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. 1994 Oct;7(4):479–504. doi: 10.1128/cmr.7.4.479

Taxonomy, biology, and clinical aspects of Fusarium species.

P E Nelson 1, M C Dignani 1, E J Anaissie 1
PMCID: PMC358338  PMID: 7834602

Abstract

There are several taxonomic systems available for identifying Fusarium species. The philosophy used in each taxonomic system is discussed as well as problems encountered in working with Fusarium species in culture. Fusarium species are toxigenic, and the mycotoxins produced by these organisms are often associated with animal and human diseases. The implications for the association of the carcinogens, fumonisins, produced by Fusarium moniliforme and other Fusarium species with human diseases are discussed. Foreign-body-associated fusarial infection such as keratitis in contact lens wearers, onychomycosis, skin infections, and disseminated multiorgan infections are discussed. Disseminated fusarial hyalohyphomycosis has emerged as a significant, usually fatal infection in the immunocompromised host. Successful outcome is determined by the degree of immunosuppression, the extent of the infection, and the presence of a removable focus such as an indwelling central venous catheter. These infections may be clinically suspected on the basis of a constellation of clinical and laboratory findings, which should lead to prompt therapy, probably with one of the newer antifungal agents. Perhaps the use of such agents or the use of colony-stimulating factors may improve the outcome of this devastating infection. However, until new approaches for treatment develop, effective preventive measures are urgently needed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abramowsky C. R., Quinn D., Bradford W. D., Conant N. F. Systemic infection by fusarium in a burned child. The emergence of a saprophytic strain. J Pediatr. 1974 Apr;84(4):561–564. doi: 10.1016/s0022-3476(74)80681-5. [DOI] [PubMed] [Google Scholar]
  2. Adetosoye A. I., Adene D. F. The response of chickens to experimental infection with Fusarium spp. Bull Anim Health Prod Afr. 1978 Jun;26(2):198–120. [PubMed] [Google Scholar]
  3. Alvarez-Franco M., Reyes-Mugica M., Paller A. S. Cutaneous Fusarium infection in an adolescent with acute leukemia. Pediatr Dermatol. 1992 Mar;9(1):62–65. doi: 10.1111/j.1525-1470.1992.tb00328.x. [DOI] [PubMed] [Google Scholar]
  4. Anaissie E. J., Hachem R., Legrand C., Legenne P., Nelson P., Bodey G. P. Lack of activity of amphotericin B in systemic murine fusarial infection. J Infect Dis. 1992 Jun;165(6):1155–1157. [PubMed] [Google Scholar]
  5. Anaissie E. J., Kontoyiannis D. P., Vartivarian S., Kantarjian H. M., O'Brien S., Giralt S. A., Andersson B. S., Karl C., Champlin R. E., Bodey G. P. Effectiveness of an oral triazole for opportunistic mold infections in patients with cancer: experience with SCH 39304. Clin Infect Dis. 1993 Dec;17(6):1022–1031. doi: 10.1093/clinids/17.6.1022. [DOI] [PubMed] [Google Scholar]
  6. Anaissie E., Kantarjian H., Jones P., Barlogie B., Luna M., Lopez-Berestein G., Bodey G. P. Fusarium. A newly recognized fungal pathogen in immunosuppressed patients. Cancer. 1986 Jun 1;57(11):2141–2145. doi: 10.1002/1097-0142(19860601)57:11<2141::aid-cncr2820571110>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  7. Anaissie E., Nelson P., Beremand M., Kontoyiannis D., Rinaldi M. Fusarium-caused hyalohyphomycosis: an overview. Curr Top Med Mycol. 1992;4:231–249. doi: 10.1007/978-1-4612-2762-5_9. [DOI] [PubMed] [Google Scholar]
  8. Ando N., Takatori K. Fungal flora of the conjunctival sac. Am J Ophthalmol. 1982 Jul;94(1):67–74. doi: 10.1016/0002-9394(82)90193-3. [DOI] [PubMed] [Google Scholar]
  9. Attapattu M. C., Anandakrishnan C. Extensive subcutaneous hyphomycosis caused by Fusarium oxysporum. J Med Vet Mycol. 1986 Apr;24(2):105–111. [PubMed] [Google Scholar]
  10. BURDA C. D., FISHER E., Jr The use of cortisone in establishing experimental fungal keratitis in rats: a preliminary report. Am J Ophthalmol. 1959 Sep;48(3):330–335. [PubMed] [Google Scholar]
  11. Bacon S. P. Effect of masker level on overshoot. J Acoust Soc Am. 1990 Aug;88(2):698–702. doi: 10.1121/1.399773. [DOI] [PubMed] [Google Scholar]
  12. Barrios N. J., Kirkpatrick D. V., Murciano A., Stine K., Van Dyke R. B., Humbert J. R. Successful treatment of disseminated Fusarium infection in an immunocompromised child. Am J Pediatr Hematol Oncol. 1990 Fall;12(3):319–324. doi: 10.1097/00043426-199023000-00013. [DOI] [PubMed] [Google Scholar]
  13. Baudraz-Rosselet F., Monod M., Borradori L., Ginalsky J. M., Vion B., Boccard C., Frenk E. Mycetoma of the foot due to Fusarium sp. treated with oral ketoconazole. Dermatology. 1992;184(4):303–305. doi: 10.1159/000247578. [DOI] [PubMed] [Google Scholar]
