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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 15;64:348–356. doi: 10.1016/j.neuropharm.2012.07.016

Fig. 3.

Fig. 3

Effects of nicotine on PPI in WT and DAT KO mice. PPI in WT and DAT KO mice after administration of saline (sal), 0.3 mg/kg nicotine (Nic 0.3 mg), 1 mg/kg nicotine (Nic 1 mg), or 3 mg/kg nicotine (Nic 3 mg); DAT KO mice treated with saline displayed significantly reduced PPI compared with WT mice. Nicotine (1 mg/kg) significantly ameriolated PPI deficits in DAT KO mice, which was significant for the pp12 dB condition. %PPI values represent mean ± SEM. *p < 0.05, compared with WT Nic 0.3 mg pp3 dB; ***p < 0.001 compared with WT sal; #p < 0.005 compared with DAT KO sal pp12 dB. N = 8–16 per treatment condition per genotype (male N = 4–7, female N = 4–9).