed] [Google Scholar]
  11. Bazan J. F., Fletterick R. J. Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses. Virology. 1989 Aug;171(2):637–639. doi: 10.1016/0042-6822(89)90639-9. [DOI] [PubMed] [Google Scholar]
  12. Bell J. R., Kinney R. M., Trent D. W., Lenches E. M., Dalgarno L., Strauss J. H. Amino-terminal amino acid sequences of structural proteins of three flaviviruses. Virology. 1985 May;143(1):224–229. doi: 10.1016/0042-6822(85)90110-2. [DOI] [PubMed] [Google Scholar]
  13. Bhamarapravati N., Tuchinda P., Boonyapaknavik V. Pathology of Thailand haemorrhagic fever: a study of 100 autopsy cases. Ann Trop Med Parasitol. 1967 Dec;61(4):500–510. doi: 10.1080/00034983.1967.11686519. [DOI] [PubMed] [Google Scholar]
  14. Bhamarapravati N., Yoksan S., Chayaniyayothin T., Angsubphakorn S., Bunyaratvej A. Immunization with a live attenuated dengue-2-virus candidate vaccine (16681-PDK 53): clinical, immunological and biological responses in adult volunteers. Bull World Health Organ. 1987;65(2):189–195. [PMC free article] [PubMed] [Google Scholar]
  15. Blobel G., Dobberstein B. Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol. 1975 Dec;67(3):835–851. doi: 10.1083/jcb.67.3.835. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Blok J., Kay B. H., Hall R. A., Gorman B. M. Isolation and characterization of dengue viruses serotype 1 from an epidemic in northern Queensland, Australia. Arch Virol. 1988;100(3-4):213–220. doi: 10.1007/BF01487684. [DOI] [PubMed] [Google Scholar]
  17. Blok J., Samuel S., Gibbs A. J., Vitarana U. T. Variation of the nucleotide and encoded amino acid sequences of the envelope gene from eight dengue-2 viruses. Arch Virol. 1989;105(1-2):39–53. doi: 10.1007/BF01311115. [DOI] [PubMed] [Google Scholar]
  18. Boonpucknavig S., Boonpucknavig V., Bhamarapravati N., Nimmannitya S. Immunofluorescence study of skin rash in patients with dengue hemorrhagic fever. Arch Pathol Lab Med. 1979 Aug;103(9):463–466. [PubMed] [Google Scholar]
  19. Boonpucknavig V., Bhamarapravati N., Boonpucknavig S., Futrakul P., Tanpaichitr P. Glomerular changes in dengue hemorrhagic fever. Arch Pathol Lab Med. 1976 Apr;100(4):206–212. [PubMed] [Google Scholar]
  20. Boulton R. W., Westaway E. G. Replication of the flavivirus Kunjin: proteins, glycoproteins, and maturation associated with cell membranes. Virology. 1976 Feb;69(2):416–430. doi: 10.1016/0042-6822(76)90473-6. [DOI] [PubMed] [Google Scholar]
  21. Bray M., Zhao B. T., Markoff L., Eckels K. H., Chanock R. M., Lai C. J. Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue virus encephalitis. J Virol. 1989 Jun;63(6):2853–2856. doi: 10.1128/jvi.63.6.2853-2856.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Brinton M. A., Dispoto J. H. Sequence and secondary structure analysis of the 5'-terminal region of flavivirus genome RNA. Virology. 1988 Feb;162(2):290–299. doi: 10.1016/0042-6822(88)90468-0. [DOI] [PubMed] [Google Scholar]
  23. Bukowski J. F., Kurane I., Lai C. J., Bray M., Falgout B., Ennis F. A. Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes. J Virol. 1989 Dec;63(12):5086–5091. doi: 10.1128/jvi.63.12.5086-5091.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Bundo K., Igarashi A. Antibody-capture ELISA for detection of immunoglobulin M antibodies in sera from Japanese encephalitis and dengue hemorrhagic fever patients. J Virol Methods. 1985 May;11(1):15–22. doi: 10.1016/0166-0934(85)90120-x. [DOI] [PubMed] [Google Scholar]
  25. Burke D. S., Nisalak A., Gentry M. K. Detection of flavivirus antibodies in human serum by epitope-blocking immunoassay. J Med Virol. 1987 Oct;23(2):165–173. doi: 10.1002/jmv.1890230209. [DOI] [PubMed] [Google Scholar]
  26. CASALS J., BROWN L. V. Hemagglutination with arthropod-borne viruses. J Exp Med. 1954 May 1;99(5):429–449. doi: 10.1084/jem.99.5.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. CLARKE D. H., CASALS J. Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. Am J Trop Med Hyg. 1958 Sep;7(5):561–573. doi: 10.4269/ajtmh.1958.7.561. [DOI] [PubMed] [Google Scholar]
  28. Cardiff R. D., Dalrymple J. M., Russell P. K. RNA polymerase in group B arbovirus (dengue-2) infected cells. Brief report. Arch Gesamte Virusforsch. 1973;40(3):392–396. doi: 10.1007/BF01242561. [DOI] [PubMed] [Google Scholar]
  29. Cardiff R. D., Russ S. B., Brandt W. E., Russell P. K. Cytological localization of Dengue-2 antigens: an immunological study with ultrastructural correlation. Infect Immun. 1973 May;7(5):809–816. doi: 10.1128/iai.7.5.809-816.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Cardosa M. J. Dengue virus isolation by antibody-dependent enhancement of infectivity in macrophages. Lancet. 1987 Jan 24;1(8526):193–194. doi: 10.1016/s0140-6736(87)90005-5. [DOI] [PubMed] [Google Scholar]
  31. Carey D. E. Chikungunya and dengue: a case of mistaken identity? J Hist Med Allied Sci. 1971 Jul;26(3):243–262. doi: 10.1093/jhmas/xxvi.3.243. [DOI] [PubMed] [Google Scholar]
  32. Castle E., Leidner U., Nowak T., Wengler G., Wengler G. Primary structure of the West Nile flavivirus genome region coding for all nonstructural proteins. Virology. 1986 Feb;149(1):10–26. doi: 10.1016/0042-6822(86)90082-6. [DOI] [PubMed] [Google Scholar]
  33. Castle E., Nowak T., Leidner U., Wengler G., Wengler G. Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins. Virology. 1985 Sep;145(2):227–236. doi: 10.1016/0042-6822(85)90156-4. [DOI] [PubMed] [Google Scholar]
  34. Chambers T. J., McCourt D. W., Rice C. M. Yellow fever virus proteins NS2A, NS2B, and NS4B: identification and partial N-terminal amino acid sequence analysis. Virology. 1989 Mar;169(1):100–109. doi: 10.1016/0042-6822(89)90045-7. [DOI] [PubMed] [Google Scholar]
  35. Chu M. C., O'Rourke E. J., Trent D. W. Genetic relatedness among structural protein genes of dengue 1 virus strains. J Gen Virol. 1989 Jul;70(Pt 7):1701–1712. doi: 10.1099/0022-1317-70-7-1701. [DOI] [PubMed] [Google Scholar]
  36. Chu P. W., Westaway E. G. Replication strategy of Kunjin virus: evidence for recycling role of replicative form RNA as template in semiconservative and asymmetric replication. Virology. 1985 Jan 15;140(1):68–79. doi: 10.1016/0042-6822(85)90446-5. [DOI] [PubMed] [Google Scholar]
  37. Chungue E., Boutin J. P., Roux J. Intérêt du titrage des IgM par technique immunoenzymatique pour le sérodiagnostic et la surveillance épidémiologique de la dengue en Polynésie Française. Res Virol. 1989 May-Jun;140(3):229–240. doi: 10.1016/s0923-2516(89)80100-1. [DOI] [PubMed] [Google Scholar]
  38. Cleaves G. R., Dubin D. T. Methylation status of intracellular dengue type 2 40 S RNA. Virology. 1979 Jul 15;96(1):159–165. doi: 10.1016/0042-6822(79)90181-8. [DOI] [PubMed] [Google Scholar]
  39. Cleaves G. R. Identification of dengue type 2 virus-specific high molecular weight proteins in virus-infected BHK cells. J Gen Virol. 1985 Dec;66(Pt 12):2767–2771. doi: 10.1099/0022-1317-66-12-2767. [DOI] [PubMed] [Google Scholar]
  40. Cleaves G. R., Ryan T. E., Schlesinger R. W. Identification and characterization of type 2 dengue virus replicative intermediate and replicative form RNAs. Virology. 1981 May;111(1):73–83. doi: 10.1016/0042-6822(81)90654-1. [DOI] [PubMed] [Google Scholar]
