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. 1991 Apr;11(4):2319–2323. doi: 10.1128/mcb.11.4.2319

Identification of a fibroblast growth factor-binding protein in Drosophila melanogaster.

J S Doctor 1, F M Hoffmann 1, B B Olwin 1
PMCID: PMC359941  PMID: 1848676

Abstract

As assessed by competitive binding and protein-crosslinking experiments, Drosophila melanogaster cells possess basic fibroblast growth factor (bFGF)-specific binding proteins that are similar to FGF receptors on vertebrate cells in molecular weight and binding affinity; these D. melanogaster cells, however, have no detectable binding proteins for acidic fibroblast growth factor (aFGF). Consistent with the presence of bFGF-specific binding proteins, D. melanogaster cells degrade bFGF but not aFGF. These results indicate the conservation of heparin-binding growth factors and receptors between vertebrates and D. melanogaster.

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Selected References

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