Figure 1. Neuropilin 1 expression by regulatory T cells is required for tumor infiltration. (A) Tumor-produced vascular endothelial growth factor (VEGF) attracts NRP1-expressing regulatory T cells (Tregs), resulting in local immunosuppression accompanied by tumor progression. (B) The T cell-specific ablation of NRP1 expression blocks tumor infiltration by Tregs, enabling the development of effective antitumor immune responses.