  41. Cohen S. N., Halstead S. B. Shock associated with dengue infection. I. Clinical and physiologic manifestations of dengue hemorrhagic fever in Thailand, 1964. J Pediatr. 1966 Mar;68(3):448–456. doi: 10.1016/s0022-3476(66)80249-4. [DOI] [PubMed] [Google Scholar]
  42. Coia G., Parker M. D., Speight G., Byrne M. E., Westaway E. G. Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified proteins. J Gen Virol. 1988 Jan;69(Pt 1):1–21. doi: 10.1099/0022-1317-69-1-1. [DOI] [PubMed] [Google Scholar]
  43. Cole G. A., Wisseman C. L., Jr, Nathanson N. Pathogenesis of type 1 dengue virus infection in suckling, weaning and adult mice. II. Immunofluorescent and histological studies. J Comp Pathol. 1973 Apr;83(2):243–252. doi: 10.1016/0021-9975(73)90048-0. [DOI] [PubMed] [Google Scholar]
  44. Cole G. A., Wisseman C. L., Jr Pathogenesis of type 1 dengue virus infection in suckling, weanling and adult mice. 1. The relation of virus replication to interferon and antibody formation. Am J Epidemiol. 1969 Jun;89(6):669–680. doi: 10.1093/oxfordjournals.aje.a120981. [DOI] [PubMed] [Google Scholar]
  45. DORRANCE W. R., FRANKEL J. W., GORDON I., PATTERSON P. R., SCHLESINGER R. W., WINTER J. W. Clinical and serologic response of man to immunization with attenuated dengue and yellow fever viruses. J Immunol. 1956 Nov;77(5):352–364. [PubMed] [Google Scholar]
  46. Dalgarno L., Trent D. W., Strauss J. H., Rice C. M. Partial nucleotide sequence of the Murray Valley encephalitis virus genome. Comparison of the encoded polypeptides with yellow fever virus structural and non-structural proteins. J Mol Biol. 1986 Feb 5;187(3):309–323. doi: 10.1016/0022-2836(86)90435-3. [DOI] [PubMed] [Google Scholar]
  47. Daughaday C. C., Brandt W. E., McCown J. M., Russell P. K. Evidence for two mechanisms of dengue virus infection of adherent human monocytes: trypsin-sensitive virus receptors and trypsin-resistant immune complex receptors. Infect Immun. 1981 May;32(2):469–473. doi: 10.1128/iai.32.2.469-473.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. De Madrid A. T., Porterfield J. S. The flaviviruses (group B arboviruses): a cross-neutralization study. J Gen Virol. 1974 Apr;23(1):91–96. doi: 10.1099/0022-1317-23-1-91. [DOI] [PubMed] [Google Scholar]
  49. Della-Porta A. J., Westaway E. G. Immune response in rabbits to virion and nonvirion antigens of the Flavivirus kunjin. Infect Immun. 1977 Mar;15(3):874–882. doi: 10.1128/iai.15.3.874-882.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Deubel V., Kinney R. M., Trent D. W. Nucleotide sequence and deduced amino acid sequence of the nonstructural proteins of dengue type 2 virus, Jamaica genotype: comparative analysis of the full-length genome. Virology. 1988 Jul;165(1):234–244. doi: 10.1016/0042-6822(88)90677-0. [DOI] [PubMed] [Google Scholar]
  51. Eckels K. H., Harrison V. R., Summers P. L., Russell P. K. Dengue-2 vaccine: preparation from a small-plaque virus clone. Infect Immun. 1980 Jan;27(1):175–180. doi: 10.1128/iai.27.1.175-180.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Eckels K. H., Kliks S. C., Dubois D. R., Wahl L. M., Bancroft W. H. The association of enhancing antibodies with seroconversion in humans receiving a dengue-2 live-virus vaccine. J Immunol. 1985 Dec;135(6):4201–4203. [PubMed] [Google Scholar]
  53. Eckels K. H., Scott R. M., Bancroft W. H., Brown J., Dubois D. R., Summers P. L., Russell P. K., Halstead S. B. Selection of attenuated dengue 4 viruses by serial passage in primary kidney cells. V. Human response to immunization with a candidate vaccine prepared in fetal rhesus lung cells. Am J Trop Med Hyg. 1984 Jul;33(4):684–689. doi: 10.4269/ajtmh.1984.33.684. [DOI] [PubMed] [Google Scholar]
  54. Eckels K. H., Summers P. L., Russell P. K. Temperature-sensitive events during the replication of the attenuated S-1 clone of dengue type 2 virus. Infect Immun. 1983 Feb;39(2):750–754. doi: 10.1128/iai.39.2.750-754.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Falgout B., Chanock R., Lai C. J. Proper processing of dengue virus nonstructural glycoprotein NS1 requires the N-terminal hydrophobic signal sequence and the downstream nonstructural protein NS2a. J Virol. 1989 May;63(5):1852–1860. doi: 10.1128/jvi.63.5.1852-1860.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Filshie B. K., Rehacek J. Studies of the morphology of Murray Valley encephalitis and Japanese encephalitis viruses growing in cultured mosquito cells. Virology. 1968 Mar;34(3):435–443. doi: 10.1016/0042-6822(68)90063-9. [DOI] [PubMed] [Google Scholar]
  57. Gollins S. W., Porterfield J. S. A new mechanism for the neutralization of enveloped viruses by antiviral antibody. Nature. 1986 May 15;321(6067):244–246. doi: 10.1038/321244a0. [DOI] [PubMed] [Google Scholar]
  58. Griffiths B. B., Grant L. S., Minott O. D., Belle E. A. An epidemic of dengue-like illness in Jamaica-1963. Am J Trop Med Hyg. 1968 Jul;17(4):584–589. doi: 10.4269/ajtmh.1968.17.584. [DOI] [PubMed] [Google Scholar]
  59. Grun J. B., Brinton M. A. Dissociation of NS5 from cell fractions containing West Nile virus-specific polymerase activity. J Virol. 1987 Nov;61(11):3641–3644. doi: 10.1128/jvi.61.11.3641-3644.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Gubler D. J. Aedes aegypti and Aedes aegypti-borne disease control in the 1990s: top down or bottom up. Charles Franklin Craig Lecture. Am J Trop Med Hyg. 1989 Jun;40(6):571–578. doi: 10.4269/ajtmh.1989.40.571. [DOI] [PubMed] [Google Scholar]
  61. Gubler D. J. Dengue and dengue hemorrhagic fever in the Americas. P R Health Sci J. 1987 Aug;6(2):107–111. [PubMed] [Google Scholar]
  62. Gubler D. J., Kuno G., Sather G. E., Velez M., Oliver A. Mosquito cell cultures and specific monoclonal antibodies in surveillance for dengue viruses. Am J Trop Med Hyg. 1984 Jan;33(1):158–165. doi: 10.4269/ajtmh.1984.33.158. [DOI] [PubMed] [Google Scholar]
  63. Gubler D. J., Reed D., Rosen L., Hitchcock J. R., Jr Epidemiologic, clinical, and virologic observations on dengue in the Kingdom of Tonga. Am J Trop Med Hyg. 1978 May;27(3):581–589. doi: 10.4269/ajtmh.1978.27.581. [DOI] [PubMed] [Google Scholar]
  64. Gubler D. J., Rosen L. A simple technique for demonstrating transmission of dengue virus by mosquitoes without the use of vertebrate hosts. Am J Trop Med Hyg. 1976 Jan;25(1):146–150. doi: 10.4269/ajtmh.1976.25.146. [DOI] [PubMed] [Google Scholar]
  65. Gubler D. J., Suharyono W., Lubis I., Eram S., Sulianti Saroso J. Epidemic dengue hemorrhagic fever in rural Indonesia. I. Virological and epidemiological studies. Am J Trop Med Hyg. 1979 Jul;28(4):701–710. [PubMed] [Google Scholar]
  66. Gubler D. J., Suharyono W., Tan R., Abidin M., Sie A. Viraemia in patients with naturally acquired dengue infection. Bull World Health Organ. 1981;59(4):623–630. [PMC free article] [PubMed] [Google Scholar]
  67. Guirakhoo F., Heinz F. X., Kunz C. Epitope model of tick-borne encephalitis virus envelope glycoprotein E: analysis of structural properties, role of carbohydrate side chain, and conformational changes occurring at acidic pH. Virology. 1989 Mar;169(1):90–99. doi: 10.1016/0042-6822(89)90044-5. [DOI] [PubMed] [Google Scholar]
