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. 1992 Apr;5(2):204–210. doi: 10.1128/cmr.5.2.204

Nonpulmonary manifestations of cytomegalovirus infection in immunocompromised patients.

W L Drew 1
PMCID: PMC358235  PMID: 1315617

Abstract

Nonpulmonary manifestations of cytomegalovirus (CMV) infection in immunocompromised patients include chorioretinitis, gastrointestinal infection, and central nervous system disease. Diagnosis of end organ disease, especially in the gastrointestinal tract, is best substantiated by histologic evidence of CMV inclusions. Positive cultures of CMV provide evidence for supporting infection but do not define actual end organ disease. Satisfactory treatment of the disease can be accomplished with ganciclovir or foscarnet, although these agents only suppress virus replication. In many instances, severe CMV-induced end organ disease in immunocompromised patients will progress despite treatment. In some instances, resistance to the antiviral agent is the basis for drug failure. Patients at high risk for CMV disease can be identified, and studies of prophylaxis are in progress.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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