  14. Becker W. K., Cioffi W. G., Jr, McManus A. T., Kim S. H., McManus W. F., Mason A. D., Pruitt B. A., Jr Fungal burn wound infection. A 10-year experience. Arch Surg. 1991 Jan;126(1):44–48. doi: 10.1001/archsurg.1991.01410250048008. [DOI] [PubMed] [Google Scholar]
  15. Benjamin R. P., Callaway L., Conant N. F. Facial granuloma associated with fusarium infection. Arch Dermatol. 1970 May;101(5):598–600. [PubMed] [Google Scholar]
  16. Bhat R. V., Beedu S. R., Ramakrishna Y., Munshi K. L. Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat production in Kashmir Valley, India. Lancet. 1989 Jan 7;1(8628):35–37. doi: 10.1016/s0140-6736(89)91684-x. [DOI] [PubMed] [Google Scholar]
  17. Bhavanishankar T. N., Ramesh H. P., Shantha T. Dermal toxicity of Fusarium toxins in combinations. Arch Toxicol. 1988 Jan;61(3):241–244. doi: 10.1007/BF00316641. [DOI] [PubMed] [Google Scholar]
  18. Bjeldanes L. F., Thomson S. V. Mutagenic activity of Fusarium moniliforme isolates in the Salmonella typhimurium assay. Appl Environ Microbiol. 1979 Jun;37(6):1118–1121. doi: 10.1128/aem.37.6.1118-1121.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Blazar B. R., Hurd D. D., Snover D. C., Alexander J. W., McGlave P. B. Invasive Fusarium infections in bone marrow transplant recipients. Am J Med. 1984 Oct;77(4):645–651. doi: 10.1016/0002-9343(84)90355-3. [DOI] [PubMed] [Google Scholar]
  20. Bourguignon R. L., Walsh A. F., Flynn J. C., Baro C., Spinos E. Fusarium species osteomyelitis. Case report. J Bone Joint Surg Am. 1976 Jul;58(5):722–723. [PubMed] [Google Scholar]
  21. Caplin I., Unger D. L. Molds on the Southern California deserts. Ann Allergy. 1983 Apr;50(4):260–263. [PubMed] [Google Scholar]
  22. Charles A. M., Callender M., Grosvenor T. Efficacy of chemical asepticizing system for soft contact lenses. Am J Optom Arch Am Acad Optom. 1973 Oct;50(10):777–781. doi: 10.1097/00006324-197310000-00002. [DOI] [PubMed] [Google Scholar]
  23. Chiaradia V., Schinella D., Pascoli L., Tesio F., Santini G. F. Fusarium peritonitis in peritoneal dialysis: report of two cases. Microbiologica. 1990 Jan;13(1):77–78. [PubMed] [Google Scholar]
  24. Cho C. T., Vats T. S., Lowman J. T., Brandsberg J. W., Tosh F. E. Fusarium solani infection during treatment for acute leukemia. J Pediatr. 1973 Dec;83(6):1028–1031. doi: 10.1016/s0022-3476(73)80543-8. [DOI] [PubMed] [Google Scholar]
  25. Clark S. C., Kamen R. The human hematopoietic colony-stimulating factors. Science. 1987 Jun 5;236(4806):1229–1237. doi: 10.1126/science.3296190. [DOI] [PubMed] [Google Scholar]
  26. Cohen R., Roth F. J., Delgado E., Ahearn D. G., Kalser M. H. Fungal flora of the normal human small and large intestine. N Engl J Med. 1969 Mar 20;280(12):638–641. doi: 10.1056/NEJM196903202801204. [DOI] [PubMed] [Google Scholar]
  27. Cole R. J., Kirksey J. W., Cutler H. G., Doupnik B. L., Peckham J. C. Toxin from Fusarium moniliforme: Effects on Plants and Animals. Science. 1973 Mar 30;179(4080):1324–1326. doi: 10.1126/science.179.4080.1324. [DOI] [PubMed] [Google Scholar]
  28. Collins M. S., Rinaldi M. G. Cutaneous infection in man caused by Fusarium moniliforme. Sabouraudia. 1977 Jul;15(2):151–160. [PubMed] [Google Scholar]
  29. Doerr J. A., Huff W. E., Tung H. T., Wyatt R. D., Hamilton P. B. A survey of T-2 toxin, ochratoxin, and aflatoxin for their effects on the coagulation of blood in young broiler chickens. Poult Sci. 1974 Sep;53(5):1728–1734. doi: 10.3382/ps.0531728. [DOI] [PubMed] [Google Scholar]
  30. Donzis P. B., Mondino B. J., Weissman B. A., Bruckner D. A. Microbial contamination of contact lens care systems. Am J Ophthalmol. 1987 Oct 15;104(4):325–333. doi: 10.1016/0002-9394(87)90219-4. [DOI] [PubMed] [Google Scholar]
  31. Durán J. A., Malvar A., Pereiro M., Pereiro M. Fusarium moniliforme keratitis. Acta Ophthalmol (Copenh) 1989 Dec;67(6):710–713. doi: 10.1111/j.1755-3768.1989.tb04406.x. [DOI] [PubMed] [Google Scholar]
  32. English M. P. Invasion of the skin by filamentous non-dermatophyte fungi. Br J Dermatol. 1968 May;80(5):282–286. doi: 10.1111/j.1365-2133.1968.tb12300.x. [DOI] [PubMed] [Google Scholar]
  33. English M. P., Smith R. J., Harman R. R. The fungal flora of ulcerated legs. Br J Dermatol. 1971 Jun;84(6):567–581. doi: 10.1111/j.1365-2133.1971.tb02546.x. [DOI] [PubMed] [Google Scholar]
  34. Fitzsimons R., Peters A. L. Miconazole and ketoconazole as a satisfactory first-line treatment for keratomycosis. Am J Ophthalmol. 1986 May 15;101(5):605–608. doi: 10.1016/0002-9394(86)90953-0. [DOI] [PubMed] [Google Scholar]