  68. Guzman M. G., Kouri G. P., Bravo J., Calunga M., Soler M., Vazquez S., Venereo C. Dengue haemorrhagic fever in Cuba. I. Serological confirmation of clinical diagnosis. Trans R Soc Trop Med Hyg. 1984;78(2):235–238. doi: 10.1016/0035-9203(84)90285-2. [DOI] [PubMed] [Google Scholar]
  69. Guzman M. G., Kouri G. P., Bravo J., Soler M., Vazquez S., Santos M., Villaescusa R., Basanta P., Indan G., Ballester J. M. Dengue haemorrhagic fever in Cuba. II. Clinical investigations. Trans R Soc Trop Med Hyg. 1984;78(2):239–241. doi: 10.1016/0035-9203(84)90286-4. [DOI] [PubMed] [Google Scholar]
  70. HAMMONT W. M., SATHER G. E. PROBLEMS OF TYPING DENGUE VIRUSES. Mil Med. 1964 Feb;129:130–135. [PubMed] [Google Scholar]
  71. HAMMON W. M., RUDNICK A., SATHER G. E. Viruses associated with epidemic hemorrhagic fevers of the Philippines and Thailand. Science. 1960 Apr 15;131(3407):1102–1103. doi: 10.1126/science.131.3407.1102. [DOI] [PubMed] [Google Scholar]
  72. HAMMON W. M., SATHER G. E. VIROLOGICAL FINDINGS IN THE 1960 HEMORRHAGIC FEVER EPIDEMIC (DENGUE) IN THAILAND. Am J Trop Med Hyg. 1964 Jul;13:629–641. doi: 10.4269/ajtmh.1964.13.629. [DOI] [PubMed] [Google Scholar]
  73. HOTTA S., EVANS C. A. Cultivation of mouse-adapted dengue virus (type 1) in rhesus monkey tissue culture. J Infect Dis. 1956 Jan-Feb;98(1):88–97. doi: 10.1093/infdis/98.1.88. [DOI] [PubMed] [Google Scholar]
  74. Hafkin B., Kaplan J. E., Reed C., Elliott L. B., Fontaine R., Sather G. E., Kappus K. Reintroduction of dengue fever into the continental United States. I. Dengue surveillance in Texas, 1980. Am J Trop Med Hyg. 1982 Nov;31(6):1222–1228. doi: 10.4269/ajtmh.1982.31.1222. [DOI] [PubMed] [Google Scholar]
  75. Hahn Y. S., Galler R., Hunkapiller T., Dalrymple J. M., Strauss J. H., Strauss E. G. Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses. Virology. 1988 Jan;162(1):167–180. doi: 10.1016/0042-6822(88)90406-0. [DOI] [PubMed] [Google Scholar]
  76. Halstead S. B. Dengue and hemorrhagic fevers of Southeast Asia. Yale J Biol Med. 1965 Jun;37(6):434–454. [PMC free article] [PubMed] [Google Scholar]
  77. Halstead S. B., Eckels K. H., Putvatana R., Larsen L. K., Marchette N. J. Selection of attenuated dengue 4 viruses by serial passage in primary kidney cells. IV. Characterization of a vaccine candidate in fetal rhesus lung cells. Am J Trop Med Hyg. 1984 Jul;33(4):679–683. doi: 10.4269/ajtmh.1984.33.679. [DOI] [PubMed] [Google Scholar]
  78. Halstead S. B. Mosquito-borne haemorrhagic fevers of South and South-East Asia. Bull World Health Organ. 1966;35(1):3–15. [PMC free article] [PubMed] [Google Scholar]
  79. Halstead S. B., Nimmannitya S., Margiotta M. R. Dengue d chikungunya virus infection in man in Thailand, 1962-1964. II. Observations on disease in outpatients. Am J Trop Med Hyg. 1969 Nov;18(6):972–983. doi: 10.4269/ajtmh.1969.18.972. [DOI] [PubMed] [Google Scholar]
  80. Halstead S. B., O'Rourke E. J. Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. J Exp Med. 1977 Jul 1;146(1):201–217. doi: 10.1084/jem.146.1.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Halstead S. B. Observations related to pathogensis of dengue hemorrhagic fever. VI. Hypotheses and discussion. Yale J Biol Med. 1970 Apr;42(5):350–362. [PMC free article] [PubMed] [Google Scholar]
  82. Halstead S. B., Papaevangelou G. Transmission of dengue 1 and 2 viruses in Greece in 1928. Am J Trop Med Hyg. 1980 Jul;29(4):635–637. doi: 10.4269/ajtmh.1980.29.635. [DOI] [PubMed] [Google Scholar]
  83. Halstead S. B. Pathogenesis of dengue: challenges to molecular biology. Science. 1988 Jan 29;239(4839):476–481. doi: 10.1126/science.3277268. [DOI] [PubMed] [Google Scholar]
  84. Halstead S. B., Rojanasuphot S., Sangkawibha N. Original antigenic sin in dengue. Am J Trop Med Hyg. 1983 Jan;32(1):154–156. doi: 10.4269/ajtmh.1983.32.154. [DOI] [PubMed] [Google Scholar]
  85. Halstead S. B. The Alexander D. Langmuir Lecture. The pathogenesis of dengue. Molecular epidemiology in infectious disease. Am J Epidemiol. 1981 Nov;114(5):632–648. doi: 10.1093/oxfordjournals.aje.a113235. [DOI] [PubMed] [Google Scholar]
  86. Halstead S. B., Udomsakdi S., Singharaj P., Nisalak A. Dengue chikungunya virus infection in man in Thailand, 1962-1964. 3. Clinical, epidemiologic, and virologic observations on disease in non-indigenous white persons. Am J Trop Med Hyg. 1969 Nov;18(6):984–996. doi: 10.4269/ajtmh.1969.18.984. [DOI] [PubMed] [Google Scholar]
  87. Harrison V. R., Eckels K. H., Sagartz J. W., Russell P. K. Virulence and immunogenicity of a temperature-sensitive dengue-2 virus in lower primates. Infect Immun. 1977 Oct;18(1):151–156. doi: 10.1128/iai.18.1.151-156.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Hase T., Summers P. L., Eckels K. H., Baze W. B. An electron and immunoelectron microscopic study of dengue-2 virus infection of cultured mosquito cells: maturation events. Arch Virol. 1987;92(3-4):273–291. doi: 10.1007/BF01317484. [DOI] [PubMed] [Google Scholar]
  89. Hase T., Summers P. L., Eckels K. H., Baze W. B. Maturation process of Japanese encephalitis virus in cultured mosquito cells in vitro and mouse brain cells in vivo. Arch Virol. 1987;96(3-4):135–151. doi: 10.1007/BF01320956. [DOI] [PubMed] [Google Scholar]
  90. Hase T., Summers P. L., Eckels K. H. Flavivirus entry into cultured mosquito cells and human peripheral blood monocytes. Arch Virol. 1989;104(1-2):129–143. doi: 10.1007/BF01313814. [DOI] [PubMed] [Google Scholar]
  91. Heinz F. X., Berger R., Tuma W., Kunz C. A topological and functional model of epitopes on the structural glycoprotein of tick-borne encephalitis virus defined by monoclonal antibodies. Virology. 1983 Apr 30;126(2):525–537. doi: 10.1016/s0042-6822(83)80010-5. [DOI] [PubMed] [Google Scholar]
  92. Henchal E. A., Gentry M. K., McCown J. M., Brandt W. E. Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence. Am J Trop Med Hyg. 1982 Jul;31(4):830–836. doi: 10.4269/ajtmh.1982.31.830. [DOI] [PubMed] [Google Scholar]
  93. Henchal E. A., Henchal L. S., Schlesinger J. J. Synergistic interactions of anti-NS1 monoclonal antibodies protect passively immunized mice from lethal challenge with dengue 2 virus. J Gen Virol. 1988 Aug;69(Pt 8):2101–2107. doi: 10.1099/0022-1317-69-8-2101. [DOI] [PubMed] [Google Scholar]
  94. Henchal E. A., McCown J. M., Burke D. S., Seguin M. C., Brandt W. E. Epitopic analysis of antigenic determinants on the surface of dengue-2 virions using monoclonal antibodies. Am J Trop Med Hyg. 1985 Jan;34(1):162–169. doi: 10.4269/ajtmh.1985.34.162. [DOI] [PubMed] [Google Scholar]
  95. Henchal E. A., McCown J. M., Seguin M. C., Gentry M. K., Brandt W. E. Rapid identification of dengue virus isolates by using monoclonal antibodies in an indirect immunofluorescence assay. Am J Trop Med Hyg. 1983 Jan;32(1):164–169. doi: 10.4269/ajtmh.1983.32.164. [DOI] [PubMed] [Google Scholar]
  96. Henchal E. A., Narupiti S., Feighny R., Padmanabhan R., Vakharia V. Detection of dengue virus RNA using nucleic acid hybridization. J Virol Methods. 1987 Feb;15(3):187–200. doi: 10.1016/0166-0934(87)90097-8. [DOI] [PubMed] [Google Scholar]
  97. Henchal E. A., Repik P. M., McCown J. M., Brandt W. E. Identification of an antigenic and genetic variant of dengue-4 virus from the Caribbean. Am J Trop Med Hyg. 1986 Mar;35(2):393–400. doi: 10.4269/ajtmh.1986.35.393. [DOI] [PubMed] [Google Scholar]
