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. 1994 Apr;14(4):2235–2242. doi: 10.1128/mcb.14.4.2235

Multiple cis-acting targeting sequences are required for orb mRNA localization during Drosophila oogenesis.

V Lantz 1, P Schedl 1
PMCID: PMC358590  PMID: 8139529

Abstract

The targeting of positional information to specific regions of the oocyte or early embryo is one of the key processes in establishing anterior-posterior and dorsal-ventral polarity. In many developmental systems, this is accomplished by localization of mRNAs. The germ line-specific Drosophila orb gene plays a critical role in defining both axes of the developing oocyte, and its mRNA is localized in a complex pattern during oogenesis. We have identified a 280-bp sequence from the orb 3' untranslated region capable of reproducing this complex localization pattern. Furthermore, we have found that multiple cis-acting elements appear to be required for proper targeting of orb mRNA.

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Selected References

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