Table 1.
Measured Parameters of Rods with Perturbations in R* Phosphorylation
| GCAPs+/+ Background (Feedback)
|
GCAPs−/− Background (No Feedback)
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Dark Current (rmax) (pA) | Single-Photon Response Amplitude (pA) | Dim Flash Time to Peak (ms) | Dominant Time Constant of Recovery τD (ms) | ΔTsat (ms) | Dark Current (rmax) (pA) | Single-Photon Response Amplitude (pA) | Dim Flash Time to Peak (ms) | Dominant Time Constant of Recovery τD (ms) | ΔTsat (ms) |
| WT | 13.3 ± 0.7 (19) | 0.61 ± 0.06 (19) | 130 ± 10 (19) | 204 ± 17 (8) | — | 16.7 ± 0.9 (17) | 2.3 ± 0.2 (17) | 300 ± 20 (17) | 200 ± 15 (14) | — |
|
| ||||||||||
| Grk1+/− | 11.7 ± 0.7 (25) | 0.65 ± .06 (25) | 130 ± 10 (25) | 212 ± 10 (22) | +180 | 17.6 ± 1.5 (17) | 3.4 ± 0.4 (17) | 450 ± 30 (14) | 208 ± 17 (17) | +180 |
|
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| Grk1S561L | 13.6 ± 0.6 (19) | 0.47 ± 0.07 (11) | 110 ± 10 (11) | 190 ± 14 (12) | −250 | 15.3 ± 1.0 (20) | 0.96 ± 0.13 (18) | 240 ± 10 (20) | 182 ± 13 (16) | −220 |