  98. Hull B., Tikasingh E., de Souza M., Martinez R. Natural transovarial transmission of dengue 4 virus in Aedes aegypti in Trinidad. Am J Trop Med Hyg. 1984 Nov;33(6):1248–1250. doi: 10.4269/ajtmh.1984.33.1248. [DOI] [PubMed] [Google Scholar]
  99. Igarashi A. Isolation of a Singh's Aedes albopictus cell clone sensitive to Dengue and Chikungunya viruses. J Gen Virol. 1978 Sep;40(3):531–544. doi: 10.1099/0022-1317-40-3-531. [DOI] [PubMed] [Google Scholar]
  100. Innis B. L., Eckels K. H., Kraiselburd E., Dubois D. R., Meadors G. F., Gubler D. J., Burke D. S., Bancroft W. H. Virulence of a live dengue virus vaccine candidate: a possible new marker of dengue virus attenuation. J Infect Dis. 1988 Oct;158(4):876–880. doi: 10.1093/infdis/158.4.876. [DOI] [PubMed] [Google Scholar]
  101. Innis B. L., Nisalak A., Nimmannitya S., Kusalerdchariya S., Chongswasdi V., Suntayakorn S., Puttisri P., Hoke C. H. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg. 1989 Apr;40(4):418–427. doi: 10.4269/ajtmh.1989.40.418. [DOI] [PubMed] [Google Scholar]
  102. Innis B. L., Thirawuth V., Hemachudha C. Identification of continuous epitopes of the envelope glycoprotein of dengue type 2 virus. Am J Trop Med Hyg. 1989 Jun;40(6):676–687. doi: 10.4269/ajtmh.1989.40.676. [DOI] [PubMed] [Google Scholar]
  103. Irie K., Mohan P. M., Sasaguri Y., Putnak R., Padmanabhan R. Sequence analysis of cloned dengue virus type 2 genome (New Guinea-C strain). Gene. 1989 Feb 20;75(2):197–211. doi: 10.1016/0378-1119(89)90266-7. [DOI] [PubMed] [Google Scholar]
  104. Ishak R., Tovey D. G., Howard C. R. Morphogenesis of yellow fever virus 17D in infected cell cultures. J Gen Virol. 1988 Feb;69(Pt 2):325–335. doi: 10.1099/0022-1317-69-2-325. [DOI] [PubMed] [Google Scholar]
  105. Kaufman B. M., Summers P. L., Dubois D. R., Cohen W. H., Gentry M. K., Timchak R. L., Burke D. S., Eckels K. H. Monoclonal antibodies for dengue virus prM glycoprotein protect mice against lethal dengue infection. Am J Trop Med Hyg. 1989 Nov;41(5):576–580. doi: 10.4269/ajtmh.1989.41.576. [DOI] [PubMed] [Google Scholar]
  106. Kaufman B. M., Summers P. L., Dubois D. R., Eckels K. H. Monoclonal antibodies against dengue 2 virus E-glycoprotein protect mice against lethal dengue infection. Am J Trop Med Hyg. 1987 Mar;36(2):427–434. doi: 10.4269/ajtmh.1987.36.427. [DOI] [PubMed] [Google Scholar]
  107. Khan A. M., Wright P. J. Detection of flavivirus RNA in infected cells using photobiotin-labelled hybridization probes. J Virol Methods. 1987 Feb;15(2):121–130. doi: 10.1016/0166-0934(87)90055-3. [DOI] [PubMed] [Google Scholar]
  108. Khin M. M., Than K. A. Transovarial transmission of dengue 2 virus by Aedes aegypti in nature. Am J Trop Med Hyg. 1983 May;32(3):590–594. doi: 10.4269/ajtmh.1983.32.590. [DOI] [PubMed] [Google Scholar]
  109. Kimura T., Gollins S. W., Porterfield J. S. The effect of pH on the early interaction of West Nile virus with P388D1 cells. J Gen Virol. 1986 Nov;67(Pt 11):2423–2433. doi: 10.1099/0022-1317-67-11-2423. [DOI] [PubMed] [Google Scholar]
  110. Kimura T., Ohyama A. Association between the pH-dependent conformational change of West Nile flavivirus E protein and virus-mediated membrane fusion. J Gen Virol. 1988 Jun;69(Pt 6):1247–1254. doi: 10.1099/0022-1317-69-6-1247. [DOI] [PubMed] [Google Scholar]
  111. Kliks S. C., Nimmanitya S., Nisalak A., Burke D. S. Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants. Am J Trop Med Hyg. 1988 Mar;38(2):411–419. doi: 10.4269/ajtmh.1988.38.411. [DOI] [PubMed] [Google Scholar]
  112. Kliks S. C., Nisalak A., Brandt W. E., Wahl L., Burke D. S. Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. Am J Trop Med Hyg. 1989 Apr;40(4):444–451. doi: 10.4269/ajtmh.1989.40.444. [DOI] [PubMed] [Google Scholar]
  113. Kontny U., Kurane I., Ennis F. A. Gamma interferon augments Fc gamma receptor-mediated dengue virus infection of human monocytic cells. J Virol. 1988 Nov;62(11):3928–3933. doi: 10.1128/jvi.62.11.3928-3933.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  114. Kraiselburd E. Dengue virus vaccine studies in Puerto Rico: a review. P R Health Sci J. 1987 Apr;6(1):27–29. [PubMed] [Google Scholar]
  115. Kraiselburd E., Gubler D. J., Kessler M. J. Quantity of dengue virus required to infect rhesus monkeys. Trans R Soc Trop Med Hyg. 1985;79(2):248–251. doi: 10.1016/0035-9203(85)90348-7. [DOI] [PubMed] [Google Scholar]
  116. Kraiselburd E., Kessler M. J., Torres-Blasini G. Lack of viraemia and limited antibody response of dengue virus immune rhesus monkeys after vaccination with DEN-2/S-1 vaccine. Trans R Soc Trop Med Hyg. 1984;78(4):445–448. doi: 10.1016/0035-9203(84)90055-5. [DOI] [PubMed] [Google Scholar]
  117. Kuberski T. T., Rosen L. A simple technique for the detection of dengue antigen in mosquitoes by immunofluorescence. Am J Trop Med Hyg. 1977 May;26(3):533–537. doi: 10.4269/ajtmh.1977.26.533. [DOI] [PubMed] [Google Scholar]
  118. Kuberski T. T., Rosen L. Identification of dengue viruses using complement fixing antigen produced in mosquitoes. Am J Trop Med Hyg. 1977 May;26(3):538–543. doi: 10.4269/ajtmh.1977.26.538. [DOI] [PubMed] [Google Scholar]
  119. Kuberski T., Rosen L., Reed D., Mataika J. Clinical and laboratory observations on patients with primary and secondary dengue type 1 infections with hemorrhagic manifestations in Fiji. Am J Trop Med Hyg. 1977 Jul;26(4):775–783. doi: 10.4269/ajtmh.1977.26.775. [DOI] [PubMed] [Google Scholar]
  120. Kuno G., Gubler D. J., Santiago de Weil N. S. Antigen capture ELISA for the identification of dengue viruses. J Virol Methods. 1985 Oct;12(1-2):93–103. doi: 10.1016/0166-0934(85)90011-4. [DOI] [PubMed] [Google Scholar]
  121. Kuno G., Gubler D. J., Vélez M., Oliver A. Comparative sensitivity of three mosquito cell lines for isolation of dengue viruses. Bull World Health Organ. 1985;63(2):279–286. [PMC free article] [PubMed] [Google Scholar]
  122. Kuno G. Persistent infection of a nonvector mosquito cell line (TRA-171) with dengue viruses. Intervirology. 1982;18(1-2):45–55. doi: 10.1159/000149303. [DOI] [PubMed] [Google Scholar]
  123. Kurane I., Innis B. L., Nisalak A., Hoke C., Nimmannitya S., Meager A., Ennis F. A. Human T cell responses to dengue virus antigens. Proliferative responses and interferon gamma production. J Clin Invest. 1989 Feb;83(2):506–513. doi: 10.1172/JCI113911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  124. Kurane I., Kontny U., Janus J., Ennis F. A. Dengue-2 virus infection of human mononuclear cell lines and establishment of persistent infections. Arch Virol. 1990;110(1-2):91–101. doi: 10.1007/BF01310705. [DOI] [PubMed] [Google Scholar]
  125. Kurane I., Meager A., Ennis F. A. Dengue virus-specific human T cell clones. Serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity. J Exp Med. 1989 Sep 1;170(3):763–775. doi: 10.1084/jem.170.3.763. [DOI] [PMC free article] [PubMed] [Google Scholar]
  126. Kyte J., Doolittle R. F. A simple method for displaying the hydropathic character of a protein. J Mol Biol. 1982 May 5;157(1):105–132. doi: 10.1016/0022-2836(82)90515-0. [DOI] [PubMed] [Google Scholar]
