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. 1991 Feb;11(2):1171–1175. doi: 10.1128/mcb.11.2.1171

An okadaic acid-sensitive phosphatase negatively controls the cyclin degradation pathway in amphibian eggs.

T Lorca 1, D Fesquet 1, F Zindy 1, F Le Bouffant 1, M Cerruti 1, C Brechot 1, G Devauchelle 1, M Dorée 1
PMCID: PMC359804  PMID: 1846666

Abstract

Inhibition of okadaic acid-sensitive phosphatases released the cyclin degradation pathway from its inhibited state in extracts prepared from unfertilized Xenopus eggs arrested at the second meiotic metaphase. It also switched on cyclin protease activity in a permanent fashion in interphase extracts prepared from activated eggs. Even after cdc2 kinase inactivation, microinjection of okadaic acid-treated interphase extracts pushed G2-arrested recipient oocytes into the M phase, suggesting that the phosphatase inhibitor stabilizes the activity of an unidentified factor which shares in common with cdc2 kinase the maturation-promoting factor activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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