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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Atherosclerosis. 2012 Feb 2;222(1):138–147. doi: 10.1016/j.atherosclerosis.2012.01.039

Table 2B.

Candidate gene SNP associations for PAD (ABI < 0.9): discovery meta-analysis, p < 10−4. European and European Americans, n = 20,539.

SNP Chr Physical position Nearest gene Feature Major/minor
allele		 MAFa Odds ratio 95% CI p Value phetb
rs11088283 21 34,745,649 KCNE1 Intron A/G 0.47 0.85 (0.78, 0.93) 4.88×10−5 0.09
rs3745274 19 46,204,681 CYP2B6 Coding, non-synonymous G/T 0.24 1.24 (1.12, 1.38) 4.99×10−5 0.01
rs12428227 13 109,700,293 COL4A1 Intron A/G 0.17 1.23 (1.10, 1.38) 5.20×10−5 0.14
rs17151901 8 10,290,865 MSRA Intron C/T 0.02 1.36 (1.09, 1.69) 6.53×10−5 0.01
a

MAF = minor allele frequency.

b

p-for-heterogeneity by Cochran’s Q.