  35. Forsell J. H., Witt M. F., Tai J. H., Jensen R., Pestka J. J. Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone. Food Chem Toxicol. 1986 Mar;24(3):213–219. doi: 10.1016/0278-6915(86)90231-0. [DOI] [PubMed] [Google Scholar]
  36. Forster R. K., Rebell G. Animal model of Fusarium solani keratitis. Am J Ophthalmol. 1975 Mar;79(3):510–515. doi: 10.1016/0002-9394(75)90629-7. [DOI] [PubMed] [Google Scholar]
  37. Friend S. C., Babiuk L. A., Schiefer H. B. The effects of dietary T-2 toxin on the immunological function and herpes simplex reactivation in Swiss mice. Toxicol Appl Pharmacol. 1983 Jun 30;69(2):234–244. doi: 10.1016/0041-008x(83)90304-6. [DOI] [PubMed] [Google Scholar]
  38. Fromentin H., Salazar-Mejicanos S., Mariat F. Experimental cryptococcosis in mice treated with diacetoxyscirpenol, a mycotoxin of fusarium. Sabouraudia. 1981 Dec;19(4):311–313. doi: 10.1080/00362178185380501. [DOI] [PubMed] [Google Scholar]
  39. Gamis A. S., Gudnason T., Giebink G. S., Ramsay N. K. Disseminated infection with Fusarium in recipients of bone marrow transplants. Rev Infect Dis. 1991 Nov-Dec;13(6):1077–1088. doi: 10.1093/clinids/13.6.1077. [DOI] [PubMed] [Google Scholar]
  40. Gelderblom W. C., Jaskiewicz K., Marasas W. F., Thiel P. G., Horak R. M., Vleggaar R., Kriek N. P. Fumonisins--novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl Environ Microbiol. 1988 Jul;54(7):1806–1811. doi: 10.1128/aem.54.7.1806-1811.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Gelderblom W. C., Kriek N. P., Marasas W. F., Thiel P. G. Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. Carcinogenesis. 1991 Jul;12(7):1247–1251. doi: 10.1093/carcin/12.7.1247. [DOI] [PubMed] [Google Scholar]
  42. Gelderblom W. C., Thiel P. G., Jaskiewicz K., Marasas W. F. Investigations on the carcinogenicity of fusarin C--a mutagenic metabolite of Fusarium moniliforme. Carcinogenesis. 1986 Nov;7(11):1899–1901. doi: 10.1093/carcin/7.11.1899. [DOI] [PubMed] [Google Scholar]
  43. Gelderblom W. C., Thiel P. G., van der Merwe K. J., Marasas W. F., Spies H. S. A mutagen produced by Fusarium moniliforme. Toxicon. 1983;21(4):467–473. doi: 10.1016/0041-0101(83)90124-1. [DOI] [PubMed] [Google Scholar]
  44. Gerberick G. F., Sorenson W. G. Toxicity of T-2 toxin, a Fusarium mycotoxin, to alveolar macrophages in vitro. Environ Res. 1983 Dec;32(2):269–285. doi: 10.1016/0013-9351(83)90111-1. [DOI] [PubMed] [Google Scholar]
  45. Girmenia C., Arcese W., Micozzi A., Martino P., Bianco P., Morace G. Onychomycosis as a possible origin of disseminated Fusarium solani infection in a patient with severe aplastic anemia. Clin Infect Dis. 1992 May;14(5):1167–1167. doi: 10.1093/clinids/14.5.1167. [DOI] [PubMed] [Google Scholar]
  46. Gradon J. D., Lerman A., Lutwick L. I. Septic arthritis due to Fusarium moniliforme. Rev Infect Dis. 1990 Jul-Aug;12(4):716–717. doi: 10.1093/clinids/12.4.716. [DOI] [PubMed] [Google Scholar]
  47. Harrison L. R., Colvin B. M., Greene J. T., Newman L. E., Cole J. R., Jr Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. J Vet Diagn Invest. 1990 Jul;2(3):217–221. doi: 10.1177/104063879000200312. [DOI] [PubMed] [Google Scholar]
  48. Haschek W. M., Motelin G., Ness D. K., Harlin K. S., Hall W. F., Vesonder R. F., Peterson R. E., Beasley V. R. Characterization of fumonisin toxicity in orally and intravenously dosed swine. Mycopathologia. 1992 Feb;117(1-2):83–96. doi: 10.1007/BF00497283. [DOI] [PubMed] [Google Scholar]
  49. Hatherill J. R., Till G. O., Bruner L. H., Ward P. A. Thermal injury, intravascular hemolysis, and toxic oxygen products. J Clin Invest. 1986 Sep;78(3):629–636. doi: 10.1172/JCI112620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Hay R. J., Mackenzie D. W. Mycetoma (madura foot) in the United Kingdom--a survey of forty-four cases. Clin Exp Dermatol. 1983 Sep;8(5):553–562. doi: 10.1111/j.1365-2230.1983.tb01823.x. [DOI] [PubMed] [Google Scholar]
  51. Helm T. N., Longworth D. L., Hall G. S., Bolwell B. J., Fernandez B., Tomecki K. J. Case report and review of resolved fusariosis. J Am Acad Dermatol. 1990 Aug;23(2 Pt 2):393–398. doi: 10.1016/0190-9622(90)70231-6. [DOI] [PubMed] [Google Scholar]
  52. Hemo I., Pe'er J., Polacheck I. Fusarium oxysporum keratitis. Ophthalmologica. 1989;198(1):3–7. doi: 10.1159/000309951. [DOI] [PubMed] [Google Scholar]
  53. Jakle C., Leek J. C., Olson D. A., Robbins D. L. Septic arthritis due to Fusarium solani. J Rheumatol. 1983 Feb;10(1):151–153. [PubMed] [Google Scholar]
  54. Joffe A. Z. A modern system of Fusarium taxonomy. Mycopathol Mycol Appl. 1974 Aug 30;53(1):201–228. doi: 10.1007/BF02127209. [DOI] [PubMed] [Google Scholar]
