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. 1991 Feb;11(2):1167–1170. doi: 10.1128/mcb.11.2.1167

Transformation-defective v-ski induces MyoD and myogenin expression but not myotube formation.

C Colmenares 1, J K Teumer 1, E Stavnezer 1
PMCID: PMC359802  PMID: 1846665

Abstract

The ski oncogene induces muscle differentiation in otherwise nonmyogenic quail embryo cells (C. Colmenares and E. Stavnezer, Cell 59:293-303, 1989). Here we report that v-ski induces both MyoD and myogenin expression, suggesting that activation of these muscle regulatory genes may be a critical step in ski-induced myogenesis. We also describe a transformation-defective mutant of v-ski (tdM5i) that fails to induce myotube formation, although it induces the expression of many muscle-specific genes, including the MyoD and myogenin genes. Therefore, if activation of MyoD and myogenin expression is a necessary component of the myogenic program triggered by ski, it is clearly insufficient to account for complete muscle differentiation.

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Selected References

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