  127. Lam S. K., Chew C. B., Poon G. K., Ramalingam S., Seow S. C., Pang T. Isolation of dengue viruses by intracerebral inoculation of mosquito larvae. J Virol Methods. 1986 Sep;14(2):133–140. doi: 10.1016/0166-0934(86)90044-3. [DOI] [PubMed] [Google Scholar]
  128. Leary K., Blair C. D. Sequential events in the morphogenesis of japanese Encephalitis virus. J Ultrastruct Res. 1980 Aug;72(2):123–129. doi: 10.1016/s0022-5320(80)90050-7. [DOI] [PubMed] [Google Scholar]
  129. MAGUIRE T., MILES J. A. THE ARBOVIRUS CARRIER STATE IN TISSUE CULTURES. Arch Gesamte Virusforsch. 1965;15:457–474. doi: 10.1007/BF01245238. [DOI] [PubMed] [Google Scholar]
  130. MEIKLEJOHN G., ENGLAND B., LENNETTE Propagation of dengue virus strains in unweaned mice. Am J Trop Med Hyg. 1952 Jan;1(1):51–58. doi: 10.4269/ajtmh.1952.1.51. [DOI] [PubMed] [Google Scholar]
  131. Mackow E., Makino Y., Zhao B. T., Zhang Y. M., Markoff L., Buckler-White A., Guiler M., Chanock R., Lai C. J. The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins. Virology. 1987 Aug;159(2):217–228. doi: 10.1016/0042-6822(87)90458-2. [DOI] [PubMed] [Google Scholar]
  132. Maguire T., Miles J. A., Macnamara F. N., Wilkinson P. J., Austin F. J., Mataika J. U. Mosquito-borne infections in Fiji. V. The 1971-73 dengue epidemic. J Hyg (Lond) 1974 Oct;73(2):263–270. doi: 10.1017/s0022172400024116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Malewicz B., Anderson L. E., Crilly K., Jenkin H. M. Fetal rhesus monkey lung cells can be grown in serum-free medium for the replication of dengue-2 vaccine virus. In Vitro Cell Dev Biol. 1985 Aug;21(8):470–476. doi: 10.1007/BF02620836. [DOI] [PubMed] [Google Scholar]
  134. Malison M. D., Waterman S. H. Dengue fever in the United States. A report of a cluster of imported cases and review of the clinical, epidemiologic, and public health aspects of the disease. JAMA. 1983 Jan 28;249(4):496–500. doi: 10.1001/jama.249.4.496. [DOI] [PubMed] [Google Scholar]
  135. Mandl C. W., Guirakhoo F., Holzmann H., Heinz F. X., Kunz C. Antigenic structure of the flavivirus envelope protein E at the molecular level, using tick-borne encephalitis virus as a model. J Virol. 1989 Feb;63(2):564–571. doi: 10.1128/jvi.63.2.564-571.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  136. Mandl C. W., Heinz F. X., Kunz C. Sequence of the structural proteins of tick-borne encephalitis virus (western subtype) and comparative analysis with other flaviviruses. Virology. 1988 Sep;166(1):197–205. doi: 10.1016/0042-6822(88)90161-4. [DOI] [PubMed] [Google Scholar]
  137. Markoff L. In vitro processing of dengue virus structural proteins: cleavage of the pre-membrane protein. J Virol. 1989 Aug;63(8):3345–3352. doi: 10.1128/jvi.63.8.3345-3352.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  138. Mason P. W. Maturation of Japanese encephalitis virus glycoproteins produced by infected mammalian and mosquito cells. Virology. 1989 Apr;169(2):354–364. doi: 10.1016/0042-6822(89)90161-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Mason P. W., McAda P. C., Mason T. L., Fournier M. J. Sequence of the dengue-1 virus genome in the region encoding the three structural proteins and the major nonstructural protein NS1. Virology. 1987 Nov;161(1):262–267. doi: 10.1016/0042-6822(87)90196-6. [DOI] [PubMed] [Google Scholar]
  140. Matsumura T., Stollar V., Schlesinger R. W. Studies on the nature of dengue viruses. V. Structure and development of dengue virus in Vero cells. Virology. 1971 Nov;46(2):344–355. doi: 10.1016/0042-6822(71)90036-5. [DOI] [PubMed] [Google Scholar]
  141. McAda P. C., Mason P. W., Schmaljohn C. S., Dalrymple J. M., Mason T. L., Fournier M. J. Partial nucleotide sequence of the Japanese encephalitis virus genome. Virology. 1987 Jun;158(2):348–360. doi: 10.1016/0042-6822(87)90207-8. [DOI] [PubMed] [Google Scholar]
  142. McKee K. T., Jr, Bancroft W. H., Eckels K. H., Redfield R. R., Summers P. L., Russell P. K. Lack of attenuation of a candidate dengue 1 vaccine (45AZ5) in human volunteers. Am J Trop Med Hyg. 1987 Mar;36(2):435–442. doi: 10.4269/ajtmh.1987.36.435. [DOI] [PubMed] [Google Scholar]
  143. Monath T. P. Neutralizing antibody responses in the major immunoglobulin classes to yellow fever 17D vaccination of humans. Am J Epidemiol. 1971 Feb;93(2):122–129. doi: 10.1093/oxfordjournals.aje.a121232. [DOI] [PubMed] [Google Scholar]
  144. Monath T. P., Wands J. R., Hill L. J., Brown N. V., Marciniak R. A., Wong M. A., Gentry M. K., Burke D. S., Grant J. A., Trent D. W. Geographic classification of dengue-2 virus strains by antigen signature analysis. Virology. 1986 Oct 30;154(2):313–324. doi: 10.1016/0042-6822(86)90457-5. [DOI] [PubMed] [Google Scholar]
  145. Monath T. P., Wands J. R., Hill L. J., Gentry M. K., Gubler D. J. Multisite monoclonal immunoassay for dengue viruses: detection of viraemic human sera and interference by heterologous antibody. J Gen Virol. 1986 Apr;67(Pt 4):639–650. doi: 10.1099/0022-1317-67-4-639. [DOI] [PubMed] [Google Scholar]
  146. Moreau J. P., Rosen L., Saugrain J., Lagraulet J. An epidemic of dengue on Tahiti associated with hemorrhagic manifestations. Am J Trop Med Hyg. 1973 Mar;22(2):237–241. doi: 10.4269/ajtmh.1973.22.237. [DOI] [PubMed] [Google Scholar]
  147. Morens D. M., Halstead S. B. Disease severity-related antigenic differences in dengue 2 strains detected by dengue 4 monoclonal antibodies. J Med Virol. 1987 Jun;22(2):169–174. doi: 10.1002/jmv.1890220208. [DOI] [PubMed] [Google Scholar]
  148. Morens D. M., Halstead S. B., Repik P. M., Putvatana R., Raybourne N. Simplified plaque reduction neutralization assay for dengue viruses by semimicro methods in BHK-21 cells: comparison of the BHK suspension test with standard plaque reduction neutralization. J Clin Microbiol. 1985 Aug;22(2):250–254. doi: 10.1128/jcm.22.2.250-254.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Morens D. M., Sather G. E., Gubler D. J., Rammohan M., Woodall J. P. Dengue shock syndrome in an American traveler with primary dengue 3 infection. Am J Trop Med Hyg. 1987 Mar;36(2):424–426. doi: 10.4269/ajtmh.1987.36.424. [DOI] [PubMed] [Google Scholar]
  150. Myers R. M., Varkey M. J. A note on sequential dengue infection, presumptive and proved, with report of an instance of a third proved attack in one individual. Indian J Med Res. 1971 Aug;59(8):1231–1236. [PubMed] [Google Scholar]
  151. NAKAMURA M. Infectious ribonucleic acids derived from mouse brains infected with two kinds of arbor virus group B. Nature. 1961 Aug 5;191:624–624. doi: 10.1038/191624a0. [DOI] [PubMed] [Google Scholar]
  152. Nakao S., Lai C. J., Young N. S. Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines. Blood. 1989 Sep;74(4):1235–1240. [PubMed] [Google Scholar]
  153. Ng M. L. Ultrastructural studies of Kunjin virus-infected Aedes albopictus cells. J Gen Virol. 1987 Feb;68(Pt 2):577–582. doi: 10.1099/0022-1317-68-2-577. [DOI] [PubMed] [Google Scholar]
  154. Nimmannitya S., Halstead S. B., Cohen S. N., Margiotta M. R. Dengue and chikungunya virus infection in man in Thailand, 1962-1964. I. Observations on hospitalized patients with hemorrhagic fever. Am J Trop Med Hyg. 1969 Nov;18(6):954–971. doi: 10.4269/ajtmh.1969.18.954. [DOI] [PubMed] [Google Scholar]
