Table 1.
Cellular transcription factors predicted to bind to their respective putative consensus sequences on the ERVK LTR
| Transcription Factor | Consensus sequence | References |
|---|---|---|
| Activating Protein 1 (AP-1); c-Jun/c-Fos |
TGA(G/C)TCA |
[34] |
| Activating Protein 2 (AP-2α) |
GCCNNNGGC |
[35] |
| Androgen receptor (AR) |
GG(A/T)ACANNNTGTTCT (ARE) |
[36] |
| cAMP Response Element Binding (CREB) protein |
T(G/T)ACGTCA (CRE) |
[37] |
| cAMP Response Element Modulator (CREM-α) |
T(G/T)ACGTCA (CRE) |
[37] |
| CCAAT-Enhancer Binding Protein (C/EBP) |
N(A/G)CCAAT |
[38,39] |
| Cellular Myeloblastosis virus protein (c-Myb) |
(T/C)AAC(G/T)G |
[40] |
| Cellular Myelocytomatosis virus protein (c-Myc) |
NNNCACGTGNN (E-box) |
[41,42] |
| Early B-cell Factor (EBF) |
CCCNNGGG |
[43] |
| Estrogen Receptor (ER-α; ER-β) |
GGTCANNNTGACC (ERE) |
[44] |
| E-twenty six (ETS-1; ETS-2) |
GGA(A/T) |
[45] |
| ETS-like Transcription Factor 1 (Elk-1) |
GGA(A/T) |
[45] |
| GATA binding protein (GATA) |
(A/T)GATA(A/G) |
[46] |
| Glucocorticoid Receptor (GR-α; GR-β) |
GGTACANNNTGTTC (GRE) |
[47] |
| Ikarose-1 (Ik-1) |
TGGGA(A/T) |
[48] |
| Interferon Regulatory Factor (IRF-1; IRF-3; IRF-7) |
GAAANN repeats (ISRE) |
[49,50] |
| Lymphoid Enhancer-binding Factor 1 (LEF-1) |
CTTTGAA |
[51] |
| Microphthalmia-associated Transcription Factor-M (MITF-M) |
CA(C/T)GTG (E-box) |
[23] |
| Monocyte Enhancer Factor-2 (MEF-2A) |
CT(A/T)(A/T)AAATAG |
[52] |
| Myc Associated Zinc finger protein (MAZ) |
GGGAGGG |
[53] |
| Nuclear Factor of Activated T cells (NFAT-1) |
GGAGAA |
[54] |
| Nuclear Factor I (NF-I) |
TTGGCNNNNNGCCAA |
[55] |
| Nuclear Factor Kappa B (NF-kB) |
GG(G/A)(G/A)NN(C/T)(C/T)CC |
[56] |
| Octamer-1 (OCT-1) |
ATGCAAAT (ORE) |
[57] |
| Polyomavirus Enhancer Activator 3 (PEA-3) |
GGA(A/T) |
[45] |
| Progesterone Receptor (PR-A; PR-B) |
GNACANNNTGTNC (PRE) |
[58] |
| Protein 53 (p53) |
CATTAG |
[59] |
| Recombination signal Binding Protein-Jk (RBP-Jk) |
(C/T)GTGGGAA |
[60] |
| Sex-determining Region Y (SRY) |
(A/T)(A/T)CAA(A/T) |
[61] |
| Signal Transducers and Activators of Transcription (STAT) |
TTCNNNNGAA |
[62] |
| Specificity Protein (Sp-1; Sp-3) |
GGGCGG (GC-box) |
[22] |
| TATA Binding Protein (TBP) |
TATAAA (TATA box) |
[63] |
| T cell Factor 1 (TCF-1) |
(G/C)ATCAAAGG |
[64] |
| Transcription Factor II D (TFII-D) |
TATAAA (TATA box) |
[63] |
| Transcription Factor II I (TFII-I) |
CANNTG |
[65] |
| Upstream Transcription Factor 1 (USF-1) |
CACGTG (E-box) |
[41] |
| Vitamin D Receptor (VDR) |
G(G/T)TCA |
[66] |
| X-box binding protein (XBP-1) |
CCACG |
[67] |
| Yin Yang 1 (YY1) | GCCATNTT | [68] |