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. 1990 Jun;10(6):3258–3261. doi: 10.1128/mcb.10.6.3258

Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein.

C L Dent 1, J K Estridge 1, L M Kemp 1, D S Latchman 1
PMCID: PMC360694  PMID: 2160597

Abstract

The herpes simplex virus virion protein Vmw65 trans activates the viral immediate-early genes and some octamer-containing cellular genes, including that encoding histone H2B. We found, however, that a truncated form of this virion protein repressed H2B gene transcription and also dominantly inhibited induction of the gene by intact Vmw65. A cell line expressing this truncated protein expressed reduced levels of H2B and grew more slowly than the parental cell line or a similar line expressing the intact protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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