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. 1991 Jan;11(1):582–585. doi: 10.1128/mcb.11.1.582

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

D Ginsberg 1, D Michael-Michalovitz 1, D Ginsberg 1, M Oren 1
PMCID: PMC359675  PMID: 1986251

Abstract

A temperature-sensitive mutant of p53, p53Val-135, was found to be able to arrest cell proliferation when overexpressed at 32.5 degrees C. While much of the protein was cytoplasmic in cells proliferating at 37.5 degrees C, it became predominantly nuclear at 32.5 degrees C. Concomitantly, p53Val-135 became destabilized, although not to the extent seen in primary fibroblasts.

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Selected References

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