Table II.
Case–control analysis of five loci from Chinese GWAS in South African Black and Mixed Ancestry OSCC
| Black population | Mixed Ancestry population | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR (95% CI) | P value | Cases | Controls | OR (95% CI) | P value | |||
| PLCE1 rs2274223 | His/His | 140 (33.5%) | 302 (35.5%) | His/His | 78 (30.7%) | 310 (36.2%) | ||||
| His/Arg | 208 (49.8%) | 411 (48.4%) | His/Arg | 130 (51.2%) | 408 (47.6%) | |||||
| Arg/Arg | 70 (16.7%) | 137 (16.1%) | Arg/Arg | 46 (18.1%) | 139 (16.2%) | |||||
| His | 488 (58.4%) | 1015 (59.7%) | Reference | — | His | 286 (56.3%) | 1028 (60.0%) | Reference | — | |
| Arg | 348 (41.6%) | 685 (40.3%) | 1.06 (0.89–1.25) | 0.5208 | Arg | 222 (43.7%) | 686 (40.0%) | 1.16 (0.95–1.42) | 0.1386 | |
| C20orf54 rs13042395 | C/C | 402 (99.5%) | 837 (98.9%) | C / C | 221 (87.0%) | 742 (87.2%) | ||||
| C/T | 2 (0.5%) | 9 (1.1%) | C / T | 32 (12.6%) | 103 (12.1%) | |||||
| T/T | 0 (0.0%) | 0 (0.0%) | T / T | 1 (0.4%) | 6 (0.7%) | |||||
| C | 806 (99.8%) | 1683 (99.5%) | Reference | — | C | 474 (93.3%) | 1587 (93.2%) | Reference | — | |
| T | 2 (0.2%) | 9 (0.5%) | 0.46 (0.10–2.15) | 0.3150 | T | 34 (6.7%) | 115 (6.8%) | 0.99 (0.67–1.47) | 1.0000 | |
| near UNC5CL rs10484761 | G/G | 107 (26.9%) | 225 (26.6%) | A / A | 105 (41.5%) | 398 (47.2%) | ||||
| G/A | 210 (52.8%) | 435 (51.4%) | G / A | 117 (46.2%) | 362 (42.9%) | |||||
| A/A | 81 (20.4%) | 186 (22.0%) | G / G | 31 (12.3%) | 84 (10.0%) | |||||
| G | 424 (53.3%) | 885 (52.3%) | Reference | — | A | 327 (64.6%) | 1158 (68.6%) | Reference | — | |
| A | 372 (46.7%) | 807 (47.7%) | 0.96 (0.81–1.14) | 0.6542 | G | 179 (35.4%) | 530 (31.4%) | 1.20 (0.97–1.47) | 0.0933 | |
| PDE4D rs10052657 | C/C | 300 (74.6%) | 642 (76.0%) | C / C | 171 (67.1%) | 613 (71.6%) | ||||
| C/A | 94 (23.4%) | 190 (22.5%) | C / A | 79 (31.0%) | 220 (25.7%) | |||||
| A/A | 8 (2.0%) | 13 (1.5%) | A / A | 5 (2.0%) | 23 (2.7%) | |||||
| C | 694 (86.3%) | 1474 (87.2%) | Reference | — | C | 421 (82.5%) | 1446 (84.5%) | Reference | — | |
| A | 110 (13.7%) | 216 (12.8%) | 1.08 (0.85–1.38) | 0.5329 | A | 89 (17.5%) | 266 (15.5%) | 1.15 (0.88–1.50) | 0.3005 | |
| RUNX1 rs2014300 | A/A | 152 (37.7%) | 311 (37.1%) | G / G | 81 (32.1%) | 346 (40.9%) | ||||
| A/G | 197 (48.9%) | 378 (45.1%) | A / G | 121 (48.0%) | 374 (44.2%) | |||||
| G/G | 54 (13.4%) | 149 (17.8%) | A / A | 50 (19.8%) | 126 (14.9%) | |||||
| A | 501 (62.2%) | 1000 (59.7%) | Reference | — | G | 283 (56.2%) | 1066 (63.0%) | Reference | — | |
| G | 305 (37.8%) | 676 (40.3%) | 0.90 (0.76–1.07) | 0.2342 | A | 221 (43.8%) | 626 (37.0%) | 1.33 (1.09–1.63) | 0.0055 | |