  55. Joffe A. Z. Environmental conditions conducive to Fusarium toxin formation causing serious outbreaks in animals and man. Vet Res Commun. 1983 Dec;7(1-4):187–193. doi: 10.1007/BF02228615. [DOI] [PubMed] [Google Scholar]
  56. Jones B. R., Jones D. B., Lim A. S., Bron A. J., Morgan G., Clayton Y. M. Corneal and intra-ocular infection due to Fusarium solani. Trans Ophthalmol Soc U K. 1970;89:757–779. [PubMed] [Google Scholar]
  57. Jones D. B., Forster F. K., Rebell G. Fusarium solani keratitis treated with natamycin (pimaricin): eighteen consecutive cases. Arch Ophthalmol. 1972 Aug;88(2):147–154. doi: 10.1001/archopht.1972.01000030149004. [DOI] [PubMed] [Google Scholar]
  58. Jones D. B. Pathogenesis of bacterial and fungal keratitis. Trans Ophthalmol Soc U K. 1978 Sep;98(3):367–371. [PubMed] [Google Scholar]
  59. Jones D. B., Sexton R., Rebell G. Mycotic keratitis in South Florida: a review of thirty-nine cases. Trans Ophthalmol Soc U K. 1970;89:781–797. [PubMed] [Google Scholar]
  60. Kellerman T. S., Marasas W. F., Thiel P. G., Gelderblom W. C., Cawood M., Coetzer J. A. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort J Vet Res. 1990 Dec;57(4):269–275. [PubMed] [Google Scholar]
  61. Kerr C. M., Perfect J. R., Craven P. C., Jorgensen J. H., Drutz D. J., Shelburne J. D., Gallis H. A., Gutman R. A. Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. Ann Intern Med. 1983 Sep;99(3):334–336. doi: 10.7326/0003-4819-99-3-334. [DOI] [PubMed] [Google Scholar]
  62. Khairallah S. H., Byrne K. A., Tabbara K. F. Fungal keratitis in Saudi Arabia. Doc Ophthalmol. 1992;79(3):269–276. doi: 10.1007/BF00158257. [DOI] [PubMed] [Google Scholar]
  63. Kiehn T. E., Nelson P. E., Bernard E. M., Edwards F. F., Koziner B., Armstrong D. Catheter-associated fungemia caused by Fusarium chlamydosporum in a patient with lymphocytic lymphoma. J Clin Microbiol. 1985 Apr;21(4):501–504. doi: 10.1128/jcm.21.4.501-504.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Kiryu H., Yoshida S., Suenaga Y., Asahi M. Invasion and survival of Fusarium solani in the dexamethasone-treated cornea of rabbits. J Med Vet Mycol. 1991;29(6):395–406. [PubMed] [Google Scholar]
  65. Kombila M., Gomez de Diaz M., de Bièvre C., Crepet G., Debrie J. C., Belembaogo E., Richard-Lenoble D. Les otites mycosiques à Libreville. Etude de 83 cas. Bull Soc Pathol Exot Filiales. 1989;82(2):201–207. [PubMed] [Google Scholar]
  66. Kriek N. P., Kellerman T. S., Marasas W. F. A comparative study of the toxicity of Fusarium verticillioides (= F. moniliforme) to horses, primates, pigs, sheep and rats. Onderstepoort J Vet Res. 1981 Jun;48(2):129–131. [PubMed] [Google Scholar]
  67. Kriek N. P., Marasas W. F., Thiel P. G. Hepato- and cardiotoxicity of Fusarium verticillioides (F. moniliforme) isolates from Southern African maize. Food Cosmet Toxicol. 1981 Aug;19(4):447–456. doi: 10.1016/0015-6264(81)90449-1. [DOI] [PubMed] [Google Scholar]
  68. Landau M., Srebrnik A., Wolf R., Bashi E., Brenner S. Systemic ketoconazole treatment for Fusarium leg ulcers. Int J Dermatol. 1992 Jul;31(7):511–512. doi: 10.1111/j.1365-4362.1992.tb02705.x. [DOI] [PubMed] [Google Scholar]
  69. Legrand C., Anaissie E., Hashem R., Nelson P., Bodey G. P., Ro J. Experimental fusarial hyalohyphomycosis in a murine model. J Infect Dis. 1991 Nov;164(5):944–948. doi: 10.1093/infdis/164.5.944. [DOI] [PubMed] [Google Scholar]
  70. Lieberman T. W., Ferry A. P., Bottone E. J. Fusarium solani endophthalmitis without primary corneal involvement. Am J Ophthalmol. 1979 Oct;88(4):764–767. doi: 10.1016/0002-9394(79)90680-9. [DOI] [PubMed] [Google Scholar]
  71. Madhavan M., Ratnakar C., Veliath A. J., Kanungo R., Smile S. R., Bhat S. Primary disseminated fusarial infection. Postgrad Med J. 1992 Feb;68(796):143–144. doi: 10.1136/pgmj.68.796.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Marasas W. F., Kellerman T. S., Gelderblom W. C., Coetzer J. A., Thiel P. G., van der Lugt J. J. Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J Vet Res. 1988 Dec;55(4):197–203. [PubMed] [Google Scholar]
  73. Marasas W. F., Kriek N. P., Fincham J. E., van Rensburg S. J. Primary liver cancer and oesophageal basal cell hyperplasia in rats caused by Fusarium moniliforme. Int J Cancer. 1984 Sep 15;34(3):383–387. doi: 10.1002/ijc.2910340315. [DOI] [PubMed] [Google Scholar]
  74. Marasas W. F., van Rensburg S. J., Mirocha C. J. Incidence of Fusarium species and the mycotoxins, deoxynivalenol and zearalenone, in corn produced in esophageal cancer areas in Transkei. J Agric Food Chem. 1979 Sep-Oct;27(5):1108–1112. doi: 10.1021/jf60225a013. [DOI] [PubMed] [Google Scholar]
