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. 1991 Feb;11(2):1156–1160. doi: 10.1128/mcb.11.2.1156

B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits.

C Murre 1, A Voronova 1, D Baltimore 1
PMCID: PMC359799  PMID: 1990271

Abstract

Recent studies have identified a family of DNA-binding proteins that share a common DNA-binding and dimerization domain with the potential to form a helix-loop-helix (HLH) structure. Various HLH proteins can form heterodimers that bind to a common DNA sequence, termed the E2-box. We demonstrate here that E2-box-binding B-cell- and myocyte-specific nuclear factors contain subunits which are identical or closely related to ubiquitously expressed (E12/E47) HLH proteins. These biochemical function for E12/E47-like molecules in mammalian differentiation, similar to the genetically defined function of daughterless in Drosophila development.

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Selected References

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