  155. Nowak T., Färber P. M., Wengler G., Wengler G. Analyses of the terminal sequences of West Nile virus structural proteins and of the in vitro translation of these proteins allow the proposal of a complete scheme of the proteolytic cleavages involved in their synthesis. Virology. 1989 Apr;169(2):365–376. doi: 10.1016/0042-6822(89)90162-1. [DOI] [PubMed] [Google Scholar]
  156. Nowak T., Wengler G. Analysis of disulfides present in the membrane proteins of the West Nile flavivirus. Virology. 1987 Jan;156(1):127–137. doi: 10.1016/0042-6822(87)90443-0. [DOI] [PubMed] [Google Scholar]
  157. OTA Z. ELECTRON MICROSCOPE STUDY OF THE DEVELOPMENT OF JAPANESE B ENCEPHALITIS VIRUS IN PORCINE KIDNEY STABLE (PS) CELLS. Virology. 1965 Mar;25:372–378. doi: 10.1016/0042-6822(65)90057-7. [DOI] [PubMed] [Google Scholar]
  158. Olson K., Blair C., Padmanabhan R., Beaty B. Detection of dengue virus type 2 in Aedes albopictus by nucleic acid hybridization with strand-specific RNA probes. J Clin Microbiol. 1988 Mar;26(3):579–581. doi: 10.1128/jcm.26.3.579-581.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  159. Osatomi K., Fuke I., Tsuru D., Shiba T., Sakaki Y., Sumiyoshi H. Nucleotide sequence of dengue type 3 virus genomic RNA encoding viral structural proteins. Virus Genes. 1988 Oct;2(1):99–108. doi: 10.1007/BF00569739. [DOI] [PubMed] [Google Scholar]
  160. Pang T., Lam S. K., Chew C. B., Poon G. K., Ramalingam S. Detection of dengue virus by immunofluorescence following inoculation of mosquito larvae. Lancet. 1983 Jun 4;1(8336):1271–1271. doi: 10.1016/s0140-6736(83)92714-9. [DOI] [PubMed] [Google Scholar]
  161. Paul S. D., Singh K. R., Bhat U. K. A study on the cytopathic effect of arboviruses on cultures from Aedes albopictus cell line. Indian J Med Res. 1969 Feb;57(2):339–348. [PubMed] [Google Scholar]
  162. Perlman D., Halvorson H. O. A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides. J Mol Biol. 1983 Jun 25;167(2):391–409. doi: 10.1016/s0022-2836(83)80341-6. [DOI] [PubMed] [Google Scholar]
  163. Price W. H., Casals J., Thind I., O'Leary W. Sequential immunization procedure against Group B arboviruses using living attenuated 17D yellow fever virus, living attenuated Langat E5 virus, and living attenuated dengue 2 virus (New Guinea C isolate). Am J Trop Med Hyg. 1973 Jul;22(4):509–523. doi: 10.4269/ajtmh.1973.22.509. [DOI] [PubMed] [Google Scholar]
  164. Putvatana R., Yoksan S., Chayayodhin T., Bhamarapravati N., Halstead S. B. Absence of dengue 2 infection enhancement in human sera containing Japanese encephalitis antibodies. Am J Trop Med Hyg. 1984 Mar;33(2):288–294. doi: 10.4269/ajtmh.1984.33.288. [DOI] [PubMed] [Google Scholar]
  165. Qureshi A. A., Trent D. W. Group B arbovirus structural and nonstructural antigens. 3. Serological specificity of solubilized intracellular viral proteins. Infect Immun. 1973 Dec;8(6):993–999. doi: 10.1128/iai.8.6.993-999.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  166. ROSEN L. Experimental infection of New World monkeys with dengue and yellow fever viruses. Am J Trop Med Hyg. 1958 Jul;7(4):406–410. doi: 10.4269/ajtmh.1958.7.406. [DOI] [PubMed] [Google Scholar]
  167. ROSEN L., ROZEBOOM L. E., SWEET B. H., SABIN A. B. The transmission of dengue by Aedes polynesiensis Marks. Am J Trop Med Hyg. 1954 Sep;3(5):878–882. doi: 10.4269/ajtmh.1954.3.878. [DOI] [PubMed] [Google Scholar]
  168. Randolph V. B., Winkler G., Stollar V. Acidotropic amines inhibit proteolytic processing of flavivirus prM protein. Virology. 1990 Feb;174(2):450–458. doi: 10.1016/0042-6822(90)90099-d. [DOI] [PubMed] [Google Scholar]
  169. Repik P. M., Dalrymple J. M., Brandt W. E., McCown J. M., Russell P. K. RNA fingerprinting as a method for distinguishing dengue 1 virus strains. Am J Trop Med Hyg. 1983 May;32(3):577–589. doi: 10.4269/ajtmh.1983.32.577. [DOI] [PubMed] [Google Scholar]
  170. Rice C. M., Grakoui A., Galler R., Chambers T. J. Transcription of infectious yellow fever RNA from full-length cDNA templates produced by in vitro ligation. New Biol. 1989 Dec;1(3):285–296. [PubMed] [Google Scholar]
  171. Rice C. M., Lenches E. M., Eddy S. R., Shin S. J., Sheets R. L., Strauss J. H. Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science. 1985 Aug 23;229(4715):726–733. doi: 10.1126/science.4023707. [DOI] [PubMed] [Google Scholar]
  172. Rico-Hesse R. Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology. 1990 Feb;174(2):479–493. doi: 10.1016/0042-6822(90)90102-w. [DOI] [PubMed] [Google Scholar]
  173. Rosen L. A recent outbreak of dengue in French Polynesia. Jpn J Med Sci Biol. 1967 Dec;20 (Suppl):67–69. [PubMed] [Google Scholar]
  174. Rosen L., Roseboom L. E., Gubler D. J., Lien J. C., Chaniotis B. N. Comparative susceptibility of mosquito species and strains to oral and parenteral infection with dengue and Japanese encephalitis viruses. Am J Trop Med Hyg. 1985 May;34(3):603–615. doi: 10.4269/ajtmh.1985.34.603. [DOI] [PubMed] [Google Scholar]
  175. Rosen L., Shroyer D. A., Tesh R. B., Freier J. E., Lien J. C. Transovarial transmission of dengue viruses by mosquitoes: Aedes albopictus and Aedes aegypti. Am J Trop Med Hyg. 1983 Sep;32(5):1108–1119. doi: 10.4269/ajtmh.1983.32.1108. [DOI] [PubMed] [Google Scholar]
  176. Rudnick A. Studies of the ecology of dengue in Malaysia: a preliminary report. J Med Entomol. 1965 Jun;2(2):203–208. doi: 10.1093/jmedent/2.2.203. [DOI] [PubMed] [Google Scholar]
  177. Russell P. K., Buescher E. L., McCown J. M., Ordõnez J. Recovery of dengue viruses from patients during epidemics in Puerto Rico and East Pakistan. Am J Trop Med Hyg. 1966 Jul;15(4):573–579. doi: 10.4269/ajtmh.1966.15.573. [DOI] [PubMed] [Google Scholar]
  178. Russell P. K., Chiewsilp D., Brandt W. E. Immunoprecipitation analysis of soluble complement-fixing antigens of dengue viruses. J Immunol. 1970 Oct;105(4):838–845. [PubMed] [Google Scholar]
  179. Russell P. K., Gould D. J., Yuill T. M., Nisalak A., Winter P. E. Recovery of dengue-4 viruses from mosquito vectors and patients during an epidemic of dengue hemorrhagic fever. Am J Trop Med Hyg. 1969 Jul;18(4):580–583. doi: 10.4269/ajtmh.1969.18.580. [DOI] [PubMed] [Google Scholar]
  180. Russell P. K., McCown J. M. Comparison of dengue-2 and dengue-3 virus strains by neutralization tests and identification of a subtype of dengue-3. Am J Trop Med Hyg. 1972 Jan;21(2):97–99. doi: 10.4269/ajtmh.1972.21.97. [DOI] [PubMed] [Google Scholar]
  181. Russell P. K., Nisalak A. Dengue virus identification by the plaque reduction neutralization test. J Immunol. 1967 Aug;99(2):291–296. [PubMed] [Google Scholar]
  182. Russell P. K., Nisalak A., Sukhavachana P., Vivona S. A plaque reduction test for dengue virus neutralizing antibodies. J Immunol. 1967 Aug;99(2):285–290. [PubMed] [Google Scholar]
  183. Russell P. K., Yuill T. M., Nisalak A., Udomsakdi S., Gould D. J., Winter P. E. An insular outbreak of dengue hemorrhagic fever. II. Virologic and serologic studies. Am J Trop Med Hyg. 1968 Jul;17(4):600–608. doi: 10.4269/ajtmh.1968.17.600. [DOI] [PubMed] [Google Scholar]
  184. SABIN A. B. Genetic, hormonal and age factors in natural resistance to certain viruses. Ann N Y Acad Sci. 1952 Jul 10;54(6):936–944. doi: 10.1111/j.1749-6632.1952.tb39968.x. [DOI] [PubMed] [Google Scholar]
