Abstract
Ring-infected erythrocyte surface antigen-negative isolates of Plasmodium falciparum demonstrate a complex DNA rearrangement with inversion of 5' coding sequences, deletion of upstream and flanking sequences, and healing of the truncated chromosome by telomere addition. An inversion intermediate that results in the telomeric gene structure for RESA has been identified in the pathway. This inversion creates a mitotically stable substrate for the sequence-specific addition of telomere repeats at the deletion breakpoint.
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Selected References
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- Anders R. F., Brown G. V., Edwards A. Characterization of an S antigen synthesized by several isolates of Plasmodium falciparum. Proc Natl Acad Sci U S A. 1983 Nov;80(21):6652–6656. doi: 10.1073/pnas.80.21.6652. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown G. V., Culvenor J. G., Crewther P. E., Bianco A. E., Coppel R. L., Saint R. B., Stahl H. D., Kemp D. J., Anders R. F. Localization of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum in merozoites and ring-infected erythrocytes. J Exp Med. 1985 Aug 1;162(2):774–779. doi: 10.1084/jem.162.2.774. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cappai R., van Schravendijk M. R., Anders R. F., Peterson M. G., Thomas L. M., Cowman A. F., Kemp D. J. Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion. Mol Cell Biol. 1989 Aug;9(8):3584–3587. doi: 10.1128/mcb.9.8.3584. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Corcoran L. M., Forsyth K. P., Bianco A. E., Brown G. V., Kemp D. J. Chromosome size polymorphisms in Plasmodium falciparum can involve deletions and are frequent in natural parasite populations. Cell. 1986 Jan 17;44(1):87–95. doi: 10.1016/0092-8674(86)90487-3. [DOI] [PubMed] [Google Scholar]
- Favaloro J. M., Coppel R. L., Corcoran L. M., Foote S. J., Brown G. V., Anders R. F., Kemp D. J. Structure of the RESA gene of Plasmodium falciparum. Nucleic Acids Res. 1986 Nov 11;14(21):8265–8277. doi: 10.1093/nar/14.21.8265. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Giphart-Gassler M., Plasterk R. H., van de Putte P. G inversion in bacteriophage Mu: a novel way of gene splicing. Nature. 1982 May 27;297(5864):339–342. doi: 10.1038/297339a0. [DOI] [PubMed] [Google Scholar]
- Jensen J. B., Trager W. Plasmodium falciparum in culture: establishment of additional strains. Am J Trop Med Hyg. 1978 Jul;27(4):743–746. doi: 10.4269/ajtmh.1978.27.743. [DOI] [PubMed] [Google Scholar]
- Kemp D. J., Coppel R. L., Cowman A. F., Saint R. B., Brown G. V., Anders R. F. Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: detection with antibodies from immune humans. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3787–3791. doi: 10.1073/pnas.80.12.3787. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kemp D. J., Thompson J. K., Walliker D., Corcoran L. M. Molecular karyotype of Plasmodium falciparum: conserved linkage groups and expendable histidine-rich protein genes. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7672–7676. doi: 10.1073/pnas.84.21.7672. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pologe L. G., Ravetch J. V. A chromosomal rearrangement in a P. falciparum histidine-rich protein gene is associated with the knobless phenotype. 1986 Jul 31-Aug 6Nature. 322(6078):474–477. doi: 10.1038/322474a0. [DOI] [PubMed] [Google Scholar]
- Pologe L. G., Ravetch J. V. Large deletions result from breakage and healing of P. falciparum chromosomes. Cell. 1988 Dec 2;55(5):869–874. doi: 10.1016/0092-8674(88)90142-0. [DOI] [PubMed] [Google Scholar]
- Trager W., Tershakovec M., Lyandvert L., Stanley H., Lanners N., Gubert E. Clones of the malaria parasite Plasmodium falciparum obtained by microscopic selection: their characterization with regard to knobs, chloroquine sensitivity, and formation of gametocytes. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6527–6530. doi: 10.1073/pnas.78.10.6527. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Uni S., Masuda A., Stewart M. J., Igarashi I., Nussenzweig R., Aikawa M. Ultrastructural localization of the 150/130 Kd antigens in sexual and asexual blood stages of Plasmodium falciparum-infected human erythrocytes. Am J Trop Med Hyg. 1987 May;36(3):481–488. doi: 10.4269/ajtmh.1987.36.481. [DOI] [PubMed] [Google Scholar]
- Van der Ploeg L. H., Smits M., Ponnudurai T., Vermeulen A., Meuwissen J. H., Langsley G. Chromosome-sized DNA molecules of Plasmodium falciparum. Science. 1985 Aug 16;229(4714):658–661. doi: 10.1126/science.3895435. [DOI] [PubMed] [Google Scholar]
- Zeff R. A., Gopas J., Steinhauer E., Rajan T. V., Nathenson S. G. Analysis of somatic cell H-2 variants to define the structural requirements for class I antigen expression. J Immunol. 1986 Aug 1;137(3):897–903. [PubMed] [Google Scholar]
- Zieg J., Simon M. Analysis of the nucleotide sequence of an invertible controlling element. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4196–4200. doi: 10.1073/pnas.77.7.4196. [DOI] [PMC free article] [PubMed] [Google Scholar]