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. 1991 May;11(5):2901–2904. doi: 10.1128/mcb.11.5.2901

Modulation of c-kit mRNA and protein by hemopoietic growth factors.

M J Welham 1, J W Schrader 1
PMCID: PMC360082  PMID: 1708097

Abstract

We examined the effects of various hemopoietins on c-kit mRNA and protein expression. Interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and erythropoietin, but not IL-4, down-regulated levels of c-kit mRNA expressed by mast cells and stem cell progenitors. The effect of IL-3 was dominant and independent of cell growth or viability and was paralleled by reduced expression in c-kit protein. These observations indicate that regulation of c-kit expression is closely interlinked with the molecular mechanisms triggered by erythropoietin, IL-3, and granulocyte-macrophage colony-stimulating factor.

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