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. 1991 Apr;11(4):2291–2295. doi: 10.1128/mcb.11.4.2291

Transcriptional suppression of cellular gene expression by c-Myc.

B S Yang 1, T J Geddes 1, R J Pogulis 1, B de Crombrugghe 1, S O Freytag 1
PMCID: PMC359932  PMID: 2005911

Abstract

High levels of c-Myc in mouse 3T3-L1 cells specifically suppress the expression of three collagen genes. This effect is exerted through collagen promoter sequences and requires the leucine zipper motif of c-Myc. Our data suggest that an important aspect of c-Myc transforming activity is the ability to suppress specific cellular gene transcription.

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Selected References

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