  75. Matsuda T., Matsumoto T. Disseminated hyalohyphomycosis in a leukemic patient. Arch Dermatol. 1986 Oct;122(10):1171–1175. [PubMed] [Google Scholar]
  76. Merz W. G., Karp J. E., Hoagland M., Jett-Goheen M., Junkins J. M., Hood A. F. Diagnosis and successful treatment of fusariosis in the compromised host. J Infect Dis. 1988 Nov;158(5):1046–1055. doi: 10.1093/infdis/158.5.1046. [DOI] [PubMed] [Google Scholar]
  77. Minor R. L., Jr, Pfaller M. A., Gingrich R. D., Burns L. J. Disseminated Fusarium infections in patients following bone marrow transplantation. Bone Marrow Transplant. 1989 Nov;4(6):653–658. [PubMed] [Google Scholar]
  78. Miño de Kaspar H., Zoulek G., Paredes M. E., Alborno R., Medina D., Centurion de Morinigo M., Ortiz de Fresco M., Aguero F. Mycotic keratitis in Paraguay. Mycoses. 1991 May-Jun;34(5-6):251–254. doi: 10.1111/j.1439-0507.1991.tb00653.x. [DOI] [PubMed] [Google Scholar]
  79. Morel-Chany E., Burtin P., Trincal G., Frayssinet C. Cytostatic effects of T2 toxin on cultured human neoplastic cells of intestinal origin. Bull Cancer. 1980;67(2):149–154. [PubMed] [Google Scholar]
  80. Mowbray D. N., Paller A. S., Nelson P. E., Kaplan R. L. Disseminated Fusarium solani infection with cutaneous nodules in a bone marrow transplant patient. Int J Dermatol. 1988 Dec;27(10):698–701. doi: 10.1111/j.1365-4362.1988.tb01267.x. [DOI] [PubMed] [Google Scholar]
  81. Mutton K. J., Lucas T. J., Harkness J. L. Disseminated fusarium infection. Med J Aust. 1980 Nov 29;2(11):624–625. doi: 10.5694/j.1326-5377.1980.tb77068.x. [DOI] [PubMed] [Google Scholar]
  82. Nadler J. P. Disseminated fusarial infection. Rev Infect Dis. 1990 Jan-Feb;12(1):162–162. doi: 10.1093/clinids/12.1.162. [DOI] [PubMed] [Google Scholar]
  83. Nati R., Dreyfus F., Lanore J. J., Brunet F., Robin P., Bordier C., Dupouy-Camet J. Localisations cutanées d'une septicémie à Fusarium oxysporum survenant chez un patient en aplasie médullaire. Ann Dermatol Venereol. 1988;115(3):337–338. [PubMed] [Google Scholar]
  84. Nelson P. E., Plattner R. D., Shackelford D. D., Desjardins A. E. Fumonisin B1 production by Fusarium species other than F. moniliforme in section Liseola and by some related species. Appl Environ Microbiol. 1992 Mar;58(3):984–989. doi: 10.1128/aem.58.3.984-989.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Nelson P. E., Plattner R. D., Shackelford D. D., Desjardins A. E. Production of fumonisins by Fusarium moniliforme strains from various substrates and geographic areas. Appl Environ Microbiol. 1991 Aug;57(8):2410–2412. doi: 10.1128/aem.57.8.2410-2412.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  86. Nelson P. E. Taxonomy and biology of Fusarium moniliforme. Mycopathologia. 1992 Feb;117(1-2):29–36. doi: 10.1007/BF00497276. [DOI] [PubMed] [Google Scholar]
  87. Norred W. P., Wang E., Yoo H., Riley R. T., Merrill A. H., Jr In vitro toxicology of fumonisins and the mechanistic implications. Mycopathologia. 1992 Feb;117(1-2):73–78. doi: 10.1007/BF00497281. [DOI] [PubMed] [Google Scholar]
  88. Notermans S., Dufrenne J., Wijnands L. M., Engel H. W. Human serum antibodies to extracellular polysaccharides (EPS) of moulds. J Med Vet Mycol. 1988 Feb;26(1):41–48. doi: 10.1080/02681218880000051. [DOI] [PubMed] [Google Scholar]
  89. Nuovo M. A., Simmonds J. E., Chacho M. S., McKitrick J. C. Fusarium solani osteomyelitis with probable nosocomial spread. Am J Clin Pathol. 1988 Dec;90(6):738–741. doi: 10.1093/ajcp/90.6.738. [DOI] [PubMed] [Google Scholar]
  90. O'Day D. M., Akrabawi P. L., Richmond L. D., Jones B. R., Clayton Y. An animal model of Fusarium solani endophthalmitis. Br J Ophthalmol. 1979 Apr;63(4):277–280. doi: 10.1136/bjo.63.4.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. O'Day D. M., Head W. S., Robinson R. D., Clanton J. A. Corneal penetration of topical amphotericin B and natamycin. Curr Eye Res. 1986 Nov;5(11):877–882. doi: 10.3109/02713688609029240. [DOI] [PubMed] [Google Scholar]
  92. Okuda C., Ito M., Sato Y., Oka K., Hotchi M. Disseminated cutaneous Fusarium infection with vascular invasion in a leukemic patient. J Med Vet Mycol. 1987 Jun;25(3):177–186. [PubMed] [Google Scholar]
  93. Page J. C., Friedlander G., Dockery G. L. Postoperative fusarium osteomyelitis. J Foot Surg. 1982 Fall;21(3):174–176. [PubMed] [Google Scholar]
  94. Patoux-Pibouin M., Couatarmanach A., Le Gall F., Bergeron C., De Bièvre C., Guiguen C., Chevrant-Breton J. Fusariose à Fusarium solani chez un adolescent leucémique. Ann Dermatol Venereol. 1992;119(5):377–380. [PubMed] [Google Scholar]
  95. Patterson J. W., Brown P. C., Broecker A. H. Infection-induced panniculitis. J Cutan Pathol. 1989 Aug;16(4):183–193. doi: 10.1111/j.1600-0560.1989.tb00038.x. [DOI] [PubMed] [Google Scholar]
