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. Author manuscript; available in PMC: 2014 Feb 19.
Published in final edited form as: Biochemistry. 2013 Feb 6;52(7):1249–1259. doi: 10.1021/bi301500d

Figure 1.

Figure 1

The human β-cardiac myosin S1 motor binds the actin filament and generates tension with the lever-arm swing. In a muscle fiber the lever-arm links to the myosin filament where Load and Tension vectors are shown. The regulatory light chain (HCRLC in bold red) indicates positions 20, 134, and 162 with mutations implicated in HCM. The PAGFP is linked to the light chain (dashed yellow linker near G162) and reports lever-arm orientation. The ELC is shown in cyan. In the motor, black regions are the actin binding site, the blue α-helix is the switch 2 helix and the green β-sheet is the active site with entrance at Loop 1.