  185. SABIN A. B. Recent advances in our knowledge of dengue and sandfly fever. Am J Trop Med Hyg. 1955 Mar;4(2):198–207. doi: 10.4269/ajtmh.1955.4.198. [DOI] [PubMed] [Google Scholar]
  186. SABIN A. B. Research on dengue during World War II. Am J Trop Med Hyg. 1952 Jan;1(1):30–50. doi: 10.4269/ajtmh.1952.1.30. [DOI] [PubMed] [Google Scholar]
  187. SABIN A. B. The dengue group of viruses and its family relationships. Bacteriol Rev. 1950 Sep;14(3):225–232. [PubMed] [Google Scholar]
  188. SCHLESINGER R. W. Propagation in chick embryos of dengus virus, Hawaiian strain. II. Findings in infected eggs. Proc Soc Exp Biol Med. 1951 Apr;76(4):817–823. doi: 10.3181/00379727-76-18641. [DOI] [PubMed] [Google Scholar]
  189. SCHLESINGER W., FRANKEL J. W. Adaptation of the New Guinea B strain of dengue virus to suckling and to adult swiss mice; a study in viral variation. Am J Trop Med Hyg. 1952 Jan;1(1):66–77. doi: 10.4269/ajtmh.1952.1.66. [DOI] [PubMed] [Google Scholar]
  190. SCHULZE I. T., SCHLESINGER R. W. Plaque assay of dengue and other group B arthropod-borne viruses under methyl cellulose overlay media. Virology. 1963 Jan;19:40–48. doi: 10.1016/0042-6822(63)90022-9. [DOI] [PubMed] [Google Scholar]
  191. SMITHBURN K. C. Antigenic relationships among certain arthropod-borne viruses as revealed by neutralization tests. J Immunol. 1954 May;72(5):376–388. [PubMed] [Google Scholar]
  192. Sabin A. B. Nature of Inherited Resistance to Viruses Affecting the Nervous System. Proc Natl Acad Sci U S A. 1952 Jun;38(6):540–546. doi: 10.1073/pnas.38.6.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  193. Sabin A. B., Schlesinger R. W. PRODUCTION OF IMMUNITY TO DENGUE WITH VIRUS MODIFIED BY PROPAGATION IN MICE. Science. 1945 Jun 22;101(2634):640–642. doi: 10.1126/science.101.2634.640. [DOI] [PubMed] [Google Scholar]
  194. Sahaphong S., Riengrojpitak S., Bhamarapravati N., Chirachariyavej T. Electron microscopic study of the vascular endothelial cell in dengue hemorrhagic fever. Southeast Asian J Trop Med Public Health. 1980 Jun;11(2):194–204. [PubMed] [Google Scholar]
  195. Saiki R. K., Gelfand D. H., Stoffel S., Scharf S. J., Higuchi R., Horn G. T., Mullis K. B., Erlich H. A. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science. 1988 Jan 29;239(4839):487–491. doi: 10.1126/science.2448875. [DOI] [PubMed] [Google Scholar]
  196. Saluzzo J. F., Cornet M., Adam C., Eyraud M., Digoutte J. P. Dengue 2 au Sénégal oriental: enquête sérologique dans les populations simiennes et humaines. 1974-1985. Bull Soc Pathol Exot Filiales. 1986;79(3):313–322. [PubMed] [Google Scholar]
  197. Scherer W. F., Russell P. K., Rosen L., Casals J., Dickerman R. W. Experimental infection of chimpanzees with dengue viruses. Am J Trop Med Hyg. 1978 May;27(3):590–599. doi: 10.4269/ajtmh.1978.27.590. [DOI] [PubMed] [Google Scholar]
  198. Schlesinger J. J., Brandriss M. W., Walsh E. E. Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48. J Immunol. 1985 Oct;135(4):2805–2809. [PubMed] [Google Scholar]
  199. Schlesinger J. J., Brandriss M. W., Walsh E. E. Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1. J Gen Virol. 1987 Mar;68(Pt 3):853–857. doi: 10.1099/0022-1317-68-3-853. [DOI] [PubMed] [Google Scholar]
  200. Scott R. M., Eckels K. H., Bancroft W. H., Summers P. L., McCown J. M., Anderson J. H., Russell P. K. Dengue 2 vaccine: dose response in volunteers in relation to yellow fever immune status. J Infect Dis. 1983 Dec;148(6):1055–1060. doi: 10.1093/infdis/148.6.1055. [DOI] [PubMed] [Google Scholar]
  201. Scott R. M., Nimmannitya S., Bancroft W. H., Mansuwan P. Shock syndrome in primary dengue infections. Am J Trop Med Hyg. 1976 Nov;25(6):866–874. doi: 10.4269/ajtmh.1976.25.866. [DOI] [PubMed] [Google Scholar]
  202. Scott R. M., Nisalak A., Cheamudon U., Seridhoranakul S., Nimmannitya S. Isolation of dengue viruses from peripheral blood leukocytes of patients with hemorrhagic fever. J Infect Dis. 1980 Jan;141(1):1–6. doi: 10.1093/infdis/141.1.1. [DOI] [PubMed] [Google Scholar]
  203. Shapiro D., Brandt W. E., Cardiff R. D., Russell P. K. The proteins of Japanese encephalitis virus. Virology. 1971 Apr;44(1):108–124. doi: 10.1016/0042-6822(71)90158-9. [DOI] [PubMed] [Google Scholar]
  204. Shapiro D., Brandt W. E., Russell P. K. Change involving a viral membrane glycoprotein during morphogenesis of group B arboviruses. Virology. 1972 Dec;50(3):906–911. doi: 10.1016/0042-6822(72)90445-x. [DOI] [PubMed] [Google Scholar]
  205. Shimazu Y., Aoki H., Hotta S. Research on dengue in tissue culture. II. Further observations on virus-tissue culture affinity. Kobe J Med Sci. 1966 Dec;12(4):189–198. [PubMed] [Google Scholar]
  206. Sinarachatanant P., Olson L. C. Replication of dengue virus type 2 in Aedes albopictus cell culture. J Virol. 1973 Aug;12(2):275–283. doi: 10.1128/jvi.12.2.275-283.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  207. Speight G., Coia G., Parker M. D., Westaway E. G. Gene mapping and positive identification of the non-structural proteins NS2A, NS2B, NS3, NS4B and NS5 of the flavivirus Kunjin and their cleavage sites. J Gen Virol. 1988 Jan;69(Pt 1):23–34. doi: 10.1099/0022-1317-69-1-23. [DOI] [PubMed] [Google Scholar]
  208. Speight G., Westaway E. G. Positive identification of NS4A, the last of the hypothetical nonstructural proteins of flaviviruses. Virology. 1989 May;170(1):299–301. doi: 10.1016/0042-6822(89)90383-8. [DOI] [PubMed] [Google Scholar]
  209. Spence L., Jonkers A. H., Casals J. Dengue type 3 virus isolated from an antiguan patient during the 1963-64 Caribbean epidemic. Am J Trop Med Hyg. 1969 Jul;18(4):584–587. doi: 10.4269/ajtmh.1969.18.584. [DOI] [PubMed] [Google Scholar]
  210. Stollar V., Stevens T. M., Schlesinger R. W. Studies on the nature of dengue viruses. II. Characterization of viral RNA and effects of inhibitors of RNA synthesis. Virology. 1966 Oct;30(2):303–312. doi: 10.1016/0042-6822(66)90105-x. [DOI] [PubMed] [Google Scholar]
  211. Stollar V. Studies on the nature of dengue viruses. IV. The structural proteins of type 2 dengue virus. Virology. 1969 Nov;39(3):426–438. doi: 10.1016/0042-6822(69)90091-9. [DOI] [PubMed] [Google Scholar]
  212. Sumarmo, Wulur H., Jahja E., Gubler D. J., Suharyono W., Sorensen K. Clinical observations on virologically confirmed fatal dengue infections in Jakarta, Indonesia. Bull World Health Organ. 1983;61(4):693–701. [PMC free article] [PubMed] [Google Scholar]
  213. Sumiyoshi H., Mori C., Fuke I., Morita K., Kuhara S., Kondou J., Kikuchi Y., Nagamatu H., Igarashi A. Complete nucleotide sequence of the Japanese encephalitis virus genome RNA. Virology. 1987 Dec;161(2):497–510. doi: 10.1016/0042-6822(87)90144-9. [DOI] [PubMed] [Google Scholar]
  214. Summers P. L., Cohen W. H., Ruiz M. M., Hase T., Eckels K. H. Flaviviruses can mediate fusion from without in Aedes albopictus mosquito cell cultures. Virus Res. 1989 Apr;12(4):383–392. doi: 10.1016/0168-1702(89)90095-6. [DOI] [PubMed] [Google Scholar]
  215. Svitkin Y. V., Lyapustin V. N., Lashkevich V. A., Agol V. I. Differences between translation products of tick-borne encephalitis virus RNA in cell-free systems from Krebs-2 cells and rabbit reticulocytes: involvement of membranes in the processing of nascent precursors of flavivirus structural proteins. Virology. 1984 Jun;135(2):536–541. doi: 10.1016/0042-6822(84)90207-1. [DOI] [PubMed] [Google Scholar]