  96. Pestka J. J., Tai J. H., Witt M. F., Dixon D. E., Forsell J. H. Suppression of immune response in the B6C3F1 mouse after dietary exposure to the Fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone. Food Chem Toxicol. 1987 Apr;25(4):297–304. doi: 10.1016/0278-6915(87)90126-8. [DOI] [PubMed] [Google Scholar]
  97. Pflugfelder S. C., Flynn H. W., Jr, Zwickey T. A., Forster R. K., Tsiligianni A., Culbertson W. W., Mandelbaum S. Exogenous fungal endophthalmitis. Ophthalmology. 1988 Jan;95(1):19–30. doi: 10.1016/s0161-6420(88)33229-x. [DOI] [PubMed] [Google Scholar]
  98. Pitts R. E., Krachmer J. H. Evaluation of soft contact lens disinfection in the home environment. Arch Ophthalmol. 1979 Mar;97(3):470–472. doi: 10.1001/archopht.1979.01020010220005. [DOI] [PubMed] [Google Scholar]
  99. Plattner R. D., Shackelford D. D. Biosynthesis of labeled fumonisins in liquid cultures of Fusarium moniliforme. Mycopathologia. 1992 Feb;117(1-2):17–22. doi: 10.1007/BF00497274. [DOI] [PubMed] [Google Scholar]
  100. Pérez-Comas A., Saénz de Rodríguez C. A., Sánchez Lugo F. Anomalías de desarrollo sexual en Puerto Rico: estado de situación. Bol Asoc Med P R. 1991 Jul;83(7):306–309. [PubMed] [Google Scholar]
  101. Qureshi M. A., Hagler W. M., Jr Effect of fumonisin-B1 exposure on chicken macrophage functions in vitro. Poult Sci. 1992 Jan;71(1):104–112. doi: 10.3382/ps.0710104. [DOI] [PubMed] [Google Scholar]
  102. Raicu M. D. Infecţie diseminată cu Fusarium sp. Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1983 Jan-Mar;28(1):69–74. [PubMed] [Google Scholar]
  103. Rajasekaran J., Thomas P. A., Kalavathy C. M., Joseph P. C., Abraham D. J. Itraconazole therapy for fungal keratitis. Indian J Ophthalmol. 1987;35(5-6):157–160. [PubMed] [Google Scholar]
  104. Reuben A., Anaissie E., Nelson P. E., Hashem R., Legrand C., Ho D. H., Bodey G. P. Antifungal susceptibility of 44 clinical isolates of Fusarium species determined by using a broth microdilution method. Antimicrob Agents Chemother. 1989 Sep;33(9):1647–1649. doi: 10.1128/aac.33.9.1647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Richardson S. E., Bannatyne R. M., Summerbell R. C., Milliken J., Gold R., Weitzman S. S. Disseminated fusarial infection in the immunocompromised host. Rev Infect Dis. 1988 Nov-Dec;10(6):1171–1181. doi: 10.1093/clinids/10.6.1171. [DOI] [PubMed] [Google Scholar]
  106. Rippon J. W., Larson R. A., Rosenthal D. M., Clayman J. Disseminated cutaneous and peritoneal hyalohyphomycosis caused by Fusarium species: three cases and review of the literature. Mycopathologia. 1988 Feb;101(2):105–111. doi: 10.1007/BF00452895. [DOI] [PubMed] [Google Scholar]
  107. Robertson M. J., Socinski M. A., Soiffer R. J., Finberg R. W., Wilson C., Anderson K. C., Bosserman L., Sang D. N., Salkin I. F., Ritz J. Successful treatment of disseminated Fusarium infection after autologous bone marrow transplantation for acute myeloid leukemia. Bone Marrow Transplant. 1991 Aug;8(2):143–145. [PubMed] [Google Scholar]
  108. Rokicka-Milewska R., Derulska D., Lipnicki D., Skrobowska-Woźniak A., Moszczeńska A. The use of 2.5% natamycin, as orally administered drops, in the treatment of fungal infections of the oral cavity in children with chronic blood diseases. J Int Med Res. 1989 Jan-Feb;17(1):82–86. doi: 10.1177/030006058901700112. [DOI] [PubMed] [Google Scholar]
  109. Rosenstein Y., Kretschmer R. R., Lafarge-Frayssinet C. Effect of Fusarium toxins, T2-toxin and diacetoxyscirpenol on murine T-independent immune responses. Immunology. 1981 Nov;44(3):555–560. [PMC free article] [PubMed] [Google Scholar]
  110. Rosenstein Y., Lafarge-Frayssinet C., Lespinats G., Loisillier F., Lafont P., Frayssinet C. Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and diacetoxyscirpenol. Immunology. 1979 Jan;36(1):111–117. [PMC free article] [PubMed] [Google Scholar]
  111. Ross P. F., Nelson P. E., Richard J. L., Osweiler G. D., Rice L. G., Plattner R. D., Wilson T. M. Production of fumonisins by Fusarium moniliforme and Fusarium proliferatum isolates associated with equine leukoencephalomalacia and a pulmonary edema syndrome in swine. Appl Environ Microbiol. 1990 Oct;56(10):3225–3226. doi: 10.1128/aem.56.10.3225-3226.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Rotowa N. A., Shadomy H. J., Shadomy S. In vitro activities of polyene and imidazole antifungal agents against unusual opportunistic fungal pathogens. Mycoses. 1990 Apr;33(4):203–211. doi: 10.1111/myc.1990.33.4.203. [DOI] [PubMed] [Google Scholar]
  113. Ruben M. Preliminary observations of soft 9(hydrophilic) contact lenses. Proc R Soc Med. 1966 Jun;59(6):531–532. doi: 10.1177/003591576605900622. [DOI] [PMC free article] [PubMed] [Google Scholar]
