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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Atherosclerosis. 2012 Feb 2;222(1):138–147. doi: 10.1016/j.atherosclerosis.2012.01.039

Table 2A.

Candidate gene SNP associations for ankle-brachial index: discovery meta-analysis, p < 10−4. European and European Americans, n = 21,547.

SNP Chr Physical position Nearest gene Feature Major/minor
allele		 MAFa Beta 95% CI p Value phetb
rs2171209 6 159,103,550 SYTL3 Intron C/T 0.22 −0.007 −0.010,−0.004 6.02×10−7 0.55
rs290481 10 114,913,815 TCF7L2 Intron C/T 0.17 −0.008 −0.011,−0.005 7.01×10−7 0.08
rs11061318 12 130,135,058 GPR133 Missense Ser → Leu C/T 0.03 −0.016− −0.023,−0.009 4.46×10−6 0.91
a

MAF = minor allele frequency.

b

p-for-heterogeneity by Cochran’s Q.