  216. Takeda H., Oya A., Hashimoto K., Yasuda T., Yamada M. A. Association of virus specific replicative ribonucleic acid with nuclear membrane in chick embryo cells infected with japanese encephalitis virus. J Gen Virol. 1978 Feb;38(2):281–291. doi: 10.1099/0022-1317-38-2-281. [DOI] [PubMed] [Google Scholar]
  217. Tan C. H., Yap E. H., Singh M., Deubel V., Chan Y. C. Passive protection studies in mice with monoclonal antibodies directed against the non-structural protein NS3 of dengue 1 virus. J Gen Virol. 1990 Mar;71(Pt 3):745–749. doi: 10.1099/0022-1317-71-3-745. [DOI] [PubMed] [Google Scholar]
  218. Tesh R. B. A method for the isolation and identification of dengue viruses, using mosquito cell cultures. Am J Trop Med Hyg. 1979 Nov;28(6):1053–1059. doi: 10.4269/ajtmh.1979.28.1053. [DOI] [PubMed] [Google Scholar]
  219. Trent D. W., Grant J. A., Monath T. P., Manske C. L., Corina M., Fox G. E. Genetic variation and microevolution of dengue 2 virus in Southeast Asia. Virology. 1989 Oct;172(2):523–535. doi: 10.1016/0042-6822(89)90195-5. [DOI] [PubMed] [Google Scholar]
  220. Trent D. W., Grant J. A., Rosen L., Monath T. P. Genetic variation among dengue 2 viruses of different geographic origin. Virology. 1983 Jul 30;128(2):271–284. doi: 10.1016/0042-6822(83)90255-6. [DOI] [PubMed] [Google Scholar]
  221. Trent D. W., Kinney R. M., Johnson B. J., Vorndam A. V., Grant J. A., Deubel V., Rice C. M., Hahn C. Partial nucleotide sequence of St. Louis encephalitis virus RNA: structural proteins, NS1, ns2a, and ns2b. Virology. 1987 Feb;156(2):293–304. doi: 10.1016/0042-6822(87)90409-0. [DOI] [PubMed] [Google Scholar]
  222. Vezza A. C., Rosen L., Repik P., Dalrymple J., Bishop D. H. Characterization of the viral RNA species of prototype dengue viruses. Am J Trop Med Hyg. 1980 Jul;29(4):643–652. doi: 10.4269/ajtmh.1980.29.643. [DOI] [PubMed] [Google Scholar]
  223. Walker P. J., Henchal E. A., Blok J., Repik P. M., Henchal L. S., Burke D. S., Robbins S. J., Gorman B. M. Variation in dengue type 2 viruses isolated in Bangkok during 1980. J Gen Virol. 1988 Mar;69(Pt 3):591–602. doi: 10.1099/0022-1317-69-3-591. [DOI] [PubMed] [Google Scholar]
  224. Wengler G., Wengler G. Cell-associated West Nile flavivirus is covered with E+pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release. J Virol. 1989 Jun;63(6):2521–2526. doi: 10.1128/jvi.63.6.2521-2526.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  225. Wengler G., Wengler G., Gross H. J. Studies on virus-specific nucleic acids synthesized in vertebrate and mosquito cells infected with flaviviruses. Virology. 1978 Sep;89(2):423–437. doi: 10.1016/0042-6822(78)90185-x. [DOI] [PubMed] [Google Scholar]
  226. Wengler G., Wengler G., Nowak T., Wahn K. Analysis of the influence of proteolytic cleavage on the structural organization of the surface of the West Nile flavivirus leads to the isolation of a protease-resistant E protein oligomer from the viral surface. Virology. 1987 Sep;160(1):210–219. doi: 10.1016/0042-6822(87)90062-6. [DOI] [PubMed] [Google Scholar]
  227. Westaway E. G., Brinton M. A., Gaidamovich SYa, Horzinek M. C., Igarashi A., Käriäinen L., Lvov D. K., Porterfield J. S., Russell P. K., Trent D. W. Flaviviridae. Intervirology. 1985;24(4):183–192. doi: 10.1159/000149642. [DOI] [PubMed] [Google Scholar]
  228. Westaway E. G. Proteins specified by group B togaviruses in mammalian cells during productive infections. Virology. 1973 Feb;51(2):454–465. doi: 10.1016/0042-6822(73)90444-3. [DOI] [PubMed] [Google Scholar]
  229. Westaway E. G. Strategy of the flavivirus genome: evidence for multiple internal initiation of translation of proteins specified by Kunjin virus in mammalian cells. Virology. 1977 Jul 15;80(2):320–335. doi: 10.1016/s0042-6822(77)80008-1. [DOI] [PubMed] [Google Scholar]
  230. White J., Matlin K., Helenius A. Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses. J Cell Biol. 1981 Jun;89(3):674–679. doi: 10.1083/jcb.89.3.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
  231. Whitehead R. H., Chaicumpa V., Olson L. C., Russell P. K. Sequential dengue virus infections in the white-handed gibbon (Hylobates lar). Am J Trop Med Hyg. 1970 Jan;19(1):94–102. doi: 10.4269/ajtmh.1970.19.94. [DOI] [PubMed] [Google Scholar]
  232. Winkler G., Heinz F. X., Kunz C. Characterization of a disulphide bridge-stabilized antigenic domain of tick-borne encephalitis virus structural glycoprotein. J Gen Virol. 1987 Aug;68(Pt 8):2239–2244. doi: 10.1099/0022-1317-68-8-2239. [DOI] [PubMed] [Google Scholar]
  233. Winkler G., Maxwell S. E., Ruemmler C., Stollar V. Newly synthesized dengue-2 virus nonstructural protein NS1 is a soluble protein but becomes partially hydrophobic and membrane-associated after dimerization. Virology. 1989 Jul;171(1):302–305. doi: 10.1016/0042-6822(89)90544-8. [DOI] [PubMed] [Google Scholar]
  234. Winkler G., Randolph V. B., Cleaves G. R., Ryan T. E., Stollar V. Evidence that the mature form of the flavivirus nonstructural protein NS1 is a dimer. Virology. 1988 Jan;162(1):187–196. doi: 10.1016/0042-6822(88)90408-4. [DOI] [PubMed] [Google Scholar]
  235. Wisseman C. L., Jr, Kitaoka M., Tamiya T. Immunological studies with group B arthropod-borne viruses. V. Evaluation of cross-immunity against type 1 dengue fever in human subjects convalescent from subclinical natural Japanese encephalitis virus infection and vaccinated with 17D strain yellow fever vaccine. Am J Trop Med Hyg. 1966 Jul;15(4):588–600. [PubMed] [Google Scholar]
  236. Yuwono J., Suharyono W., Koiman I., Tsuchiya Y., Tagaya I. Seroepidemiological survey on dengue and Japanese encephalitis virus infections in Asian monkeys. Southeast Asian J Trop Med Public Health. 1984 Jun;15(2):194–200. [PubMed] [Google Scholar]
  237. Zhang Y. M., Hayes E. P., McCarty T. C., Dubois D. R., Summers P. L., Eckels K. H., Chanock R. M., Lai C. J. Immunization of mice with dengue structural proteins and nonstructural protein NS1 expressed by baculovirus recombinant induces resistance to dengue virus encephalitis. J Virol. 1988 Aug;62(8):3027–3031. doi: 10.1128/jvi.62.8.3027-3031.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  238. Zhao B. T., Prince G., Horswood R., Eckels K., Summers P., Chanock R., Lai C. J. Expression of dengue virus structural proteins and nonstructural protein NS1 by a recombinant vaccinia virus. J Virol. 1987 Dec;61(12):4019–4022. doi: 10.1128/jvi.61.12.4019-4022.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  239. Zhao B., Mackow E., Buckler-White A., Markoff L., Chanock R. M., Lai C. J., Makino Y. Cloning full-length dengue type 4 viral DNA sequences: analysis of genes coding for structural proteins. Virology. 1986 Nov;155(1):77–88. doi: 10.1016/0042-6822(86)90169-8. [DOI] [PubMed] [Google Scholar]
  240. de Andino R. M., Botet M. V., Gubler D. J., García C., Laboy E., Espada F., Waterman S. H. The absence of dengue virus in the skin lesions of dengue fever. Int J Dermatol. 1985 Jan-Feb;24(1):48–51. doi: 10.1111/j.1365-4362.1985.tb05360.x. [DOI] [PubMed] [Google Scholar]

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