  114. Rush-Munro F. M., Black H., Dingley J. M. Onychomycosis caused by fusarium oxysporum. Australas J Dermatol. 1971 Apr;12(1):18–29. doi: 10.1111/j.1440-0960.1971.tb00688.x. [DOI] [PubMed] [Google Scholar]
  115. Rütten A., Hantschke D., Goos M. Kutane Manifestation einer Pilzsepsis. Hautarzt. 1990 Jul;41(7):392–393. [PubMed] [Google Scholar]
  116. SNYDER W. C., HANSEN H. N. Variation and speciation in the genus Fusarium. Ann N Y Acad Sci. 1954 Oct 29;60(1):16–23. doi: 10.1111/j.1749-6632.1954.tb39994.x. [DOI] [PubMed] [Google Scholar]
  117. Salazar S., Fromentin H., Mariat F. Action du diacetoxyscirpénol sur la candidose expérimentale de la Souris. C R Seances Acad Sci D. 1980 Mar 31;290(13):877–878. [PubMed] [Google Scholar]
  118. Schneller F. R., Gulati S. C., Cunningham I. B., O'Reilly R. J., Schmitt H. J., Clarkson B. D. Fusarium infections in patients with hematologic malignancies. Leuk Res. 1990;14(11-12):961–966. doi: 10.1016/0145-2126(90)90108-l. [DOI] [PubMed] [Google Scholar]
  119. Sharman M., Gilbert J., Chelkowski J. A survey of the occurrence of the mycotoxin moniliformin in cereal samples from sources worldwide. Food Addit Contam. 1991 Jul-Aug;8(4):459–466. doi: 10.1080/02652039109373996. [DOI] [PubMed] [Google Scholar]
  120. Simmons R. B., Buffington J. R., Ward M., Wilson L. A., Ahearn D. G. Morphology and ultrastructure of fungi in extended-wear soft contact lenses. J Clin Microbiol. 1986 Jul;24(1):21–25. doi: 10.1128/jcm.24.1.21-25.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. Springer J. P., Clardy J., Cole R. J., Kirksey J. W., Hill R. K., Carlson M. R., Isidor J. L. Structure and synthesis of moniliformin, a novel cyclobutane microbial toxin. J Am Chem Soc. 1974 Apr 3;96(7):2267–2268. doi: 10.1021/ja00814a055. [DOI] [PubMed] [Google Scholar]
  122. Steinberg G. K., Britt R. H., Enzmann D. R., Finlay J. L., Arvin A. M. Fusarium brain abscess. Case report. J Neurosurg. 1983 Apr;58(4):598–601. doi: 10.3171/jns.1983.58.4.0598. [DOI] [PubMed] [Google Scholar]
  123. Strelow S. A., Kent H. D., Eagle R. C., Jr, Cohen E. J. A case of contact lens related Fusarium solani keratitis. CLAO J. 1992 Apr;18(2):125–127. [PubMed] [Google Scholar]
  124. Sturm A. W., Grave W., Kwee W. S. Disseminated Fusarium oxysporum infection in patient with heatstroke. Lancet. 1989 Apr 29;1(8644):968–968. doi: 10.1016/s0140-6736(89)92560-9. [DOI] [PubMed] [Google Scholar]
  125. Summerbell R. C., Krajden S., Kane J. Potted plants in hospitals as reservoirs of pathogenic fungi. Mycopathologia. 1989 Apr;106(1):13–22. doi: 10.1007/BF00436921. [DOI] [PubMed] [Google Scholar]
  126. Sundaram B. M., Badrinath S., Subramanian S. Studies on mycotic keratitis. Mycoses. 1989 Nov;32(11):568–572. doi: 10.1111/j.1439-0507.1989.tb02183.x. [DOI] [PubMed] [Google Scholar]
  127. Thiel P. G., Marasas W. F., Sydenham E. W., Shephard G. S., Gelderblom W. C., Nieuwenhuis J. J. Survey of fumonisin production by Fusarium species. Appl Environ Microbiol. 1991 Apr;57(4):1089–1093. doi: 10.1128/aem.57.4.1089-1093.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  128. Torres M. A., Mohamed J., Cavazos-Adame H., Martinez L. A. Topical ketoconazole for fungal keratitis. Am J Ophthalmol. 1985 Aug 15;100(2):293–298. doi: 10.1016/0002-9394(85)90795-0. [DOI] [PubMed] [Google Scholar]
  129. Uchiyama N., Shindo Y., Mikoshiba H., Saito H. Cutaneous infection caused by Fusarium solani and Fusarium oxysporum. J Dermatol. 1987 Oct;14(5):471–475. doi: 10.1111/j.1346-8138.1987.tb03610.x. [DOI] [PubMed] [Google Scholar]
  130. Vajpayee R. B., Gupta S. K., Bareja U., Kishore K. Ocular atopy and mycotic keratitis. Ann Ophthalmol. 1990 Oct;22(10):369–372. [PubMed] [Google Scholar]
  131. Valenstein P., Schell W. A. Primary intranasal Fusarium infection. Potential for confusion with rhinocerebral zygomycosis. Arch Pathol Lab Med. 1986 Aug;110(8):751–754. [PubMed] [Google Scholar]
  132. Veglia K. S., Marks V. J. Fusarium as a pathogen. A case report of Fusarium sepsis and review of the literature. J Am Acad Dermatol. 1987 Jan;16(1 Pt 2):260–263. [PubMed] [Google Scholar]
  133. Venditti M., Micozzi A., Gentile G., Polonelli L., Morace G., Bianco P., Avvisati G., Papa G., Martino P. Invasive Fusarium solani infections in patients with acute leukemia. Rev Infect Dis. 1988 May-Jun;10(3):653–660. doi: 10.1093/clinids/10.3.653. [DOI] [PubMed] [Google Scholar]
  134. Venugopal P. L., Venugopal T. L., Gomathi A., Ramakrishna E. S., Ilavarasi S. Mycotic keratitis in Madras. Indian J Pathol Microbiol. 1989 Jul;32(3):190–197. [PubMed] [Google Scholar]
  135. Vidal D., Mavet S. In vitro and in vivo toxicity of T-2 toxin, a Fusarium mycotoxin, to mouse peritoneal macrophages. Infect Immun. 1989 Jul;57(7):2260–2264. doi: 10.1128/iai.57.7.2260-2264.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  136. Viscoli C., Castagnola E., Moroni C., Garaventa A., Manno G., Savioli C. Infection with Fusarium species in two children with neuroblastoma. Eur J Clin Microbiol Infect Dis. 1990 Oct;9(10):773–776. doi: 10.1007/BF02184694. [DOI] [PubMed] [Google Scholar]
  137. Visconti A., Minervini F., Lucivero G., Gambatesa V. Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay. Mycopathologia. 1991 Mar;113(3):181–186. doi: 10.1007/BF00436128. [DOI] [PubMed] [Google Scholar]
  138. Vélez H., Díaz F. Onychomycosis due to saprophytic fungi. Report of 25 cases. Mycopathologia. 1985 Aug;91(2):87–92. doi: 10.1007/BF00436541. [DOI] [PubMed] [Google Scholar]
  139. Wheeler M. S., McGinnis M. R., Schell W. A., Walker D. H. Fusarium infection in burned patients. Am J Clin Pathol. 1981 Mar;75(3):304–311. doi: 10.1093/ajcp/75.3.304. [DOI] [PubMed] [Google Scholar]
  140. Wilhelmus K. R., Robinson N. M., Font R. A., Hamill M. B., Jones D. B. Fungal keratitis in contact lens wearers. Am J Ophthalmol. 1988 Dec 15;106(6):708–714. doi: 10.1016/0002-9394(88)90705-2. [DOI] [PubMed] [Google Scholar]
  141. Williams G., Billson F., Husain R., Howlader S. A., Islam N., McClellan K. Microbiological diagnosis of suppurative keratitis in Bangladesh. Br J Ophthalmol. 1987 Apr;71(4):315–321. doi: 10.1136/bjo.71.4.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  142. Wilson L. A., Ahearn D. G., Jones D. B., Sexton R. R. Fungi from the normal outer eye. Am J Ophthalmol. 1969 Jan;67(1):52–56. doi: 10.1016/0002-9394(69)90007-5. [DOI] [PubMed] [Google Scholar]
  143. Wilson T. M., Nelson P. E., Knepp C. R. Hepatic neoplastic nodules, adenofibrosis, and cholangiocarcinomas in male Fisher 344 rats fed corn naturally contaminated with Fusarium moniliforme. Carcinogenesis. 1985 Aug;6(8):1155–1160. doi: 10.1093/carcin/6.8.1155. [DOI] [PubMed] [Google Scholar]
  144. Wilson T. M., Ross P. F., Owens D. L., Rice L. G., Green S. A., Jenkins S. J., Nelson H. A. Experimental reproduction of ELEM. A study to determine the minimum toxic dose in ponies. Mycopathologia. 1992 Feb;117(1-2):115–120. doi: 10.1007/BF00497287. [DOI] [PubMed] [Google Scholar]
  145. Yamaguchi T., Hubbard A., Fukushima A., Kimura T., Kaufman H. E. Fungus growth on soft contact lenses with different water contents. CLAO J. 1984 Apr-Jun;10(2):166–171. [PubMed] [Google Scholar]
  146. Yang C. S. Research on esophageal cancer in China: a review. Cancer Res. 1980 Aug;40(8 Pt 1):2633–2644. [PubMed] [Google Scholar]
  147. Yarom R., More R., Eldor A., Yagen B. The effect of T-2 toxin on human platelets. Toxicol Appl Pharmacol. 1984 Apr;73(2):210–217. doi: 10.1016/0041-008x(84)90326-0. [DOI] [PubMed] [Google Scholar]
  148. Yarom R., More R., Sherman Y., Yagen B. T-2 toxin-induced pathology in the hearts of rats. Br J Exp Pathol. 1983 Oct;64(5):570–577. [PMC free article] [PubMed] [Google Scholar]
  149. Yarom R., Sherman Y., More R., Ginsburg I., Borinski R., Yagen B. T-2 toxin effect on bacterial infection and leukocyte functions. Toxicol Appl Pharmacol. 1984 Aug;75(1):60–68. doi: 10.1016/0041-008x(84)90076-0. [DOI] [PubMed] [Google Scholar]
  150. Yoo H. S., Norred W. P., Wang E., Merrill A. H., Jr, Riley R. T. Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. Toxicol Appl Pharmacol. 1992 May;114(1):9–15. doi: 10.1016/0041-008x(92)90090-f. [DOI] [PubMed] [Google Scholar]
  151. Young C. N., Meyers A. M. Opportunistic fungal infection by Fusarium oxysporum in a renal transplant patient. Sabouraudia. 1979 Sep;17(3):219–223. [PubMed] [Google Scholar]
  152. Young J. B., Ahmed-Jushuf I. H., Brownjohn A. M., Parsons F. M., Foulkes S. J., Evans E. G. Opportunistic peritonitis in continuous ambulatory peritoneal dialysis. Clin Nephrol. 1984 Nov;22(5):268–269. [PubMed] [Google Scholar]
  153. Young N. A., Kwon-Chung K. J., Kubota T. T., Jennings A. E., Fisher R. I. Disseminated infection by Fusarium moniliforme during treatment for malignant lymphoma. J Clin Microbiol. 1978 Jun;7(6):589–594. doi: 10.1128/jcm.7.6.589-594.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  154. Zach T. L., Penn R. G., Gnarra D. J., Bever J. L. Fusarium moniliforme pneumonia. Nebr Med J. 1987 Jan;72(1):6–9. [PubMed] [Google Scholar]
  155. el-Ani A. S. Disseminated infection caused by Fusarium solani in a patient with aplastic anemia. N Y State J Med. 1990 Dec;90(12):609–610. [PubMed] [Google Scholar]

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